KEGG   MODULE: M00567
Entry
M00567            Pathway   Module                                 
Name
Methanogenesis, CO2 => methane
Definition
(K00200+K00201+K00202+K00203-K11261+(K00205,K11260,K00204)) K00672 K01499 (K00319,K13942) K00320 (K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584) (K00399+K00401+K00402) (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
Diagram
M00567

Orthology
K00200+K00201+K00202+K00203+K11261 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015]  
 
K00205,K11260,K00204  
4Fe-4S ferredoxin
K00672  
formylmethanofuran--tetrahydromethanopterin N-formyltransferase [EC:2.3.1.101] [RN:R03390]
K01499  
methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27] [RN:R03464]
K00319  
methylenetetrahydromethanopterin dehydrogenase [EC:1.5.99.9] [RN:R04456]
K13942  
5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2] [RN:R04455]
K00320  
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase [EC:1.5.99.11] [RN:R04464]
K00577+K00578+K00579+K00580+K00581+K00582+K00583+K00584  
tetrahydromethanopterin S-methyltransferase [EC:7.2.1.4] [RN:R04347]
K00399+K00401+K00402  
methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
K22480+K22481+K22482  
heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
K03388+K03389+K03390  
heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
K08264+K08265  
heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
K14126+K14128  
F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
K14127  
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
K22516+K00125  
formate dehydrogenase (coenzyme F420) [EC1.8.98.6] [RN:R11944]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00680  Methane metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R03015  
R03390  
R03464  
R04456,R04455  
R04464  
R04347  
R04541  
R11931,R04540,R11928,R11943,R11944  
Compound
C00011  CO2
C01001  Formylmethanofuran
C01274  5-Formyl-5,6,7,8-tetrahydromethanopterin
C04330  5,10-Methenyltetrahydromethanopterin
C04377  5,10-Methylenetetrahydromethanopterin
C04488  5-Methyl-5,6,7,8-tetrahydromethanopterin
C03576  Coenzyme M
C03920  2-(Methylthio)ethanesulfonate
C04628  Coenzyme B
C01438  Methane
C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
Comment
Organism group: methanogenic archaea
Reference
PMID:18378594
  Authors
Liu Y, Whitman WB
  Title
Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea.
  Journal
Ann N Y Acad Sci 1125:171-89 (2008)
DOI:10.1196/annals.1419.019
Reference
PMID:18587410
  Authors
Thauer RK, Kaster AK, Seedorf H, Buckel W, Hedderich R
  Title
Methanogenic archaea: ecologically relevant differences in energy conservation.
  Journal
Nat Rev Microbiol 6:579-91 (2008)
DOI:10.1038/nrmicro1931
Reference
PMID:14657125
  Authors
L'Haridon S, Reysenbach AL, Banta A, Messner P, Schumann P, Stackebrandt E, Jeanthon C
  Title
Methanocaldococcus indicus sp. nov., a novel hyperthermophilic methanogen isolated from the Central Indian Ridge.
  Journal
Int J Syst Evol Microbiol 53:1931-5 (2003)
DOI:10.1099/ijs.0.02700-0
LinkDB

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