KEGG   PATHWAY: mgl04082
Entry
mgl04082                    Pathway                                
Name
Neuroactive ligand signaling - Malassezia globosa
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mgl04082  Neuroactive ligand signaling
mgl04082

Organism
Malassezia globosa [GN:mgl]
Gene
MGL_0613  [KO:K04630]
MGL_1772  [KO:K04536]
MGL_2756  [KO:K02677] [EC:2.7.11.13]
MGL_3248  [KO:K04345] [EC:2.7.11.11]
MGL_3604  [KO:K15015]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00029  UDP-glucose
C00037  Glycine
C00075  UTP
C00076  Calcium cation
C00114  Choline
C00165  Diacylglycerol
C00212  Adenosine
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01330  Sodium cation
C01996  Acetylcholine
C02210  beta-Endorphin
C02758  alpha-Melanotropin
C03758  Dopamine
C11684  MET-enkephalin
C15871  Nocistatin
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C16041  Leu-enkephalin
C16044  Nociceptin
C16094  Substance P
C16095  Neuropeptide K
C16096  Neuropeptide gamma
C16097  Neurokinin A
C16098  Neurokinin B
C16099  Endokinin A/B
C16100  Endokinin C
C16101  Endokinin D
C16103  Agouti related protein (87-132)
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
PMID:37385351
  Authors
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
  Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
  Journal
Ageing Res Rev 89:101994 (2023)
DOI:10.1016/j.arr.2023.101994
Reference
PMID:31726793
  Authors
Malik AR, Willnow TE
  Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
  Journal
Int J Mol Sci 20:ijms20225671 (2019)
DOI:10.3390/ijms20225671
Reference
PMID:25116141
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:35055019
  Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
  Journal
Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
PMID:33924731
  Authors
Wang Y, Tan B, Wang Y, Chen Z
  Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
  Journal
Molecules 26:molecules26082258 (2021)
DOI:10.3390/molecules26082258
Reference
PMID:36757901
  Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
  Title
Dopamine, Immunity, and Disease.
  Journal
Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
PMID:25037203
  Authors
Savica R, Benarroch EE
  Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
  Journal
Neurology 83:758-67 (2014)
DOI:10.1212/WNL.0000000000000719
Reference
PMID:33651238
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
  Journal
Cell Mol Neurobiol 42:1671-1692 (2022)
DOI:10.1007/s10571-021-01064-9
Reference
PMID:35492402
  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
  Journal
Curr Res Immunol 2:202-217 (2021)
DOI:10.1016/j.crimmu.2021.11.001
Reference
PMID:39337347
  Authors
Szukiewicz D
  Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
  Journal
Int J Mol Sci 25:ijms25189859 (2024)
DOI:10.3390/ijms25189859
Reference
PMID:33907179
  Authors
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
  Title
From purines to purinergic signalling: molecular functions and human diseases.
  Journal
Signal Transduct Target Ther 6:162 (2021)
DOI:10.1038/s41392-021-00553-z
Reference
PMID:16715052
  Authors
Fields RD, Burnstock G
  Title
Purinergic signalling in neuron-glia interactions.
  Journal
Nat Rev Neurosci 7:423-36 (2006)
DOI:10.1038/nrn1928
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:28360832
  Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
  Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
  Journal
Front Neurosci 11:128 (2017)
DOI:10.3389/fnins.2017.00128
Reference
PMID:26956246
  Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
  Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
  Journal
Pharmacol Rev 68:419-57 (2016)
DOI:10.1124/pr.114.009209
Reference
PMID:36589829
  Authors
Campo A, Dufour S, Rousseau K
  Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
  Journal
Front Endocrinol (Lausanne) 13:1056939 (2022)
DOI:10.3389/fendo.2022.1056939
KO pathway
ko04082   

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