KEGG PATHWAY: mmu03060

KEGG

PATHWAY: mmu03060

Entry

mmu03060                    Pathway

Name

Protein export - Mus musculus (house mouse)

Description

The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

Protein export

Other DBs

GO:	0043952 0043953

Organism

Mus musculus (house mouse) [GN:mmu]

Gene

Oxa1l; oxidase assembly 1-like [KO:K03217]

Srp54a; signal recognition particle 54A [KO:K03106] [EC:3.6.5.4]

Srp54b; signal recognition particle 54B [KO:K03106] [EC:3.6.5.4]

Srp54c; signal recognition particle 54C [KO:K03106] [EC:3.6.5.4]

Sec61a1; SEC61 translocon subunit alpha 1 [KO:K10956]

Sec61a2; SEC61 translocon subunit alpha 2 [KO:K10956]

Sec61b; SEC61 translocon subunit beta [KO:K09481]

Sec61bl; SEC61 translocon subunit beta like [KO:K09481]

Gm33666; predicted gene, 33666 [KO:K09481]

Sec61g; SEC61 translocon subunit gamma [KO:K07342]

Gm15266; predicted gene 15266 [KO:K07342]

Gm30534; predicted gene, 30534 [KO:K07342]

Gm10144; predicted pseudogene 10144 [KO:K07342]

Gm16261; predicted gene 16261 [KO:K07342]

Sec62; SEC62 homolog, preprotein translocation [KO:K12275]

Sec63; SEC63 homolog, protein translocation regulator [KO:K09540]

Hspa5; heat shock protein 5 [KO:K09490] [EC:3.6.4.10]

Srp9; signal recognition particle 9 [KO:K03109]

Srp14; signal recognition particle 14 [KO:K03104]

Srp72; signal recognition particle 72 [KO:K03108]

Srp68; signal recognition particle 68 [KO:K03107]

Srp19; signal recognition particle 19 [KO:K03105]

Srpra; signal recognition particle receptor alpha [KO:K13431]

Srprb; signal recognition particle receptor, B subunit [KO:K12272]

Get3; guided entry of tail-anchored proteins factor 3, ATPase [KO:K01551] [EC:7.3.2.7 7.3.-.-]

Get4; golgi to ER traffic protein 4 [KO:K23387]

Gm44504; predicted readthrough transcript (NMD candidate), 44504 [KO:K23388]

Ubl4b; ubiquitin-like 4B [KO:K23388]

Ubl4a; ubiquitin-like 4A [KO:K23388]

Bag6; BCL2-associated athanogene 6 [KO:K23390]

Sgta; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [KO:K16365]

Get1; guided entry of tail-anchored proteins factor 1 [KO:K22384]

Tmem208; transmembrane protein 208 [KO:K27164]

Spcs1; signal peptidase complex subunit 1 homolog (S. cerevisiae) [KO:K12946] [EC:3.4.-.-]

Spcs2; signal peptidase complex subunit 2 homolog (S. cerevisiae) [KO:K12947] [EC:3.4.-.-]

Spcs3; signal peptidase complex subunit 3 homolog (S. cerevisiae) [KO:K12948] [EC:3.4.-.-]

Arxes1; adipocyte-related X-chromosome expressed sequence 1 [KO:K12948] [EC:3.4.-.-]

Arxes2; adipocyte-related X-chromosome expressed sequence 2 [KO:K12948] [EC:3.4.-.-]

Sec11c; SEC11 homolog C, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]

Sec11a; SEC11 homolog A, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]

Immp1l; IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) [KO:K09647] [EC:3.4.21.-]

Immp2l; IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [KO:K09648] [EC:3.4.21.-]

Reference

Authors

Dalbey RE, Robinson C.

Title

Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.

Journal

Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4

Reference

Authors

Berks BC, Sargent F, Palmer T.

Title

The Tat protein export pathway.

Journal

Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x

Reference

Authors

Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.

Title

TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.

Journal

J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200

Reference

Authors

Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.

Title

TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.

Journal

J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200

Reference

Authors

Rapoport TA

Title

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.

Journal

Nature 450:663-9 (2007)
DOI:10.1038/nature06384

Reference

Authors

Flower AM

Title

The SecY translocation complex: convergence of genetics and structure.

Journal

Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001

Reference

Authors

Osborne AR, Rapoport TA, van den Berg B

Title

Protein translocation by the Sec61/SecY channel.

Journal

Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214

Reference

Authors

Paetzel M, Karla A, Strynadka NC, Dalbey RE

Title

Signal peptidases.

Journal

Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y

Reference

Authors

Paetzel M, Dalbey RE, Strynadka NC

Title

The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.

Journal

Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4

Reference

Authors

Ng SY, Chaban B, VanDyke DJ, Jarrell KF

Title

Archaeal signal peptidases.

Journal

Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0

Reference

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004

Reference

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

KO pathway

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