Nannospalax galili (Upper Galilee mountains blind mole rat): 103738985
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Entry
103738985 CDS
T03372
Symbol
Th
Name
(RefSeq) tyrosine hydroxylase
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00350
Tyrosine metabolism
ngi00790
Folate biosynthesis
ngi01100
Metabolic pathways
ngi04728
Dopaminergic synapse
ngi04917
Prolactin signaling pathway
ngi05012
Parkinson disease
ngi05030
Cocaine addiction
ngi05031
Amphetamine addiction
ngi05034
Alcoholism
Module
ngi_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
103738985 (Th)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
103738985 (Th)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
103738985 (Th)
09156 Nervous system
04728 Dopaminergic synapse
103738985 (Th)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
103738985 (Th)
09165 Substance dependence
05030 Cocaine addiction
103738985 (Th)
05031 Amphetamine addiction
103738985 (Th)
05034 Alcoholism
103738985 (Th)
Enzymes [BR:
ngi01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
103738985 (Th)
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Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
Metal_resist
LTP_2
Motif
Other DBs
NCBI-GeneID:
103738985
NCBI-ProteinID:
XP_008837425
UniProt:
A0A8C6S1Z6
LinkDB
All DBs
Position
Un
AA seq
493 aa
AA seq
DB search
MPTPSAASPQPKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREAAAAAATSEP
GDPLEAVVFEEREGKAVLNLLFSLRGSKSSSLSRAVKVFETFEAKIHHLETRPAQRSRAG
SPHLEYFVRFEVPSGDLVALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFD
PDLDLDHPGFSDQVYRQRRKLIAEIAFQYKQGEPIPHVEYTAEEIATWKEVYTTLKGLYA
THACREHLEAFQLLERFCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLA
FRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIE
KLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQD
QTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQD
ELHTLAHALSAIS
NT seq
1482 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccagcgctgcctcgccacagcccaaaggcttcagaagggctgtttccgag
ctggacgccaagcaagccgaggccatcatgtcccccaggttcattgggcgtcggcagagc
ctcatcgaggatgcccgcaaggagcgtgaggcggcggcagctgcggccacctcggagcct
ggggaccccctggaggctgtggtgtttgaggaaagggaagggaaggctgtgctcaacttg
ctgttctctctgaggggctccaaatcctcttcactgtcccgggctgtcaaagtgttcgag
acatttgaagccaaaatccatcacctggagacccggccggcccagaggtcacgggcaggg
agcccccacctggagtactttgtacgctttgaggtgcccagcggggacctggttgccctg
ctcagctccgtgcgcagggtgtcggacgatgtgcgcagtgccagagaggacaaggtcccc
tggttcccaaggaaagtgtcagagttggataagtgtcaccacctggttaccaagtttgac
cctgacctggacctggaccatccgggcttctctgaccaggtgtaccgccagcgccggaag
ctgatcgccgagatcgccttccagtacaagcagggtgaaccgattccccacgtggaatac
acggcagaggagattgccacctggaaggaggtctacaccacgctgaagggcctctacgct
acccacgcctgccgggagcaccttgaggctttccagctcctggaacgcttctgtggctac
agagaggacagcatcccacagctggaggatgtgtcccgcttcctgaaagagcggactggc
ttccagctgcggcccgtggccggcctgctgtctgcccgggatttcctggccagcttggct
ttccgagtgttccagtgcacacagtacatccgccacgcctcctcacctatgcactcacct
gagccggactgctgccacgagctgctgggacatgtacccatgctggccgatcgcacattt
gctcagttctcccaggacattggccttgcatcccttggggcctcagatgaggaaattgag
aaactgtccacggtgtactggttcactgtggagtttgggttgtgcaaacagaacggggaa
ctgaaggcttacggcgcggggctgctgtcttcctatggggagctcctgcactccctgtcg
gaggagcctgaggttcgggccttcgaccccgacacagcggctgtgcagccctaccaagat
cagacctaccagccggtgtactttgtgtctgagagcttcagcgatgccaaggacaagctc
aggaactatgcctcccggatccagcgtccattctctgtgaagtttgatccatacacgctg
gccattgatgtactggacagtccccacaccatccgacgctccctggagggggtccaggat
gagctgcataccctggcccatgccctgagtgccatcagttag
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