Nomascus leucogenys (northern white-cheeked gibbon): 100591963
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Entry
100591963 CDS
T03265
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
nle
Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00350
Tyrosine metabolism
nle00790
Folate biosynthesis
nle01100
Metabolic pathways
nle04728
Dopaminergic synapse
nle04917
Prolactin signaling pathway
nle05012
Parkinson disease
nle05030
Cocaine addiction
nle05031
Amphetamine addiction
nle05034
Alcoholism
Module
nle_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
nle00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
100591963 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100591963 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
100591963 (TH)
09156 Nervous system
04728 Dopaminergic synapse
100591963 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100591963 (TH)
09165 Substance dependence
05030 Cocaine addiction
100591963 (TH)
05031 Amphetamine addiction
100591963 (TH)
05034 Alcoholism
100591963 (TH)
Enzymes [BR:
nle01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
100591963 (TH)
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Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
100591963
NCBI-ProteinID:
XP_030667334
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Position
4:92004565..92012464
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AA seq
528 aa
AA seq
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MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGDPGPSLTGSPWPGTAAPAASYTSTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAAPLEPGEPLEAVAFEEKEGKAVLNLLFSLR
ATKPSALSRAVKVLETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVPRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
NT seq
1587 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccgacgccaccacgccacaggccaagggcttccgcagggccgtgtctgag
ctggacgccaagcaggcagaggccatcatggtaagagggcagggggacccagggcccagc
ctcacaggctctccgtggcctggaactgcagccccagctgcatcctacacctccaccccg
aggtccccgcggttcattgggcggaggcagagcctcatcgaggacgcccgcaaggagcgg
gaggcggcggtggcagcagcggctgctgcagcccccttggagcccggggaacccctggag
gctgtggcctttgaggagaaggaagggaaggcggtgctaaacttgctcttctccctgagg
gccaccaagccctcggcgctgtcccgagctgtgaaggtgttggagacgtttgaagccaaa
attcaccacctagagacccggcccgcccagaggccgcgagccgggggcccccacctggag
tacttcgtgcgcctcgaggtgccccgaggggacctggccgccctgctcagtggtgtgcgc
caggtgtcagaggacgtgcgcagccccgcggggcccaaggtcccctggttcccaagaaaa
gtgtcggagctggacaagtgtcatcacctggtcaccaagtttgaccctgacctggacttg
gaccacccgggcttctcggaccaggtgtaccgccagcgcaggaagctgattgctgagatc
gccttccagtacaggcatggcgacccgattccccgtgtggagtataccgccgaggagatt
gccacctggaaggaggtctacaccacgctgaagggcctctacgccacgcacgcctgcggg
gagcacctggaggcctttgctctgctggagcgcttcagcggctaccgggaagacaatatc
ccccagctggaggacgtctcccgcttcctgaaggagcgcacgggcttccagctgcggcct
gtggccggcctgctgtccgcccgggacttcctggccagcctggccttccgcgtgttccag
tgcacccagtatatccgccacgcgtcctcgcccatgcactcccctgagccggactgctgc
cacgagctgctggggcacgtgcccatgctggcagaccgcaccttcgcgcagttctcacag
gacattggcctggcgtccctgggggcctcggatgaggaaattgagaagctgtccacgctg
tactggttcacggtggagtttgggctgtgcaagcagaatggggaggtgaaggcctacggt
gccgggctgctgtcctcctacggggagctcctgcactgcctgtctgaggagcccgagatt
cgggccttcgaccctgaagctgcggccgtgcagccctaccaagaccagacataccagtca
gtctacttcgtgtctgagagcttcagtgacgccaaggacaagctcaggagctatgcctca
cgcatccagcgccccttctccgtgaagttcgacccgtacacgctggccatcgatgtgctg
gacagcccccaggccgtgcggcgctccttggagggtgtccaggacgagctggacaccctt
gcccatgcgctgagtgccattggctag
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