KEGG   Ovis aries (sheep): 114108679
Entry
114108679         CDS       T03117                                 
Name
(RefSeq) steroid 21-hydroxylase isoform X1
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
oas  Ovis aries (sheep)
Pathway
oas00140  Steroid hormone biosynthesis
oas01100  Metabolic pathways
oas04925  Aldosterone synthesis and secretion
oas04927  Cortisol synthesis and secretion
oas04934  Cushing syndrome
Module
oas_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:oas00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    114108679
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    114108679
   04927 Cortisol synthesis and secretion
    114108679
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    114108679
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:oas00199]
    114108679
Enzymes [BR:oas01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     114108679
Cytochrome P450 [BR:oas00199]
 Cytochrome P450, animal type
  CYP21 family
   114108679
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 114108679
NCBI-ProteinID: XP_027814595
LinkDB
Position
20:complement(26393340..26403007)
AA seq 497 aa
MVLAGLLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLLQPNLPIHLLSLTQKLGPV
YRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKA
HKKLTRSALLLGTRSSMEPWVEQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFG
DKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRLFPNPGLWRLKKAIENRDHMVEKQ
LRRHKESMVAGQWRDMMDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTL
SWAVAFLLHHPEIQRRLQEELDRELGPGASCSGVTYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANTSALA
FGCGARVCLGESLARLELFVVLLRLLQAFTLLPPPGGALPSLQPDPYCGVNLKVQPFQVR
LQPRGVEAGAWESTSAQ
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggtccttgcagggctgctgctgctgctgctcaccctgctagccggcgctcacctgctg
tggggccggtggaagctcagaaacctccacctcccacctctggtccccggcttcctgcac
ctgctgcagcccaacctccccatccatctgctgagcctgactcagaaactcgggcctgtc
tacaggcttcgccttgggctgcaagaggtggtggtgctaaactccaagaggaccatcgag
gaggctatgatcaggaagtgggtggactttgccggcagaccccaaataccatcctacaag
ctggtgtctcagcgctgccaggacatctctctgggggactactctctgctctggaaggcc
cacaagaaactcacccgctcagccttgctgctgggcacccgcagctccatggaaccctgg
gtggagcagctgacccaggagttttgtgagcgcatgagagtccaggccggtgcccccgtg
accatccagaaggaattctctctcctcacttgcagcatcatctgttacctcacttttgga
gacaaggaggacaccttagtacatgcctttcacgactgtgttcaggacttgatgaagacc
tgggaccactggtccatccagattttggacatggttccttttctcaggctcttccccaac
cctgggctctggaggctgaagaaggccatagagaacagggaccacatggtggagaagcag
ctgaggcgccacaaggagagcatggtggccggccagtggagggatatgatggactacatg
ctccagggggtagggaggcaaagagtagaagagggcccgggacagctcctggaaggacac
gtgcacatgtctgtggtggaccttttcatcgggggcactgaaaccacggccagcaccctc
tcctgggcggtggccttcctacttcaccaccccgagattcagcgccgccttcaggaggag
ttggatcgagagctgggccccggagcctcgtgctccggagtcacttacaaggaccgtgct
cggcttcctctgctcaacgccaccatcgcggaggtgctgcgcctgcggccggtcgtgccc
ctggccttgcctcaccgcaccacgcggcctagcagcatcttcggctacgacatccctgag
ggcatggtcgttatccccaacctccaaggtgcccacctggatgagaccgtctgggagcag
ccgcatgagttccggccggaccgcttcctggagccgggcgcgaacaccagcgcgctggcg
tttggctgcggggcgcgcgtgtgcctgggcgagtcgctggcgcgcctggagctcttcgtg
gtgctcctgcgactgctgcaggccttcactctgctgccgccgcccgggggcgccctgccg
tcgctgcagccggatccctactgcggcgtcaacctcaaggtccagcctttccaggtgcgg
ctgcagccccggggagtggaggccggggcctgggagagcaccagtgcccagtga

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