KEGG   Otolemur garnettii (small-eared galago): 100963190
Entry
100963190         CDS       T07855                                 
Name
(RefSeq) steroid 21-hydroxylase isoform X1
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
oga  Otolemur garnettii (small-eared galago)
Pathway
oga00140  Steroid hormone biosynthesis
oga01100  Metabolic pathways
oga04925  Aldosterone synthesis and secretion
oga04927  Cortisol synthesis and secretion
oga04934  Cushing syndrome
Module
oga_M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
oga_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:oga00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100963190
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    100963190
   04927 Cortisol synthesis and secretion
    100963190
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100963190
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:oga00199]
    100963190
Enzymes [BR:oga01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     100963190
Cytochrome P450 [BR:oga00199]
 Cytochrome P450, animal type
  CYP21 family
   100963190
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 100963190
NCBI-ProteinID: XP_003789336
Ensembl: ENSOGAG00000009619
VGNC: 82737
LinkDB
Position
Unknown
AA seq 489 aa
MLFLGLLLLLPLMAGACLLWGQWKLRSLHLPPLAPGFLHLLRPNLPVYLLGLTQKFGPIY
RLRLGLQYVVVLNSKRTIEEAMVRKWVDFAGRPQMLSYKLASQGYPDLSLGDYSLLWKAH
KKLTRSALLLGIRNSMETVVEKLTQEFFERLRTQASAPVAIQKEFSFLTCSIICYLTFGD
KIKEDNLIHAFYDWVQEVMKIWDHWSIQILDIIPFLRFFPNPGLWKLQQTIEKRDYFVEK
QLRWHKESLVAGQWRDMMDYMLQEMALPRVEEGSGQLLEGHVHMAAVDLLIGGTETTATT
LSWAVAFLLHHPEIQQRLQEELDLQLGSSASGSWVSYKDRERLPLLNATIAEVLRLRPVV
PLALPHRTTQLSSIFGYDIPEGTVVIPNLQGAHLDDTVWEQPHEFWPDRFLKPGKSPRVL
AFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPAEGALPSLQPQPYFTTNLKVQPFQV
RLQPRGVGP
NT seq 1470 nt   +upstreamnt  +downstreamnt
atgctgttcctagggctgctgctgctgctgcccctgatggcaggtgcctgcctgctgtgg
ggccagtggaagctcaggagcctccacctcccgcctcttgccccgggattcctgcacctg
ctgcggcccaacctgccagtgtatctgcttggcctgacccagaaatttgggcctatctat
aggctccgcctggggctgcagtatgtggtggtgttgaactccaagaggaccattgaggaa
gccatggtcagaaagtgggtggactttgccggcagaccccagatgctgtcctacaagcta
gcatctcagggttacccagacctgtcgctaggggactactccctgctctggaaggcccac
aagaaacttacccgctcagccctgttgctgggcattcgcaactctatggagactgtggtg
gagaagctgacccaggagttctttgagcgcctgagaacccaggccagcgcccctgtggcc
attcagaaggaattctctttcctcacctgcagcatcatctgctacctcacctttggagac
aagatcaaggaggacaacttgatacatgccttttacgactgggtccaggaggtgatgaaa
atctgggaccactggtccatccaaattttggacataattccttttctcaggttctttccc
aatccgggtctttggaagctgcagcaaactatagagaagagggactactttgtagagaag
cagctgaggtggcacaaggagagcctggtggcaggacagtggagggacatgatggactac
atgctccaagagatggcactgccaagagtggaagagggcagtggacagctccttgaaggg
cacgtgcacatggctgcagtggaccttctcattggtggcactgagaccacagcaaccacc
ctctcctgggctgtggctttcttgcttcaccatcctgagattcagcagcgactacaggag
gagctagatcttcaactgggctccagtgcttctggctcctgggtctcctacaaggaccga
gagcggctgcccttgctcaatgccaccattgcggaggtattgcgcctacggcctgttgtg
cccttggccttgccccaccgcaccacgcagctcagcagcatctttggctatgacatcccc
gagggcacggttgtcatccccaatctccaaggtgcccaccttgatgacactgtctgggag
cagccacatgagttttggccagaccgcttcctgaagccgggaaagagccccagagtgctg
gcctttgggtgcggggcccgtgtgtgtctgggtgagccgctcgcacgcctggagctcttt
gtggtgctggcccgactactgcaggccttcacactgctgccaccagctgaaggtgccctg
ccctctctgcagccccagccctacttcaccaccaacctcaaggtacagcctttccaagtg
cggctgcagccccggggcgtgggaccctag

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