KEGG   Ochotona princeps (American pika): 101520175
Entry
101520175         CDS       T07609                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi00562  Inositol phosphate metabolism
opi01100  Metabolic pathways
opi01521  EGFR tyrosine kinase inhibitor resistance
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04015  Rap1 signaling pathway
opi04020  Calcium signaling pathway
opi04062  Chemokine signaling pathway
opi04064  NF-kappa B signaling pathway
opi04066  HIF-1 signaling pathway
opi04070  Phosphatidylinositol signaling system
opi04072  Phospholipase D signaling pathway
opi04360  Axon guidance
opi04370  VEGF signaling pathway
opi04613  Neutrophil extracellular trap formation
opi04650  Natural killer cell mediated cytotoxicity
opi04658  Th1 and Th2 cell differentiation
opi04659  Th17 cell differentiation
opi04660  T cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04666  Fc gamma R-mediated phagocytosis
opi04670  Leukocyte transendothelial migration
opi04722  Neurotrophin signaling pathway
opi04750  Inflammatory mediator regulation of TRP channels
opi04919  Thyroid hormone signaling pathway
opi04933  AGE-RAGE signaling pathway in diabetic complications
opi04935  Growth hormone synthesis, secretion and action
opi05012  Parkinson disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05135  Yersinia infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05170  Human immunodeficiency virus 1 infection
opi05171  Coronavirus disease - COVID-19
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05206  MicroRNAs in cancer
opi05214  Glioma
opi05223  Non-small cell lung cancer
opi05225  Hepatocellular carcinoma
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
opi05417  Lipid and atherosclerosis
Module
opi_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:opi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101520175 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101520175 (PLCG1)
   04014 Ras signaling pathway
    101520175 (PLCG1)
   04015 Rap1 signaling pathway
    101520175 (PLCG1)
   04370 VEGF signaling pathway
    101520175 (PLCG1)
   04064 NF-kappa B signaling pathway
    101520175 (PLCG1)
   04066 HIF-1 signaling pathway
    101520175 (PLCG1)
   04020 Calcium signaling pathway
    101520175 (PLCG1)
   04070 Phosphatidylinositol signaling system
    101520175 (PLCG1)
   04072 Phospholipase D signaling pathway
    101520175 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101520175 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    101520175 (PLCG1)
   04660 T cell receptor signaling pathway
    101520175 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    101520175 (PLCG1)
   04659 Th17 cell differentiation
    101520175 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    101520175 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    101520175 (PLCG1)
   04670 Leukocyte transendothelial migration
    101520175 (PLCG1)
   04062 Chemokine signaling pathway
    101520175 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101520175 (PLCG1)
   04919 Thyroid hormone signaling pathway
    101520175 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101520175 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101520175 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    101520175 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101520175 (PLCG1)
   05206 MicroRNAs in cancer
    101520175 (PLCG1)
   05205 Proteoglycans in cancer
    101520175 (PLCG1)
   05231 Choline metabolism in cancer
    101520175 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101520175 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101520175 (PLCG1)
   05214 Glioma
    101520175 (PLCG1)
   05223 Non-small cell lung cancer
    101520175 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101520175 (PLCG1)
   05171 Coronavirus disease - COVID-19
    101520175 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101520175 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101520175 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101520175 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    101520175 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101520175 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101520175 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101520175 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:opi04131]
    101520175 (PLCG1)
Enzymes [BR:opi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101520175 (PLCG1)
Membrane trafficking [BR:opi04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101520175 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101520175 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 101520175
NCBI-ProteinID: XP_004585867
LinkDB
Position
4A:26303358..26335619
AA seq 1290 aa
MAGAGSPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASAVRT
GERPDLCRVALPEFQQFLLEFQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDTVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPMW
PPKSFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFGSTSLRERGSEASGQLFHGRAREGSFEARYQQPFED
FRISQEHLADHCDSRERRARRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgggtccccctgcgccaatggctgcggtcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgatattcgtgaaatcaaggag
atccgtccgggcaagacctcacgggactttgatcgctatcaggaggaccctgcttttcga
ccagaccagtcgcactgctttgtcatcctctatgggatggaattccgcctgaagaccctg
agcttgcaagcaacgtctgaagatgaagtgaatatgtggatcaagggcttaacttggctg
atggaggacacgttgcaggcggcgacaccactgcagattgagaggtggcttcggaagcag
ttctattcagtggatcggaatcgtgaggatcgaatatcagccaaagatctgaagaacatg
ctatcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcaacgtagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgctgtgaggacg
ggggagcgaccagatctttgccgagtggcccttcctgagtttcagcagttccttctcgag
ttccagggggagctctgggccgtcgaccggctccaggtgcaggagttcatgctcagcttc
ctccgggaccccttgcgagagattgaggaaccatactttttcctggatgagtttgtcacc
ttcctgttctctaaagagaacagcgtgtggaactctcagctggacacagtgtgtccagac
accatgaacaaccctctctcccactactggatctcatcctcacacaacacgtacctgact
ggggatcagttctccagcgaatcctccctggaagcctatgctcgctgcctgcggatgggc
tgccgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttatcat
ggacacacccttaccaccaagatcaagttctcagatgtcctgcataccatcaaggaacat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtactttaagaaggtgcttggggacacactcctaactaag
cctgtggacattgcagccgatgggctgccctcacccaaccaactcaagaggaagatcctc
attaagcacaagaagctggctgagggcagcgcttatgaggaggtgcccacctctgtgatg
tactctgagaatgacatcagcaactccatcaagaatggcatcctctacttggaggaccct
gtgaaccatgaatggtatccccactactttgttctgaccagcagcaagatctattactct
gaggaaaccagcagcgaccagggcaacgaggatgaggaggaacccaaggaggccagtggc
agcacagagctgcactccaatgagaaatggttccatggaaagcttggagcagggcgcgac
gggaggcacatcgccgagcgcctgctcacagagtactgcatcgagactggggcccctgac
ggctccttcctggttcgggagagcgagacctttgtgggcgactacacgttgtctttctgg
cggaatgggaaagtccagcactgccgtatccactcaagacaagatgctgggacccccaag
ttcttcttgacagacaatcttgtcttcgattccctctatgatcttatcacacactaccag
caagttcccctgcgctgcaatgagtttgagatgcgtctgtcagagcccgttccacagacc
aatgcccacgagagcaaagagtggtaccacgcgagtctgaccagggcacaggctgagcat
atgctgatgcgcgtgccccgtgatggagccttcctggtgcggaaacggagtgagcccaac
tcctatgccatctcctttcgggctgagggcaagatcaagcattgccgcgtccagcaggaa
ggccagacagtgatgctggggaactcggagtttgacagccttgtggacctcatcagctac
tatgagaagcacccactgtaccgtaagatgaagctccgctatcccatcaacgaggaggca
ctggagaagattggcacagctgagcctgactacggggccttgtatgagggccggaaccct
ggcttttacgtggaggcaaaccctatgccgacttttaagtgtgcagtcaaagccctcttt
gactacaaggcgcagagagaggatgagctgactttcaccaagagtgcaatcatccagaat
gtagaaaagcaagagggaggctggtggcgaggggactatggcgggaagaagcaactatgg
ttcccttcaaactacgtggaagagatggtcagtccggcagccctggagcctgaaagggag
cacctggatgagaacagtcctctgggggacttgctgcggggggtcttggatgtgccagct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtgttctccatcagc
atggcctcggtggcccactggtctctggatgttgctgctgattcacaggaagaactacag
gactgggtgaaaaagatccgtgaggtggcccagactgcagatgctaggctcactgagggg
aagatgatggaacggaggaagaagattgctctggaactctctgagcttgtcgtctactgc
cgacctgttcccttcgatgaagagaagattggcacagagcgagcttgttaccgggacatg
tcatccttcccggaaaccaaggctgagaagtatgtgaacaaggccaaaggtaagaagttc
ctccagtacaatcgcctgcagctctcccgcatctaccccaagggccagagactggactcc
tccaattatgaccctctgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagaccccagataagcctatgcagatgaaccaggccctcttcatggcaggcgggcactgt
ggctacgtgctgcagcccagcaccatgcgggatgaggcctttgacccgtttgacaagagc
agtctccggggactggagccctgtgccatctgcatcgaggtgctgggggcccggcatctg
ccgaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcagag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactgaacccaatgtgg
ccccccaagtccttccacttccagatcagcaaccctgagtttgccttcctgcgctttgtg
gtatatgaagaagacatgtttagcgaccagaacttcttggctcaggctactttcccagtg
aaaggcctgaagacgggataccgagcggtgcctttgaagaacaactacagtgaggacctg
gagttggcgtctctgctgatcaagatcgacatttttcctgctaagcaggagaatggtgac
ctcagtcccttcggtagcacatccctgcgagaacggggttcagaggcctccggccagctg
tttcacggccgagcccgcgaaggttcctttgaagcccggtaccagcagccgtttgaggac
ttccgcatttcccaggagcatcttgcagaccactgtgacagtcgagaacgaagggcaagg
aggactcgggtcaatggagacaaccgcctctag

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