Ochotona princeps (American pika): 101521583 Help Entry 101521583         CDS       T07609                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism opi  Ochotona princeps (American pika) Pathway opi04020   Calcium signaling pathway opi04371   Apelin signaling pathway opi04713   Circadian entrainment opi04730   Long-term depression opi04921   Oxytocin signaling pathway opi05017   Spinocerebellar ataxia opi05020   Prion disease opi05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:opi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101521583 (RYR1)    04020 Calcium signaling pathway     101521583 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101521583 (RYR1)   09156 Nervous system    04730 Long-term depression     101521583 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     101521583 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     101521583 (RYR1)    05020 Prion disease     101521583 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     101521583 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:opi01009]     101521583 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:opi04147]     101521583 (RYR1)    04040 Ion channels [BR:opi04040]     101521583 (RYR1) Protein phosphatases and associated proteins [BR:opi01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      101521583 (RYR1) Exosome [BR:opi04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    101521583 (RYR1) Ion channels [BR:opi04040]  Voltage-gated cation channels   Ryanodine receptor    101521583 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 DNA_pol_phi CDC45 Motif Other DBs NCBI-GeneID:  101521583 NCBI-ProteinID:  XP_004595226 LinkDB All DBs Position 5:complement(10064020..10176254) Genome browser AA seq 5037 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSC LTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDD QRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VVDASKAHTKATSFCFRISKEKLDTAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTAGLYNQFIKGLDS FSGKPRGSGPPAGSALPIEAVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLTLVLNCIDRLNVYTTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALF STNLDWVVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYG KWYFEVMVDEVTPFLTAQPTHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLRKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKS YAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFG RPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARM DGTVDTPPCLRLAHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAE DEARAAEPDPDYENLRRSAGGWGEADGGKEGTAKEGTAGGTPQPGVEAQSVRAENEKDAT TEKNKKRGFLFKAKKAAMMTQPPATPALPRLPHDVVPADNRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDF VSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPISWSRMPNHFLQVDTRRA GERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDARLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTP ETRAITLFPPGRKAENGARRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLS PAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFGDEDV KQILKMIEPEVFKEEEEEEEEEEEEEEEEDEEEKEEDEEEEEQEKEDDEKEDEEAAEGEK EEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYH LLMKAFTMSAAETARRTREFRSPPQEQINMLLHFKDGADEEECPLPEEIRQDLQDFHQDL LTHCGIQLEGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEEPPAEESKPQSLQELV SHMVVRWAQEDYVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLEC LGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGG ETKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSSIGLGMQGSTPLDVAAA SVIDNNELALALQEQDLEKVVSYLAGCGLQSCSMLLAKGYPDIGWNPCGGERYLDFLRFA VFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVR RDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILR SLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFL LHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIM VDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAK MPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRM AMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKF AEYTHEKWAFDKIQNSWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIA WEWTIEKAREGEEEKTEKKKTRKISQSAQTYDAREGYNPQPPDLSGVTLSRELQAMAEQL AENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVT RGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFF AKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFG TDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQA RTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT KNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEE MCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPSPALPS GAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHF IPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDN NRAHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKM AKAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIALAKT RYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEGTDDPEKIVRRVQE VSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYK AAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDE DYLYMAYADIMAKSCHLEEGGENGEAEEEEVEVSFEEKEMEKQRLLYQQSRLHNRGAAEM VLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQT CSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNND FQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVA KQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLD LQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQ DYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQEPARD IGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGSSRRIERIYFEIS ETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEP EADEDEGAAEEGAEEGAAGPEGAAGTAAAGATTRLSALAARALRGLSYRSLRRRVRRLRR LTAREAATALAALLWAVVARAGAAGAGAAAGALHLLWGSLFGGGLVEGAKKVTVTELLAG MPDPTGDEVHGEQPAGPGGDADGAGEGEGEGDTAEGAGDEEVAGHEAGPGGAEGAVAVTE GGPFRPEGPGGLGDMGDTTPVEPPTPEGSPILKRKLGVDGEEEEELIPEPEPEPEPEPEK ADEENGEKEEVPETPPEPPKKAPPPPPAKKEEARGVGMEFWGELEVQRVKFLNYLSRNFY TLRFLALFLAFAINFILLFYKVSDSPPGEDDFEGSAAGDLSGAGSGGGSGWGSGPGEEAE GDEDDNMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARK LEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAEL LGMDLASLEITAHNDRKPDPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSL LGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR KFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF FFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTL EEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15114 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggacgaagtccagttcctgcggacggacgatgaggtg gtcctgcagtgtagcgccacagtcctcaaggagcagctgaagctgtgcttggcggccgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaacgcccagaatgtgccccct gatctggccatctgctgcttcatcctggagcagtccctgtcggtccgtgccctgcaggag atgctggccaacacggtggaggctggcgtggagtcatcccagggcgggggacacaggaca ctcctgtatggccatgccatcctgctccggcatgcacacagccgcatgtacctgagctgc ctcactacctcacgctccatgactgacaagctggccttcgatgtggggctgcaagaggat gcgacaggagaggcctgttggtggacgatgcacccagcctccaagcagagatctgaaggc gagaaggttcgtgtgggtgatgacatcatcctcgtcagtgtttcctctgagcgctacctg cacctgtcgacggccagcggggagctccaggttgacgcctccttcatgcagacactatgg aacatgaaccccatctgctcctgttgtgaagagggctatgtgacagggggccacgtcctc cgcctcttccatggacatatggacgaatgcttgactatttcagctgccgacagtgatgac cagcgcaggcttgtctattacgaggggggagctgtgtgcacacatgcccgctccctctgg agactggagccactgagaatcagctggagtgggagccacctgcgctggggccagccgctg cgaatccgacatgtgaccactgggcggtacctggcgctcactgaagatcagggtctggtg gtcgtcgacgccagcaaggcccacaccaaggctacctctttctgcttccgcatctccaag gagaagctggatacagcccccaagcgagatgtggagggcatggggccccctgagatcaag tacggggagtcactgtgttttgtgcagcatgtggcctcgggcctgtggcttacctacgcg gccccagaccccaaggcgttgcggctgggcgtgctgaagaagaaggccatgttgcaccag gaaggccacatggacgatgcgctgtccctgacccgctgccagcaggaggagtcgcaggct gcccgcatgatccacagcacagctggcctctacaaccagttcatcaagggcctggacagc ttcagcgggaagccacggggctcggggccgccggctggctctgcgctgcctatcgaggcc gtcatcctgagcctgcaggacctcatcggctacttcgagccgccgtcggaggagttgcag cacgaggaaaagcagagcaagctgcggagcctgcgcaaccgccagagcctcttccaggag gagggcatgctcaccctagtcctcaactgcattgaccgcctgaatgtctacacaactgct gcccactttgccgagtatgcaggggaagaggcggctgagtcctggaaggagattgttaac ctactctacgagctcctggcctctctgatccgtggcaaccgtgccaactgtgccctcttc tccaccaacttggactgggtggtcagcaagctggaccgactggaggcctcgtctggcatc ctggaagtgctgtactgtgtcctgattgagagccccgaggtgctgaacatcatccaggag aaccacatcaagtccatcatctccctgctggacaagcacgggagaaaccacaaggttctg gatgtgctgtgctccctgtgtgtgtgcaatggtgtggctgtgcgctccaaccaagatctc atcactgagaatctgctcccgggccgtgagcttctgctgcagaccaacctcatcaactat gtcaccagcatccgccccaacatctttgtgggccgagccgagggctccacgcagtatggc aaatggtactttgaggtgatggtggacgaggtgactccctttctcacagcacagccgacg cacctgcgggtgggctgggccctcacggagggctacagtccctaccctggcggtggcgag ggctggggcggcaacggggtcggtgatgacctctactcctacggctttgacgggctgcac ctctggacaggacatgtggcacgtccagtgacttctcctgggcagcacctgctggccccc gaggatgtggtcagctgctgcctggacctcagtgtcccatccatctccttccgcatcaat ggctgccccgtgcaaggtgtctttgaggccttcaacctcgacgggctcttctttccggtc gtcagcttctccgctggtgtcaaggtgcggttccttctcggtggccgccacggtgaattc aagttcctccccccacccggctatgccccatgccacgaggctgtgctccctcgagagcga ctccatctggaacccatcaaggagtaccggcgggaagggccccggggcccccacctggtg ggccccagccgctgcctctcgcacactgactttgtgccctgccctgtggacactgtccag attgtcctgcctccccacctggagcgcatccgtgagaagctggcagagaacatccatgag ctgtgggctctgacgcgcatcgagcaaggctggacctatggcccggttcgggatgacaac aagaggctgcacccgtgtctcgtggatttccacagcctcccagagcccgagaggaattac aacctgcagatgtcgggcgagacactcaagaccttgctggcgctgggctgccacgtgggc atggccgatgagaaagcagaggacaacttgaggaagacaaagctccccaagacgtacatg atgagcaatggatacaagccagccccgctggacctgagccatgtgcggttgacgcctgcc cagaccacgctggtggaccggctagcagagaacgggcacaatgtgtgggcacgagaccgt gtggctcaaggctggagctacagcgcggtacaggacatcccagctcgccggaacccccgt cttgtgccctaccgcctgctagatgaggccaccaaacgcagcaaccgggacagcctctgc caggctgtgcgcaccctgctgggctatggctacaacatcgagccgcctgaccaggagccc agtcaggtggagaaccagtctcgctgggatcgggtgcgcatcttccgggcagagaaatcc tacgcggtacagagtggccgctggtactttgagttcgaggctgttaccacgggcgagatg cgagtgggctgggccaggcctgagctgcggcctgacgtggagctgggagctgatgagctg gcctatgtcttcaacgggcaccgcggccagcgctggcacctgggcagtgaaccatttggg cgtccctggcagtcaggtgatgttgttggctgcatgatcgacctcactgagaacaccatt atcttcaccctcaatggcgaggtcctcatgtctgactcaggctccgaaactgccttccgt gagattgagattggagacggcttcctgcccgtctgtagcttgggacccggacaagtgggt cacctgaacctgggccaggatgtgagctctctgcgcttctttgccatctgcggcctgcag gaaggctttgagccattcgccatcaacatgcagcgcccagtcaccacatggttcagcaaa agccttcctcagtttgagcctgtgccccctgagcacccccactatgaggtggcacgcatg gatggcactgtggacacacccccctgcctacgcctggcccaccgcacttggggctcccag aacagccttgtggagatgttgttcctccgcttgagtctcccagtccagttccaccagcac ttccggtgcaccgcgggggccacacctctggctcctcctggcctgcagccgccagcagag gatgaggcccgcgcagcagaaccagacccagattatgaaaacctgcgccgctcagccgga ggttggggcgaggctgacggaggcaaggagggaactgccaaggaggggacagccggaggc accccgcagcctggggtggaggcccaatctgtgagggcggagaatgaaaaggatgccaca actgagaagaacaagaagagagggttcttgttcaaggccaagaaagccgccatgatgacc cagcccccagccacccctgctctgccccggctccctcacgatgtggtgcctgccgacaac cgtgatgaccctgagatcatcctcaacaccaccacgtactactactctgtgagggtcttt gctggtcaggagcccagctgcgtgtgggtgggctgggtcacccccgactaccatcagcac gacatgaactttgacctcagcaaggtccgggcagtgacggtgaccatgggagatgaacaa ggcaacgtccatagcagcctcaagtgcagcaactgctacatggtgtggggaggggacttc gtgagccccggccagcagggccggatcagccacacagaccttgtcattgggtgcctggtg gacttggctactggcttaatgaccttcacggccaatggcaaagagagcaacacctttttc caggtggagcccaacacgaagctctttcctgctgtctttgtcctgcccactcaccagaat gtcattcagtttgagctggggaagcagaagaacatcatgccgctgtcagccgccatgttc ctgagtgagcgcaagaacccagcgccgcagtgcccgccacggctggaggtgcagatgctg atgcccatctcctggagccgcatgcccaaccatttcctgcaggtggacacgcggcgcgcc ggcgagcgccttggctgggcggtgcagtgccaggagcccctgaccatgatggcactacac atcccggaggagaaccggtgcatggacatcctggagctgtcggagcgcctagacctgcag cgtttccattcgcacaccctccgcctgtatcgcgcggtgtgcgccctgggcaacaaccgc gtggctcatgctctgtgcagccacgtggaccaggcgcagctgctgcacgccctggaggat gcgcgcctgcccggccccctgcgtgcaggctactacgacctcctcatcagcatccacctg gagagtgcctgccgcagccgccgctccatgctctcggagtacattgtacccctcacaccc gagacccgcgccatcacgctcttcccccctggacggaaggcagaaaacggggcccgccgc cacggcctgcccggcgtgggagtcaccacctcgctgaggcctccacaccatttctctcct ccgtgtttcgtggccgccctgccagctgcgggagtcgcagaagcccctgcccgcctcagc cccgccatccctctggaagctctgcgggacaaggcgctgagaatgctgggggaggccgtg cgcgacggtgggcagcacgcccgcgaccctgtcgggggctccgtggagtttcagttcgtg ccggtgctcaagcttgtgtctacgctgctggtgatgggcgtctttggcgatgaggatgtg aagcagatcttaaagatgatcgaacctgaagttttcaaggaggaagaagaggaggaagag gaggaggaagaagaggaggaggaggaagatgaagaggaaaaggaagaggatgaggaggaa gaggaacaggaaaaggaagatgacgaaaaagaagatgaggaggcagcagaaggggaaaaa gaagaaggcttggaggaggggctgctccaaatgaagctgccagagtctgtgaagttacag atgtgccacctcctcgagtatttctgtgaccaagagttgcagcatcgcgtggagtccctg gctgccttcgctgagcgctatgtggacaagctccaggccaaccagcggagccgctaccac ctcctgatgaaagccttcaccatgagtgctgctgagactgcgaggcgcacccgcgagttc cgctccccaccccaggagcagatcaacatgctgttgcacttcaaagatggtgcagatgag gaagaatgtccactcccagaggagattcggcaggacctgcaggacttccatcaagacctg ctgacacactgtggaattcagctggagggggaggaggaagagccagaggaggagaccacg ctgggcagccgcctgatgagcctgttggagaaggtgcggctggtgaagaagaaggaggag aaacccgaggaggagccaccagcagaggagagcaaaccccagtccctgcaggagctggtg tcccacatggtggtgcgctgggcccaggaagactacgtgcagagcccggagctggtgcgg gccatgtttagcctcctccaccggcagtacgatggactcggcgagctgctgcgtgccctg ccccgggcatacaccatctcgccatcctcagtggaggacaccatgagcctgctcgagtgc ctcggccagatccgctccctgctcatcgtgcagatgggcccccaggaggagaacctcatg atccagagcattgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatg agggccctgggcatgcacgagaccgtcatggaggtcatggtgaacgtgctggggggtggt gaaaccaaggagatccgcttccccaagatggtgaccagctgctgccgcttcctctgctac ttctgccgcatcagcaggcagaaccagcgctccatgtttgaccacctgagctacctgctg gaaaacagcagcattggtctggggatgcaaggttccacacccctggacgtggctgccgcc tctgttattgacaacaacgagttagccttggcgttgcaggagcaggacttggaaaaggtc gtatcctatctggcaggctgcggcctgcagagctgttcgatgctgctggccaaaggctac cctgacatcggctggaatccctgcggtggcgagcgctacctggacttcctgcgctttgct gtcttcgtcaacggtgagagcgtggaggagaatgccaacgtggtggtgcggctgctcatt cgcaaacctgagtgctttgggcctgccctgcgtggtgagggtggctctgggctgctggcc gccattgaggaggccattcgcatctcggaggaccctgcaagggatggcccaggcgtccgc agggaccggcggcgcgaacactttggggaggagccccctgaagaaaatcgcgtgcacctg ggccacgccatcatgtccttctatgctgccctgatcgacctgctgggccgctgcgcacca gagatgcatctcatccaagccggcaagggtgaagccctgaggatccgtgccatccttcgc tccctcgtgcccctagacgatctcgtgggcatcatcagtctccccctgcagatcccaacc ctgggcaaagatggggctctggtgcagcccaagatgtcggcgtccttcgtgccggaccac aaggcttccatggtgctcttcctggaccgtgtgtatggcatcgagaaccaggacttcctg ctgcatgtgctggatgtgggcttcttgcctgacatgagggctgcagcctcgctggacacg gccaccttcagcaccacggagatggctctggcactgaaccggtacctgtgcctggctgtg ctgccgctcatcaccaagtgcgcgccactctttgcgggcactgagcaccgcgccatcatg gtggactccatgctgcacaccgtgtaccgcctgtcgcggggccgctcgctcaccaaggcg cagcgtgacgtcatcgaggactgcctcatggctctgtgcaggtacatccgcccatccatg ctgcagcacctgctgcggcgcctggtgttcgatgtgccaatcctgaacgagtttgccaag atgccgctcaagctcctcaccaaccactatgagcgctgctggaagtactactgcctcccc acgggctgggctaactttggggtcacctcagaggaggagctgcacctcacacgcaaactc ttctggggcatattcgactctctggcccataagaagtacgaccaggagctgtaccgcatg gccatgccttgtctgtgtgccatcgcgggggccctgccccccgactacgtggatgcctcc tattcttccaaggcagagaagaaggccacagtggacgctgaaggcaactttgaccctcgg ccggtggagaccctcaatgtgatcatcccggagaagctggactccttcatcaacaagttt gcagagtacacacacgagaagtgggccttcgacaagatccagaacagctggtcctatgga gagaacatagatgaagaactgaagacccaccccatgctgaggccctacaagacgttttca gagaaggacaaagagatttaccgctggcccataaaggaatccttgaaggccatgatcgcc tgggagtggacgatagagaaggcccgggagggtgaggaggagaagacagagaagaaaaag acacgcaagatttcccagagtgcccagacctatgatgcccgagaaggctacaacccccag ccccctgacctcagtggagtcaccctgtcccgggagctgcaggccatggcagaacaactg gcagaaaattaccacaacacgtgggggcgaaagaagaagcaggagctggaagccaagggt ggtgggacccacccgctgctggtcccctacgacacgctcacagccaaggagaaagcacga gatcgagagaaggcccaggagctgctcaagttcctgcagatgaacggctatgcggtcacc agaggcctgaaggacatggagctggacacgtcttctatcgagaagcggttcgcctttggc ttcctgcagcagttgctgcgctggatggacatttcccaggagtttatcgcccacctggag gctgtggtcagcagcggacgagtggagaagtccccacatgagcaggagattaaattcttt gccaagatcctgctccccttgatcaaccagtacttcaccaaccactgcctctacttcctg tccacgcctgccaaagtgctgggcagtgggggccacgcctccaacaaggagaaggaaatg atcaccagcctcttctgtaagctggccgcccttgttcgccaccgagtctctctctttggc acggacgccccagccgtagtcaactgtcttcacatcctggcccgctccctggatgccagg acggtgatgaaatcaggccccgagatcgtcaaggccggcctccgctccttctttgagagt gcctcagaggacattgagaagatggtggagaacctgcggctgggcaaggtgtcccaggca cgcacgcaggtgaagggcgtgggccagaacctcacctacaccaccgtggccctgctgcct gtcctcaccacgctcttccagcacatcgcgcagcaccagttcggagacgacgtcatcttg gatgacgttcaagtgtcctgctaccgaacactgtgcagcatctactctctgggaaccacc aagaatacttatgtggaaaaactgcgaccagccctcggggagtgcctggcccgcctagca gccgccatgcccgtggccttcttggagcctcagctgaacgagtataatgcctgctcggtg tacaccaccaagtcccccagggagcgagccatcctggggcttcccaacagcgtggaggag atgtgccctgacatccctgtgctggagcggctcatggcagacatcggggggctggccgag tccggggctcgctacacggagatgccacatgtcattgagatcacactgcccatgctgtgc agttacctgccccgctggtgggagcgcgggcctgaggcgccctctcctgcattgccctcc ggggcgcccccgccctgcactgcggtcacctctgaccacctcaactccctgttgggcaac atcctgcgcatcattgtcaacaacctgggcatcgacgaagccacctggatgaagcggctt gctgtgtttgcccagcccatcgtgagccgggcacggcctgagctcctgcactctcacttc atccccaccattgggcggctgcgcaagcgggcgggcaaggtcgtagccgaagaggagcag ctgcggctggaggccaaggcggaggccgaggagggcgagctcctggtgcgggatgagttc tctgtgctctgccgggacctatacgccctctacccactgctcatccgctatgtggacaac aacagggcacactggctcacagagcccaaccccagtgctgaggagttattccggatggtg ggcgagatcttcatctattggtccaagtcccacaactttaagcgtgaggagcagaacttc gtggtccagaatgagatcaacaacatgtccttcctgacggctgacagcaagagcaagatg gccaaggcgggagatgtacagtcgggcggctcggaccaggaacgcaccaagaagaagcgt cggggtgaccggtactcagtacagacatcgctgatcgtggccacactgaaaaagatgctg cccatcggcctgaacatgtgcgcacccactgaccaggacctcatcgcgctggccaagacc cgctacgccctgaaagacaccgacgaggaggtccgggagtttctgcagaacaaccttcac ctgcaaggaaaggtcgaaggttccccatccctgcgctggcagatggcgctctaccggggc ctgcctggccgcgaggagggcactgacgacccggagaaaatcgtccgcagggtccaggag gtgtcagcggtgctctaccacctggaacagaccgagcacccttacaaatccaagaaggcc gtgtggcacaagctgctatccaagcagcgccggcgagccgtggtggcctgcttccggatg acgccactgtacaacttgcccacacaccgagcttgtaacatgttcctggagagttacaag gctgcctggatcctgaccgaggaccacagtttcgaggatcgcatgatagatgatctttca aaagctggggagcaggaggaagaggaggaggaagtggaggagaagaagccagaccccctg caccagctggtcctgcactttagccgaacagccttaacggaaaagagcaaactggatgag gattacctgtacatggcctacgccgacatcatggccaagagctgccacttggaggaggga ggggagaacggcgaagctgaagaagaggaggttgaggtctcctttgaggagaaagagatg gagaagcagaggctcctgtaccagcagtcgcggctgcacaaccgcggggctgccgagatg gtgctgcagatgatcagtgcctgcaaaggagagacaggtgccatggtgtcctccactctg aagctgggtatctccatcctcaatggaggcaacgccgaggtgcagcagaaaatgctggat tatctgaaggacaagaaggaagttggcttcttccagagcatccaggcgctgatgcagacc tgcagtgtcctggatctcaatgccttcgagagacagaacaaggcagaggggctgggcatg gtgaatgaagatggaactgtcatcaatcgccagaacggagagaaggtcatggccgatgat gaattcacacaagacctgttccgatttctgcagttgctctgcgaaggacataataatgat ttccaaaactacctgcggacacagactgggaacaccaccacaatcaacattatcatctgc acagtggactacctcctgcgactgcaggagtccatcagcgacttctactggtactactcg ggcaaggacgtcattgaggagcagggcaagagaaacttctccaaggccatgtctgtggcc aagcaggtgttcaacagcctcaccgagtatatccagggcccctgcaccggaaaccagcag agcctggcacacagccgcctctgggacgccgtggtgggattcttgcacgtgtttgcccac atgatgatgaagctggctcaggactcgagccagatcgagctgctgaaggaactgctggac ctccagaaagacatggtggtgatgctgctgtcactactggaagggaatgtggtaaacggc atgatcgcgcggcagatggtggacatgctggttgagtcgtcgtccaacgtggagatgatc ctcaagttctttgacatgttcctgaaactcaaggacattgtgggctccgaggcgttccag gactacgtcacagatccccgaggcctcatctccaagaaggacttccagaaggccatggac agccaaaagcaattcaccggaccagaaatccagtttctgctttcctgctccgaagccgat gagaatgagatgatcaactttgaggagttcgccaaccgcttccaggagccggcccgcgac ataggcttcaacgtggctgtgttgctgaccaacctgtcggagcatgtgccgcacgacccg cgcctgcgcaacttcctggagctagctgagagcatcctggagtacttccggccctacctg ggccgcatcgagatcatgggctcctcgcgccgcatcgagcgtatctacttcgagatctct gagaccaaccgggcccagtgggagatgccgcaggtgaaggaatccaagcgccagttcatc ttcgacgtggtcaacgagggcggagaggcggaaaagatggaactcttcgtgagcttctgc gaggacaccatcttcgagatgcagatcgccgcacagatctcggagcccgagggcgagcct gaagctgacgaggacgagggcgccgctgaggagggcgccgaggagggagcggcgggcccc gagggagcggcgggcacggcggcggcgggcgccacgacgcggctgtcggcgctcgcggcc cgggcgctgcgcggcctcagctaccgcagcctgcggcggcgcgtgcggagactgcggcgg ctgacggcgcgggaggcggctaccgccctggccgcactgctctgggccgtggtggcgcgc gcgggcgcggcgggcgcaggggctgcggcgggggcactgcacctgctctgggggtcgctc ttcggcggtggtctggtggagggtgccaagaaagtgacagtgaccgagctgctggccggc atgcccgaccccacgggggatgaggtgcacggcgagcagccagcgggccccggcggcgac gcagacggcgcgggcgagggcgaaggcgagggcgacacggcggagggtgccggcgacgag gaggtggcaggtcacgaggctgggccaggcggcgctgagggggcagtagctgtgaccgaa gggggccccttccggcccgagggccctggcggcctcggggacatgggtgacaccacacca gtggagccacccacgcccgagggctcgcccatcctcaagaggaagctgggggtggatgga gaggaggaggaggagctgattccagaacccgaaccagagccagagccagagccagagaag gcagatgaggagaatggagagaaggaagaagtcccagagacacccccagaaccccccaag aaagcacctcctccacctcccgcaaagaaggaagaagccagaggcgtcggcatggaattc tggggagagctggaagtgcagagggtcaagttcttgaactacctctcccggaacttctac acactgcgcttcctcgccctctttttggcattcgccatcaacttcatcctgctattttat aaggtctcagattccccgccaggggaggatgactttgagggctccgcagctggggacctg tccggggcagggtctggaggtggctccggctggggctcggggcctggcgaggaggccgag ggcgacgaggatgacaacatggtctactacttcctggaggagagcacgggctacatggag cccgccctgtggtgcctgagcctgctgcacacgctggtggctttcctttgcattatcggt tacaactgcctcaaggtacccctggtgatttttaaacgggagaaggagctggcccggaag ctggagtttgatggcctctacatcacagaacagcccgaggacgatgacgtgaagggccag tgggaccggctggtactcaacacaccgtctttccccagcaactactgggacaagtttgtc aagcggaaggtcctggacaaacacggggacatcttcgggcgggagcgcatcgccgagcta ctgggcatggacctggcctcactggagatcacagcccacaatgaccgcaagcccgacccc cctccgggcctactgacctggctcatgtccattgatgtcaagtatcagatctggaagttt ggggtgatcttcaccgacaattcattcctgtatctggggtggtatatggtgatgtccctc ctgggccactacaacaacttcttcttcgctgcccacctgctggacatcgccatgggggtc aagacgctgcgcaccattctctcctcagtcacccacaatgggaaacagctggtgatgacc gtgggcctcctggcagtggtggtctacctgtacacggtggtggccttcaacttcttccgt aagttctacaacaagagtgaggacgaggatgaccctgacatgaagtgcgatgacatgatg acgtgttacttgtttcacatgtatgtgggcgtgcgagccggtggaggcatcggggatgag attgaggacccagcaggcgatgaatatgagctctaccgcgtggtcttcgacatcactttc ttcttcttcgtcatcgtcatcctgctggccatcatccagggtctcattattgatgctttt ggggaactccgagaccagcaggagcaagtaaaggaagatatggagaccaagtgcttcatc tgtggaattggcagcgattactttgacaccacgccgcacggctttgagacacacacgctg gaggagcacaacctggccaattatatgtttttcctgatgtatctgatcaacaaggacgag actgaacacactggtcaggagtcttacgtctggaagatgtatcaggagaggtgttgggac ttcttcccagccggtgactgtttccgcaagcaatatgaggaccagctgggctga

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