KEGG   Ochotona princeps (American pika): 105942099
Entry
105942099         CDS       T07609                                 
Name
(RefSeq) LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04015  Rap1 signaling pathway
opi04022  cGMP-PKG signaling pathway
opi04024  cAMP signaling pathway
opi04066  HIF-1 signaling pathway
opi04068  FoxO signaling pathway
opi04071  Sphingolipid signaling pathway
opi04072  Phospholipase D signaling pathway
opi04140  Autophagy - animal
opi04148  Efferocytosis
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04210  Apoptosis
opi04218  Cellular senescence
opi04270  Vascular smooth muscle contraction
opi04370  VEGF signaling pathway
opi04371  Apelin signaling pathway
opi04540  Gap junction
opi04550  Signaling pathways regulating pluripotency of stem cells
opi04613  Neutrophil extracellular trap formation
opi04620  Toll-like receptor signaling pathway
opi04650  Natural killer cell mediated cytotoxicity
opi04660  T cell receptor signaling pathway
opi04662  B cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04720  Long-term potentiation
opi04722  Neurotrophin signaling pathway
opi04730  Long-term depression
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04912  GnRH signaling pathway
opi04915  Estrogen signaling pathway
opi04916  Melanogenesis
opi04917  Prolactin signaling pathway
opi04919  Thyroid hormone signaling pathway
opi04921  Oxytocin signaling pathway
opi04926  Relaxin signaling pathway
opi04929  GnRH secretion
opi04934  Cushing syndrome
opi04935  Growth hormone synthesis, secretion and action
opi05010  Alzheimer disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05132  Salmonella infection
opi05135  Yersinia infection
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05163  Human cytomegalovirus infection
opi05164  Influenza A
opi05165  Human papillomavirus infection
opi05166  Human T-cell leukemia virus 1 infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05170  Human immunodeficiency virus 1 infection
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05206  MicroRNAs in cancer
opi05207  Chemical carcinogenesis - receptor activation
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05216  Thyroid cancer
opi05218  Melanoma
opi05219  Bladder cancer
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
opi05230  Central carbon metabolism in cancer
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105942099
   04012 ErbB signaling pathway
    105942099
   04014 Ras signaling pathway
    105942099
   04015 Rap1 signaling pathway
    105942099
   04370 VEGF signaling pathway
    105942099
   04371 Apelin signaling pathway
    105942099
   04066 HIF-1 signaling pathway
    105942099
   04068 FoxO signaling pathway
    105942099
   04072 Phospholipase D signaling pathway
    105942099
   04071 Sphingolipid signaling pathway
    105942099
   04024 cAMP signaling pathway
    105942099
   04022 cGMP-PKG signaling pathway
    105942099
   04151 PI3K-Akt signaling pathway
    105942099
   04150 mTOR signaling pathway
    105942099
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105942099
   04148 Efferocytosis
    105942099
  09143 Cell growth and death
   04210 Apoptosis
    105942099
   04218 Cellular senescence
    105942099
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105942099
   04550 Signaling pathways regulating pluripotency of stem cells
    105942099
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105942099
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105942099
   04620 Toll-like receptor signaling pathway
    105942099
   04650 Natural killer cell mediated cytotoxicity
    105942099
   04660 T cell receptor signaling pathway
    105942099
   04662 B cell receptor signaling pathway
    105942099
   04664 Fc epsilon RI signaling pathway
    105942099
  09152 Endocrine system
   04910 Insulin signaling pathway
    105942099
   04929 GnRH secretion
    105942099
   04912 GnRH signaling pathway
    105942099
   04915 Estrogen signaling pathway
    105942099
   04917 Prolactin signaling pathway
    105942099
   04921 Oxytocin signaling pathway
    105942099
   04926 Relaxin signaling pathway
    105942099
   04935 Growth hormone synthesis, secretion and action
    105942099
   04919 Thyroid hormone signaling pathway
    105942099
   04916 Melanogenesis
    105942099
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105942099
  09156 Nervous system
   04720 Long-term potentiation
    105942099
   04730 Long-term depression
    105942099
   04722 Neurotrophin signaling pathway
    105942099
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105942099
   05206 MicroRNAs in cancer
    105942099
   05205 Proteoglycans in cancer
    105942099
   05207 Chemical carcinogenesis - receptor activation
    105942099
   05208 Chemical carcinogenesis - reactive oxygen species
    105942099
   05230 Central carbon metabolism in cancer
    105942099
   05231 Choline metabolism in cancer
    105942099
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105942099
  09162 Cancer: specific types
   05210 Colorectal cancer
    105942099
   05225 Hepatocellular carcinoma
    105942099
   05226 Gastric cancer
    105942099
   05214 Glioma
    105942099
   05216 Thyroid cancer
    105942099
   05221 Acute myeloid leukemia
    105942099
   05220 Chronic myeloid leukemia
    105942099
   05218 Melanoma
    105942099
   05211 Renal cell carcinoma
    105942099
   05219 Bladder cancer
    105942099
   05215 Prostate cancer
    105942099
   05213 Endometrial cancer
    105942099
   05224 Breast cancer
    105942099
   05223 Non-small cell lung cancer
    105942099
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105942099
   05170 Human immunodeficiency virus 1 infection
    105942099
   05161 Hepatitis B
    105942099
   05160 Hepatitis C
    105942099
   05164 Influenza A
    105942099
   05163 Human cytomegalovirus infection
    105942099
   05167 Kaposi sarcoma-associated herpesvirus infection
    105942099
   05165 Human papillomavirus infection
    105942099
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105942099
   05135 Yersinia infection
    105942099
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105942099
   05022 Pathways of neurodegeneration - multiple diseases
    105942099
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105942099
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105942099
   01522 Endocrine resistance
    105942099
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    105942099
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     105942099
Protein kinases [BR:opi01001]
 Serine/threonine kinases: STE group
  STE7 family
   105942099
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like
Other DBs
NCBI-GeneID: 105942099
NCBI-ProteinID: XP_036353700
LinkDB
Position
X
AA seq 398 aa
MLARRKLVLPALTINPTIAEGPSPXGTSEANLVDLHKKLEELELDEQQRRRLEAFLTQKA
KAGELKEDDFERISELGAGNGGVVTKVRHRPSGLIMARKLIHLEIKPATRNQISRELQVL
HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAQRIPEEILGKVSIAVLRGLA
YLREKDQIMHREVKPSNILVNSRGQIKLFDFGVSGQLIDSMANSFVGTRSYMSPERLQGT
HYSVQSDIWSMGLSLVELAIGRYPVPPLDAKELXATFGWPMVDAADTEPHSTSPRPRPPG
RPVSGHGVDSRPAMAIFELLDYMVNXPPPKLPSSVFTADFQEFVNKCLIKNPAEQADLKM
LMNHTFIKRSEVEEVDFAGWLCETLRLKQPSTPTHLAM
NT seq 1197 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagctggtcctgccggcactcaccatcaatcccaccatcgctgag
ggtccctccccgnacggcacatccgaagcgaacctggtggacctgcacaagaagcttgag
gagcttgagttagacgagcagcagaggcggcgcctggaggccttcctcacccagaaggcc
aaggccggcgagctcaaggaggatgactttgaaaggatctcagagctgggggccggcaat
ggcggcgtggtcaccaaggtgcggcaccggccctcggggcttatcatggccaggaagctg
atccacctagagatcaagccggccacccggaaccagatcagccgtgagctgcaggtgctg
catgagtgcaactcgccctacatcgtgggcttctacggggccttctacagtgacggcgag
atcagtatatgcatggagcacatggacggcggctccctggaccaggtgctgaaggaggcc
cagaggattccagaagagatcctgggcaaagtcagcattgcggtcctccggggtctggcg
tatctccgagagaaagaccaaatcatgcatcgagaagtaaagccctccaacattctggtc
aactcccggggccagatcaagctgttcgacttcggcgtcagcgggcagctcatcgactcc
atggctaactccttcgtgggcacgcgctcctacatgtctccggagcggctgcagggcacc
cactactcggtgcagtcggatatctggagcatgggcctgtccctggtggagctggccatc
ggcaggtatcccgtgcccccactggacgccaaggagctctaggccacgttcggctggccc
atggtggacgcggcggacacagagcctcacagcacctcacctcgcccacggcccccagga
cgccccgtcagcggtcacggggtggacagccggccagccatggccatcttcgaactactg
gactacatggtgaattagccacctcccaaactgcccagcagcgtgttcaccgccgacttc
caggagtttgtaaataaatgcctcatcaagaacccggcagaacaagcagacctcaagatg
ctcatgaaccacaccttcatcaagcggtccgaggtagaggaagtggactttgctggctgg
ctttgtgagaccctgcggctgaagcagcccagtacgcccacgcacttggccatgtga

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