KEGG   PATHWAY: acti02010
Entry
acti02010                   Pathway                                
Name
ABC transporters - Actinoalloteichus sp. GBA129-24
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
acti02010  ABC transporters
acti02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Actinoalloteichus sp. GBA129-24 [GN:acti]
Gene
UA75_25130  ABC transporter, substrate-binding protein, aliphatic sulfonates family [KO:K15553]
UA75_25140  ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [KO:K15554]
UA75_25135  ABC transporter [KO:K15555] [EC:7.6.2.14]
UA75_07980  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
UA75_07985  molybdate ABC transporter, permease protein [KO:K02018]
UA75_07990  ABC-type spermidine/putrescine transport system, ATPase component [KO:K02017] [EC:7.3.2.5]
UA75_27490  ABC-type Fe3+ transport system, periplasmic component [KO:K02012]
UA75_27495  ABC-type Fe3+ transport system, permease component [KO:K02011]
UA75_27500  ABC-type spermidine/putrescine transport system, ATPase component [KO:K02010] [EC:7.2.2.7]
UA75_04375  ABC transporter periplasmic binding protein, thiB subfamily [KO:K02064]
UA75_04380  ABC-type Fe3+ transport system, permease component [KO:K02063]
UA75_04385  ABC-type spermidine/putrescine transport system, ATPase component [KO:K02062] [EC:7.6.2.15]
UA75_08960  spermidine/putrescine-binding periplasmic protein [KO:K11069]
UA75_08970  ABC-type spermidine/putrescine transport system, permease component II [KO:K11070]
UA75_08965  ABC-type spermidine/putrescine transport system, permease component I [KO:K11071]
UA75_08955  ABC-type spermidine/putrescine transport system, ATPase component [KO:K11072] [EC:7.6.2.11]
UA75_00265  glycine betaine/carnitine/choline binding protein [KO:K05845]
UA75_26935  glycine/betaine ABC transporter substrate-binding protein [KO:K05845]
UA75_00250  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
UA75_00260  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
UA75_26945  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
UA75_26950  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
UA75_00255  ABC-type proline/glycine betaine transport system, ATPase component [KO:K05847] [EC:7.6.2.9]
UA75_26955  ABC-type proline/glycine betaine transport system, ATPase component [KO:K05847] [EC:7.6.2.9]
UA75_04750  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112] [EC:7.5.2.-]
UA75_20525  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112] [EC:7.5.2.-]
UA75_01775  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112] [EC:7.5.2.-]
UA75_24060  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112] [EC:7.5.2.-]
UA75_01790  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K15770]
UA75_01785  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K15771]
UA75_01780  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K15772]
UA75_23420  ABC-type sugar transport system, periplasmic component [KO:K10227]
UA75_23425  permease component of ABC-type sugar transporter [KO:K10228]
UA75_23430  ABC-type sugar transport system, permease component [KO:K10229]
UA75_08170  ABC-type sugar transport system, periplasmic component [KO:K10232]
UA75_08175  ABC-type sugar transport system, permease component [KO:K10233 K10234]
UA75_07330  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K17318]
UA75_07335  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K17319]
UA75_07340  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K17320]
UA75_04735  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K10236]
UA75_04740  permease component of ABC-type sugar transporter [KO:K10237]
UA75_04745  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K10238]
UA75_06740  cellobiose-binding protein [KO:K10240]
UA75_21565  cellobiose-binding protein [KO:K10240]
UA75_06745  cellobiose ABC transporter membrane protein [KO:K10241]
UA75_21560  cellobiose ABC transporter membrane protein [KO:K10241]
UA75_06750  cellobiose ABC transporter membrane protein [KO:K10242]
UA75_21555  cellobiose ABC transporter membrane protein [KO:K10242]
UA75_01980  ABC-type sugar transport system, periplasmic component [KO:K17329]
UA75_01985  permease component of ABC-type sugar transporter [KO:K17330]
UA75_01990  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K17331]
UA75_22750  ABC-type sugar transport system, periplasmic component [KO:K17234]
UA75_22755  permease component of ABC-type sugar transporter [KO:K17235]
UA75_22760  ABC-type sugar transport system, permease component [KO:K17236]
UA75_19360  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K17326]
UA75_19355  permease component of ABC-type sugar transporter [KO:K17327]
UA75_19350  ABC-type sugar transport system, permease component [KO:K17328]
UA75_13390  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K23545]
UA75_13400  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K23546]
UA75_13395  ABC-type sugar transport system, ATPase component [KO:K23547]
UA75_28035  basic membrane lipoprotein [KO:K07335]
UA75_13720  lipoprotein [KO:K07335]
UA75_13710  ABC-type uncharacterized transport system, permease component [KO:K23535]
UA75_28025  nucleoside ABC transporter membrane protein [KO:K23535]
UA75_13705  hypothetical protein [KO:K23536]
UA75_28020  nucleoside ABC transporter membrane protein [KO:K23536]
UA75_13715  ATPase component of uncharacterized ABC-type transporter [KO:K23537]
UA75_28030  ATPase component of uncharacterized ABC-type transporter [KO:K23537]
UA75_30690  ABC-type sugar transport system, periplasmic component [KO:K10439]
UA75_01005  ABC-type sugar transport system, periplasmic component [KO:K10439]
UA75_18735  ABC-type sugar transport system, periplasmic component [KO:K10439]
UA75_21200  ABC-type sugar transport system, periplasmic component [KO:K10439]
UA75_27685  ABC-type sugar transport system, periplasmic component [KO:K10439]
UA75_21205  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10440]
UA75_27690  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10440]
UA75_30695  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10440]
UA75_21210  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10440]
UA75_00995  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10440]
UA75_27695  ABC-type sugar transport system, ATPase component [KO:K10441] [EC:7.5.2.7]
UA75_01000  ABC-type sugar transport system, ATPase component [KO:K10441] [EC:7.5.2.7]
UA75_30700  ABC-type sugar transport system, ATPase component [KO:K10441] [EC:7.5.2.7]
UA75_21215  ABC-type sugar transport system, ATPase component [KO:K10441] [EC:7.5.2.7]
UA75_30680  ABC-type ribose transport system, auxiliary component [KO:K06726] [EC:5.4.99.62]
UA75_18815  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K23508]
UA75_18805  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K23509]
UA75_18800  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K23509]
UA75_18810  ABC-type sugar transport system, ATPase component [KO:K10820] [EC:7.5.2.9]
UA75_08380  ABC-type xylose transport system, periplasmic component [KO:K10543]
UA75_08390  ABC-type xylose transport system, permease component [KO:K10544]
UA75_08385  ABC transporter [KO:K10545] [EC:7.5.2.10]
UA75_27315  rhamnose ABC transporter, rhamnose-binding protein [KO:K10559]
UA75_27325  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10560]
UA75_27320  permease component of ribose/xylose/arabinose/galactoside ABC-type transporters [KO:K10561]
UA75_27330  ABC-type sugar transport system, ATPase component [KO:K10562] [EC:7.5.2.-]
UA75_29640  phosphate ABC transporter, phosphate-binding protein [KO:K02040]
UA75_29635  phosphate ABC transporter membrane protein 1, PhoT family [KO:K02037]
UA75_29630  phosphate ABC transporter membrane protein 2, PhoT family [KO:K02038]
UA75_29625  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
UA75_08555  ABC transporter substrate-binding protein [KO:K10005]
UA75_08550  polar amino acid ABC transporter, inner membrane subunit [KO:K10006]
UA75_08545  amino acid ABC transporter membrane protein [KO:K10007]
UA75_08560  ABC-type polar amino acid transport system, ATPase component [KO:K10008] [EC:7.4.2.1]
UA75_10690  ABC-type branched-chain amino acid transport system, periplasmic component [KO:K01999]
UA75_13595  amino acid/amide ABC transporter membrane protein 1, HAAT family [KO:K01997]
UA75_10695  branched-chain amino acid ABC-type transport system, permease component [KO:K01997]
UA75_13600  ABC-type branched-chain amino acid transport system, permease component [KO:K01998]
UA75_10700  ABC-type branched-chain amino acid transport system, permease component [KO:K01998]
UA75_13590  amino acid/amide ABC transporter ATP-binding protein 1, HAAT family [KO:K01995]
UA75_10705  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01995]
UA75_13585  amino acid/amide ABC transporter ATP-binding protein 2, HAAT family [KO:K01996]
UA75_10710  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01996]
UA75_03660  ABC-type metal ion transport system, periplasmic component/surface antigen [KO:K02073]
UA75_03655  ABC-type metal ion transport system, permease component [KO:K02072]
UA75_03650  ABC-type metal ion transport system, ATPase component [KO:K02071]
UA75_04475  ABC-type dipeptide transport system, periplasmic component [KO:K13889]
UA75_04480  ABC-type dipeptide/oligopeptide/nickel transport system, permease component [KO:K13890]
UA75_04485  ABC-type dipeptide/oligopeptide/nickel transport system, permease component [KO:K13891]
UA75_04490  oligopeptide/dipeptide ABC transporter, ATP-binding protein [KO:K13892]
UA75_13300  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K25286]
UA75_15025  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K25286]
UA75_20840  ABC-type Fe3+-citrate transport system, periplasmic component [KO:K25286]
UA75_19865  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K25286]
UA75_13305  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
UA75_15020  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
UA75_19880  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
UA75_20835  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
UA75_13310  ABC-type enterobactin transport system, permease component [KO:K23187]
UA75_15015  ABC-type enterobactin transport system, permease component [KO:K23187]
UA75_19875  ABC-type enterobactin transport system, permease component [KO:K23187]
UA75_20830  ABC-type enterobactin transport system, permease component [KO:K23187]
UA75_13315  ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component [KO:K23188] [EC:7.2.2.17 7.2.2.-]
UA75_15010  ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component [KO:K23188] [EC:7.2.2.17 7.2.2.-]
UA75_10545  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K23227]
UA75_10540  ABC-type Fe3+-siderophore transport system, permease component [KO:K23228]
UA75_10550  ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component [KO:K10829] [EC:7.2.2.16]
UA75_11355  ABC-type metal ion transport system, periplasmic component/surface adhesin [KO:K11707]
UA75_11365  ABC-type Mn2+/Zn2+ transport system, permease component [KO:K11708]
UA75_11370  ABC-type Mn2+/Zn2+ transport system, permease component [KO:K11709]
UA75_11360  ATPase component of Mn/Zn ABC-type transporter [KO:K11710] [EC:7.2.2.5]
UA75_06170  hypothetical protein [KO:K03523]
UA75_13155  ABC-type cobalt transport system, permease component CbiQ [KO:K16785]
UA75_00705  ABC-type polysaccharide/polyol phosphate export system, permease component [KO:K09690]
UA75_00700  ABC-type polysaccharide/polyol phosphate transport system, ATPase component [KO:K09691] [EC:7.5.2.14]
UA75_08130  ABC-type multidrug transport system, permease component [KO:K09694]
UA75_08135  ABC-type multidrug transport system, permease component [KO:K09694]
UA75_08125  ABC-type multidrug transport system, ATPase component [KO:K09695]
UA75_18600  ABC-2 family transporter protein [KO:K20460]
UA75_18595  hypothetical protein [KO:K20461]
UA75_18605  ABC-type multidrug transport system, ATPase component [KO:K20459]
UA75_17175  hypothetical protein [KO:K16905]
UA75_17180  hypothetical protein [KO:K16906]
UA75_17185  ABC-type multidrug transport system, ATPase component [KO:K16907] [EC:7.6.2.-]
UA75_05045  cell division protein [KO:K09811]
UA75_05040  cell division ATP-binding protein FtsE [KO:K09812]
UA75_17125  ABC-type multidrug transport system, ATPase and permease component [KO:K14698] [EC:7.-.-.-]
UA75_17120  ABC-type multidrug transport system, ATPase and permease component [KO:K14699] [EC:7.-.-.-]
UA75_10335  ABC-type multidrug transport system, ATPase and permease component [KO:K18887]
UA75_10330  ABC-type multidrug transport system, ATPase and permease component [KO:K18888]
UA75_23810  cysteine ABC transporter permease/ATP-binding protein CydC [KO:K16012]
UA75_23805  ABC transporter [KO:K16013]
UA75_00560  hypothetical protein [KO:K16014]
UA75_06570  ATPase component of ABC transporters with duplicated ATPase domain [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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