KEGG   PATHWAY: acx02010
Entry
acx02010                    Pathway                                
Name
ABC transporters - Azotobacter chroococcum
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
acx02010  ABC transporters
acx02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Azotobacter chroococcum [GN:acx]
Gene
Achr_25560  cysP; Sulfate ABC transporter-binding component-CysP-like protein [KO:K02048]
Achr_16900  sulfate ABC transporter, periplasmic sulfate-binding protein [KO:K23163]
Achr_16890  cysT; Sulfate ABC transporter, permease protein CysT [KO:K02046]
Achr_16880  cysW; Sulfate ABC transporter, permease protein CysW [KO:K02047]
Achr_16870  cysA; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02045] [EC:7.3.2.3]
Achr_39290  ABC type tungstate transporter, permease component [KO:K05772]
Achr_f310  ABC transporter, aliphatic sulfonate binding protein [KO:K15553]
Achr_16940  ABC transporter, periplasmic substrate-binding protein, aliphatic sulfonates family [KO:K15553]
Achr_17140  ABC nitrate/sulfonate/bicarbonate family transporter, periplasmic ligand binding protein [KO:K15553]
Achr_25530  ssuA; ABC transporter periplasmic aliphatic sulfonate-binding protein [KO:K15553]
Achr_17130  ABC nitrate/sulfonate/bicarbonate family transporter, periplasmic ligand binding protein [KO:K15553]
Achr_17370  ABC transporter, periplasmic substrate-binding protein [KO:K15553]
Achr_17230  NitT/TauT family transport system substrate-binding protein [KO:K15553]
Achr_17330  ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [KO:K15553]
Achr_25510  ssuC; sulfonate ABC transporter [KO:K15554]
Achr_17220  ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [KO:K15554]
Achr_17350  ABC transporter, permease protein [KO:K15554]
Achr_25500  ssuB; Aliphatic sulfonates import ATP-binding protein SsuB 1 [KO:K15555] [EC:7.6.2.14]
Achr_17340  ABC transporter, ATP-binding protein [KO:K15555] [EC:7.6.2.14]
Achr_17210  ABC transporter ATP binding protein [KO:K15555] [EC:7.6.2.14]
Achr_39250  modA1; molybdenum transporter, periplasmic molybdate-binding protein [KO:K02020]
Achr_39320  modA3; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
Achr_39240  modB1; Mo transporter membrane protein, ModB1 [KO:K02018]
Achr_39310  Molybdate ABC transporter, inner membrane subunit [KO:K02018]
Achr_1450  Molybdenum import ATP-binding protein ModC 2 [KO:K02017] [EC:7.3.2.5]
Achr_39230  modC1; Mo transporter, inner membrane ATP-binding component, ModC1 [KO:K02017] [EC:7.3.2.5]
Achr_39280  ABC transporter ATP binding component [KO:K02017] [EC:7.3.2.5]
Achr_36640  Iron ABC transporter substrate-binding protein [KO:K02012]
Achr_36630  Ferric iron ABC transporter, FeT family, permease protein [KO:K02011]
Achr_28780  ABC transporter, ATP binding component [KO:K02010] [EC:7.2.2.7]
Achr_3380  potF; Polyamine transporter periplasmic protein PotF [KO:K11073]
Achr_3410  potI; Spermidine/putrescine ABC transporter permease [KO:K11074]
Achr_3400  potH; Polyamine transport protein PotH [KO:K11075]
Achr_3390  potG; polyamine ABC transporter ATP-binding subunit, PotG subunit [KO:K11076] [EC:7.6.2.16]
Achr_f410  Substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002]
Achr_29800  Organic solvent tolerance ABC efflux transporter, auxiliary component [KO:K07323]
Achr_29810  Organic solvent tolerance ABC efflux transporter, substrate binding protein [KO:K02067]
Achr_36320  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
Achr_29820  Organic solvent tolerance ABC efflux transporter, permease component [KO:K02066]
Achr_36300  ABC transporter permease [KO:K02066]
Achr_29790  STAS family protein [KO:K07122]
Achr_29830  organic solvent tolerance ABC efflux transporter, ATP binding component [KO:K02065]
Achr_36310  ABC transporter, ATP binding component [KO:K02065]
Achr_9860  Periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Achr_12220  Periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Achr_12510  Periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Achr_37810  periplasmic sugar binding protein [KO:K10439]
Achr_3010  Sugar ABC transporter periplasmic sugar-binding protein [KO:K10439]
Achr_27480  periplasmic sugar-binding protein [KO:K10439]
Achr_3510  pstS; Phosphate ABC transporter periplasmic phosphate-binding protein, PstS [KO:K02040]
Achr_20730  Phosphate ABC transporter substrate-binding protein, PhoT family [KO:K02040]
Achr_18880  ABC-type phosphate transport system, periplasmic component [KO:K02040]
Achr_3520  pstC; Phosphate ABC-transporter, permease protein PstC [KO:K02037]
Achr_20720  phosphate ABC transporter membrane protein 1, PhoT family [KO:K02037]
Achr_3530  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
Achr_20710  phosphate ABC transporter membrane protein 2, PhoT family [KO:K02038]
Achr_3540  pstB; Phosphate import ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
Achr_17570  Phosphonate ABC transporter, substrate-binding protein [KO:K02044]
Achr_2470  Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding family protein [KO:K02044]
Achr_17540  Phosphonate ABC transporter, permease protein PhnE [KO:K02042]
Achr_17550  Phosphonate ABC transporter, permease PhnE [KO:K02042]
Achr_2460  Phosphite transport system permease protein ptxC [KO:K02042]
Achr_17560  Phosphonates import ATP-binding protein PhnC 2 [KO:K02041] [EC:7.3.2.2]
Achr_2480  P-loop containing nucleoside triphosphate hydrolase [KO:K02041] [EC:7.3.2.2]
Achr_33900  amino acid ABC transporter, perplasmic binding protein [KO:K10001]
Achr_33920  Amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10002]
Achr_33910  Amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10003]
Achr_33930  amino acid ABC transporter, ATP binding component [KO:K10004] [EC:7.4.2.1]
Achr_17520  livK; Branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
Achr_21450  Amino acid ABC transporter substrate-binding protein [KO:K01999]
Achr_17510  livH; high affinity branched chain amino acid ABC transporter, permease component [KO:K01997]
Achr_21440  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Achr_17500  livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Achr_21430  Branched-chain amino acid ABC transporter permease [KO:K01998]
Achr_21420  High affinity branched-chain amino acid ABC transporter, ATP-binding protein LivG [KO:K01995]
Achr_17490  livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995]
Achr_21410  ABC transporter, ATP-binding protein [KO:K01996]
Achr_17480  high affinity branched chain amino acid ABC transporter, ATP binding component [KO:K01996]
Achr_17020  ABC-type metal ion transport system, periplasmic component/surface antigen [KO:K02073]
Achr_16990  Metal ABC transporter permease [KO:K02072]
Achr_17000  ABC transporter, ATP-binding component [KO:K02071]
Achr_30130  Dipeptide ABC transporter, periplasmic substrate-binding component [KO:K12368]
Achr_37430  extracellular solute-binding protein [KO:K12368]
Achr_30140  Dipeptide ABC transporter, inner membrane permease component [KO:K12369]
Achr_30150  Dipeptide ABC transporter, inner membrane permease component [KO:K12370]
Achr_30160  Oligopeptide/dipeptide ABC transporter, ATP-binding component [KO:K12371]
Achr_30170  Oligopeptide/dipeptide ABC transporter, ATP-binding component [KO:K12372]
Achr_18210  ABC-type oligopeptide transport system, periplasmic component [KO:K13893]
Achr_18220  ABC transporter, periplasmic substrate-binding protein [KO:K13893]
Achr_18200  Oligopeptide ABC transporter, inner membrane permease component [KO:K13894]
Achr_18190  Oligopeptide ABC transporter, inner membrane permease component [KO:K13895]
Achr_18180  ABC transporter, ATP binding component [KO:K13896]
Achr_38800  fhuC; iron(III)-siderophore ABC transporter ATP-binding protein [KO:K10829] [EC:7.2.2.16]
Achr_34430  Periplasmic binding protein [KO:K06858]
Achr_550  znuA; zinc ABC transporter substrate-binding protein [KO:K09815]
Achr_520  znuB; Zinc ABC transporter, inner membrane permease protein ZnuB [KO:K09816]
Achr_530  znuC; zinc ABC transporter, ATP binding protein [KO:K09817] [EC:7.2.2.20]
Achr_26810  Lipopolysaccharide ABC export system, permease p [KO:K09690]
Achr_26800  Lipopolysaccharide ABC export system, ATP-binding protein [KO:K09691] [EC:7.5.2.14]
Achr_28130  lolE; Lipoprotein releasing system, permease protein [KO:K09808]
Achr_28150  lolC; Lipoprotein releasing system, transmembrane protein [KO:K09808]
Achr_3060  Lipoprotein release ABC transporter permease [KO:K09808]
Achr_28140  lolD; lipoprotein-releasing ABC transporter [KO:K09810] [EC:7.6.2.-]
Achr_3070  P-loop containing nucleoside triphosphate hydrolase [KO:K09810] [EC:7.6.2.-]
Achr_25400  ccmD; cytochrome c-type biogenesis protein CcmD [KO:K02196]
Achr_25410  ccmC; cytochrome c-type biogenesis protein [KO:K02195]
Achr_25420  ccmB; Cytochrome c-type biogenesis protein CcmB [KO:K02194]
Achr_25430  ccmA; cytochrome c biogenesis protein CcmA [KO:K02193] [EC:7.6.2.5]
Achr_30710  lptF; Permease YjgP/YjgQ family [KO:K07091]
Achr_7300  permease YjgP/YjgQ family [KO:K07091]
Achr_30700  lptG; Permease YjgP/YjgQ family [KO:K11720]
Achr_7290  permease YjgP/YjgQ family [KO:K11720]
Achr_29880  lptB; LPS transport protein LptB [KO:K06861] [EC:7.5.2.5]
Achr_37450  ftsX; Cell division protein FtsX [KO:K09811]
Achr_37460  ftsE; Cell-division ATP-binding protein FtsE [KO:K09812]
Achr_7040  msbA; Lipid A export ATP-binding/permease protein MsbA [KO:K11085] [EC:7.5.2.6]
Achr_15710  Type I secretion system ABC transporter, HlyB family [KO:K11004]
Achr_15040  ABC transporter, composite transmembrane permease and ATP binding components [KO:K24821]
Achr_26850  eexD; Type I secretion system ATPase [KO:K12536]
Achr_f2140  cyclic peptide transporter [KO:K06159]
Achr_38820  pvdE; pyoverdine synthetase E, pdvE [KO:K06160]
Achr_34050  ABC-type transport system (Fused ATP-binding and permease components) [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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