PATHWAY: babc02010 Help
Entry
Name
ABC transporters - Brucella abortus NCTC 10505
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Brucella abortus NCTC 10505 [GN:
babc ]
Gene
DO78_1228 sulfate ABC transporter, sulfate-binding family protein [KO:K02048 ]
DO78_36 sulfate ABC transporter, sulfate-binding family protein [KO:K23163 ]
DO78_37 cysT; sulfate ABC transporter, permease protein CysT [KO:K02046 ]
DO78_38 cysW; sulfate ABC transporter, permease protein CysW [KO:K02047 ]
DO78_3012 binding--dependent transport system inner membrane component family protein [KO:K15554 ]
DO78_2190 binding--dependent transport system inner membrane component family protein [KO:K15554 ]
DO78_135 binding--dependent transport system inner membrane component family protein [KO:K15599 ]
DO78_3110 modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
DO78_2536 bacterial extracellular solute-binding family protein [KO:K02012 ]
DO78_2557 bacterial extracellular solute-binding family protein [KO:K02012 ]
DO78_2556 binding--dependent transport system inner membrane component family protein [KO:K02011 ]
DO78_2535 binding--dependent transport system inner membrane component family protein [KO:K02011 ]
DO78_1620 thiB; thiamin/thiamine pyrophosphate ABC transporter, thiamin/thiamine pyrophospate-binding protein [KO:K02064 ]
DO78_1621 thiP; thiamine/thiamine pyrophosphate ABC transporter, permease protein [KO:K02063 ]
DO78_1483 bacterial extracellular solute-binding family protein [KO:K11073 ]
DO78_1479 binding--dependent transport system inner membrane component family protein [KO:K11074 ]
DO78_1481 putative spermidine/putrescine ABC transporter, permease component I protein [KO:K11075 ]
DO78_2921 bacterial extracellular solute-binding family protein [KO:K11077 ]
DO78_2922 binding--dependent transport system inner membrane component family protein [KO:K11078 ]
DO78_2923 binding--dependent transport system inner membrane component family protein [KO:K11079 ]
DO78_2571 substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002 ]
DO78_1451 choX; choline ABC transporter, periplasmic binding family protein [KO:K02002 ]
DO78_2572 binding--dependent transport system inner membrane component family protein [KO:K02001 ]
DO78_149 substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K05845 ]
DO78_146 binding--dependent transport system inner membrane component family protein [KO:K05846 ]
DO78_148 putative osmoprotectant uptake system permease protein yehY [KO:K05846 ]
DO78_2366 bacterial extracellular solute-binding family protein [KO:K10117 ]
DO78_2367 binding--dependent transport system inner membrane component family protein [KO:K10118 ]
DO78_2368 binding--dependent transport system inner membrane component family protein [KO:K10119 ]
DO78_2207 bacterial extracellular solute-binding family protein [KO:K10236 ]
DO78_2208 binding--dependent transport system inner membrane component family protein [KO:K10237 ]
DO78_2209 binding--dependent transport system inner membrane component family protein [KO:K10238 ]
DO78_2760 sbpA; multiple sugar-binding periplasmic protein sbpA [KO:K10546 ]
DO78_2758 branched-chain amino acid transport system / permease component family protein [KO:K10547 ]
DO78_3035 branched-chain amino acid transport system / permease component family protein [KO:K23535 ]
DO78_2412 branched-chain amino acid transport system / permease component family protein [KO:K23535 ]
DO78_3034 branched-chain amino acid transport system / permease component family protein [KO:K23536 ]
DO78_2411 branched-chain amino acid transport system / permease component family protein [KO:K23536 ]
DO78_2528 binding--dependent transport system inner membrane component family protein [KO:K17316 ]
DO78_2527 binding--dependent transport system inner membrane component family protein [KO:K17317 ]
DO78_478 periplasmic binding s and sugar binding domain of LacI family protein [KO:K10439 ]
DO78_2817 periplasmic binding s and sugar binding domain of LacI family protein [KO:K10439 ]
DO78_477 branched-chain amino acid transport system / permease component family protein [KO:K10440 ]
DO78_2814 branched-chain amino acid transport system / permease component family protein [KO:K10440 ]
DO78_2815 branched-chain amino acid transport system / permease component family protein [KO:K10440 ]
DO78_2171 periplasmic binding s and sugar binding domain of LacI family protein [KO:K10543 ]
DO78_2972 xylF; D-xylose ABC transporter, D-xylose-binding protein [KO:K10543 ]
DO78_2173 branched-chain amino acid transport system / permease component family protein [KO:K10544 ]
DO78_2974 branched-chain amino acid transport system / permease component family protein [KO:K10544 ]
DO78_2684 periplasmic binding s and sugar binding domain of LacI family protein [KO:K17202 ]
DO78_2685 branched-chain amino acid transport system / permease component family protein [KO:K17203 ]
DO78_1504 periplasmic binding s and sugar binding domain of LacI family protein [KO:K17205 ]
DO78_1505 branched-chain amino acid transport system / permease component family protein [KO:K17206 ]
DO78_2497 bacterial extracellular solute-binding family protein [KO:K05813 ]
DO78_2498 binding--dependent transport system inner membrane component family protein [KO:K05814 ]
DO78_2499 binding--dependent transport system inner membrane component family protein [KO:K05815 ]
DO78_1974 pstC; phosphate ABC transporter, permease protein PstC [KO:K02037 ]
DO78_1975 pstA; phosphate ABC transporter, permease protein PstA [KO:K02038 ]
DO78_2771 bacterial extracellular solute-binding s, 3 family protein [KO:K09969 ]
DO78_666 bacterial extracellular solute-binding s, 3 family protein [KO:K09969 ]
DO78_667 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K09970 ]
DO78_670 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K09971 ]
DO78_2519 bacterial extracellular solute-binding s, 3 family protein [KO:K02424 ]
DO78_2520 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10009 ]
DO78_2997 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_3018 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_2779 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_3052 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_1646 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_2491 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_2270 branched-chain amino acid transport system / permease component family protein [KO:K01997 ]
DO78_2998 branched-chain amino acid transport system / permease component family protein [KO:K01995 K01998 ]
DO78_2271 branched-chain amino acid transport system / permease component family protein [KO:K01995 K01998 ]
DO78_1645 branched-chain amino acid transport system / permease component family protein [KO:K01998 ]
DO78_2492 branched-chain amino acid transport system / permease component family protein [KO:K01998 ]
DO78_2780 branched-chain amino acid transport system / permease component family protein [KO:K01998 ]
DO78_3019 branched-chain amino acid transport system / permease component family protein [KO:K01998 ]
DO78_3053 branched-chain amino acid transport system / permease component family protein [KO:K01998 ]
DO78_2784 binding--dependent transport system inner membrane component family protein [KO:K02072 ]
DO78_2384 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580 ]
DO78_2385 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580 ]
DO78_2383 binding--dependent transport system inner membrane component family protein [KO:K15581 ]
DO78_2382 binding--dependent transport system inner membrane component family protein [KO:K15582 ]
DO78_1458 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368 ]
DO78_1457 binding--dependent transport system inner membrane component family protein [KO:K12369 ]
DO78_1456 binding--dependent transport system inner membrane component family protein [KO:K12370 ]
DO78_2633 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15584 ]
DO78_2634 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15584 ]
DO78_2028 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13893 ]
DO78_2029 bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13893 ]
DO78_2027 binding--dependent transport system inner membrane component family protein [KO:K13894 ]
DO78_2026 binding--dependent transport system inner membrane component family protein [KO:K13895 ]
DO78_1259 cobalt uptake substrate-specific transmembrane region family protein [KO:K02007 ]
DO78_743 liporeleasing system, transmembrane, LolC/E family protein [KO:K09808 ]
DO78_1374 ABC transporter transmembrane region 2 family protein [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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