KEGG   PATHWAY: bcee02010
Entry
bcee02010                   Pathway                                
Name
ABC transporters - Brucella ceti TE28753-12
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bcee02010  ABC transporters
bcee02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Brucella ceti TE28753-12 [GN:bcee]
Gene
V568_100735  sulfate ABC transporter substrate-binding protein [KO:K02048]
V568_102094  sulfate ABC transporter substrate-binding protein [KO:K23163]
V568_102093  sulfate ABC transporter, permease CysT [KO:K02046]
V568_100737  sulfate transport system permease protein cysT [KO:K02046]
V568_102092  sulfate ABC transporter [KO:K02047]
V568_100738  sulfate ABC transporter [KO:K02047]
V568_102091  Sulfate transport atp-binding protein CYSA [KO:K02045] [EC:7.3.2.3]
V568_200123  Bacterial extracellular solute-binding protein, family 3 [KO:K15553]
V568_201080  sulfonate/nitrate/taurine transport system substrate-binding protein [KO:K15553]
V568_200121  ABC transporter related protein [KO:K15554]
V568_201079  Binding-protein-dependent transport systems inner membrane component [KO:K15554]
V568_200122  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
V568_201078  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
V568_101979  ABC transporter substrate-binding protein [KO:K15598]
V568_200006  molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
V568_200005  modB; molybdate ABC transporter permease [KO:K02018]
V568_200004  molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
V568_200624  iron(III)-binding periplasmic protein precursor [KO:K02012]
V568_200650  putative iron compound ABC transporter periplasmic iron compound-binding protein [KO:K02012]
V568_200625  binding-protein-dependent transport system inner membrane component [KO:K02011]
V568_200651  binding-protein-dependent transport system inner membrane protein [KO:K02011]
V568_200628  Fe(3+) ions import ATP-binding protein fbpC [KO:K02010] [EC:7.2.2.7]
V568_200649  iron compound ABC transporter, ATP-binding protein, hypothetical [KO:K02010] [EC:7.2.2.7]
V568_100307  tbpA; thiamine transporter substrate binding subunit [KO:K02064]
V568_100306  thiP; thiamine transporter membrane protein [KO:K02063]
V568_100305  thiamine transport ATP-binding protein ThiQ [KO:K02062] [EC:7.6.2.15]
V568_100454  spermidine/putrescine ABC transporter periplasmic protein [KO:K11073]
V568_100455  polyamine ABC transporter ATP-binding protein [KO:K11076] [EC:7.6.2.16]
V568_200209  binding-protein-dependent transport system inner membrane component [KO:K11078]
V568_100489  glycine betaine/L-proline-binding protein PROX [KO:K02002]
V568_100488  binding-protein-dependent transport system inner membrane protein [KO:K02001]
V568_101963  substrate-binding region of ABC-type glycine betaine transport system [KO:K05845]
V568_101964  Binding-protein-dependent transport systems inner membrane component [KO:K05846]
V568_101966  osmoprotectant transport system permease [KO:K05846]
V568_101965  ATP/GTP-binding site domain-containing protein A [KO:K05847] [EC:7.6.2.9]
V568_200662  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
V568_101946  sugar ABC transporter [KO:K10112] [EC:7.5.2.-]
V568_200127  ABC-type sugar transport system, ATPase component [KO:K10112] [EC:7.5.2.-]
V568_200843  extracellular solute-binding protein [KO:K10117]
V568_201056  binding-protein-dependent transport system inner membrane protein [KO:K10237]
V568_200398  chvE; multiple sugar-binding periplasmic receptor chvE precursor [KO:K10546]
V568_200399  sugar ABC transporter ATP-binding protein [KO:K10548] [EC:7.5.2.-]
V568_101079  mammalian cell entry related domain protein [KO:K02067]
V568_101081  ABC transporter permease [KO:K02066]
V568_101080  ABC transporter [KO:K02065]
V568_200093  simple sugar transport system substrate-binding protein [KO:K07335]
V568_200787  ABC transporter periplasmic-binding protein [KO:K07335]
V568_200096  Bacterial inner-membrane translocator [KO:K23535]
V568_200784  inner-membrane translocator [KO:K23535]
V568_200097  inner-membrane translocator [KO:K23536]
V568_200094  ABC transporter [KO:K23537]
V568_200781  ABC transporter ATP-binding protein [KO:K23537]
V568_200661  multiple sugar transport system permease [KO:K17317]
V568_200336  hypothetical protein [KO:K10439]
V568_101591  Periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
V568_200339  Bacterial inner-membrane translocator [KO:K10440]
V568_101592  ribose ABC transporter permease [KO:K10440]
V568_101593  ribose ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
V568_201104  periplasmic binding protein/LacI transcriptional regulator [KO:K10543]
V568_200160  D-xylose ABC transporter, D-xylose-binding protein [KO:K10543]
V568_201102  simple sugar transport system permease [KO:K10544]
V568_200158  Bacterial inner-membrane translocator [KO:K10544]
V568_201103  Ribose import ATP-binding protein rbsA 2 [KO:K10545] [EC:7.5.2.10]
V568_200159  xylose transporter ATP-binding subunit [KO:K10545] [EC:7.5.2.10]
V568_200485  ribose ABC transporter permease [KO:K17203]
V568_200484  ribose ABC transporter ATP-binding protein [KO:K17204]
V568_100431  periplasmic binding protein/LacI transcriptional regulator [KO:K17205]
V568_200692  sn-glycerol-3-phosphate transport system permease ugpE [KO:K05815]
V568_200691  sn-glycerol-3-phosphate import ATP-binding protein ugpC [KO:K05816] [EC:7.6.2.10]
V568_102262  phosphate ABC transporter periplasmic protein [KO:K02040]
V568_102261  phosphate ABC transporter permease [KO:K02037]
V568_102259  phosphate ABC transporter permease PstA [KO:K02038]
V568_102258  phosphate transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
V568_101381  lysine-arginine-ornithine-binding periplasmic protein [KO:K09969]
V568_200388  extracellular solute-binding protein family 3 [KO:K09969]
V568_101380  amino acid ABC transporter permease [KO:K09970]
V568_101377  amino acid ABC transporter, ATP-binding protein [KO:K09972] [EC:7.4.2.1]
V568_100112  polar amino acid transport system ATP-binding protein [KO:K09972] [EC:7.4.2.1]
V568_200669  polar amino acid transport system substrate-binding protein [KO:K02424]
V568_200668  Cystine transport system permease protein [KO:K10009]
V568_200981  leucine-specific binding protein precursor [KO:K01999]
V568_102197  livJ; Leu/Ile/Val-binding protein precursor [KO:K01999]
V568_200703  amino acid ABC transporter periplasmic amino-acid binding protein [KO:K01999]
V568_200382  Leu/Ile/Val-binding family protein [KO:K01999]
V568_100284  leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999]
V568_200117  Leu/Ile/Val-binding protein precursor [KO:K01999]
V568_200972  ABC-type branched-chain amino acid transport system, periplasmic component [KO:K01999]
V568_200137  ABC-type branched-chain amino acid transport system, periplasmic component [KO:K01999]
V568_100779  Leu/Ile/Val-binding protein family protein [KO:K01999]
V568_200980  permease protein [KO:K01997]
V568_200702  branched-chain amino acid transport system permease [KO:K01997]
V568_100276  branched-chain amino acid transport system permease [KO:K01997]
V568_200376  inner-membrane translocator [KO:K01997]
V568_200076  high-affinity branched-chain amino acid transport system permease livH [KO:K01997]
V568_200136  high-affinity branched-chain amino acid transport system permease livH [KO:K01997]
V568_200979  permease protein [KO:K01995 K01998]
V568_200135  branched-chain amino acid ABC transporter [KO:K01995 K01998]
V568_200375  inner-membrane translocator [KO:K01998]
V568_200701  branched-chain amino acid ABC transporter, permease protein [KO:K01998]
V568_100281  ABC transporter [KO:K01995]
V568_200112  branched-chain amino acid transport system ATP-binding protein [KO:K01995]
V568_200111  ABC transporter [KO:K01996]
V568_200134  ABC transporter [KO:K01996]
V568_200377  high-affinity branched-chain amino acid transport ATP-binding protein LIVF [KO:K01996]
V568_100282  branched-chain amino acid transport system ATP-binding protein [KO:K01996]
V568_200698  branched-chain amino acid transport system ATP-binding protein [KO:K01996]
V568_200978  high-affinity branched-chain amino acid transport ATP-binding protein LIVF [KO:K01996]
V568_102225  ABC transporter substrate-binding protein [KO:K02073]
V568_200373  lipoprotein [KO:K02073]
V568_200371  ABC transporter ATP-binding protein [KO:K02071 K02072]
V568_200816  extracellular solute-binding protein [KO:K15580]
V568_200817  peptide/nickel transport system substrate-binding protein [KO:K15580]
V568_200818  oligopeptide transport system permease OPPB [KO:K15581]
V568_200820  hypothetical protein [KO:K15582]
V568_200821  oligopeptide transport ATP-binding protein OPPD [KO:K10823 K15583]
V568_100479  hypothetical protein [KO:K12368]
V568_100482  peptide ABC transporter permease [KO:K12369]
V568_100483  binding-protein-dependent transport system inner membrane protein [KO:K12370]
V568_100484  ABC transporter ATPase [KO:K12371]
V568_200547  hypothetical protein [KO:K15584]
V568_200549  nickel transporter permease NikB [KO:K15585]
V568_200550  binding-protein-dependent transport system inner membrane component [KO:K15586]
V568_200551  nickel transporter ATP-binding protein NikD [KO:K15587] [EC:7.2.2.11]
V568_102204  ABC transporter permease [KO:K13894]
V568_102205  oligopeptide transport system permease protein OPPC [KO:K13895]
V568_102206  ABC transporter ATP-binding protein [KO:K13896]
V568_200194  flagellar hook-associated protein FlgK [KO:K09815]
V568_200192  ABC 3 transport family protein [KO:K09816]
V568_100703  cobalt transporter CbiM [KO:K02007]
V568_100701  cobalt ABC transporter permease CbiQ [KO:K02008]
V568_100700  cobalt ABC transporter ATP-binding protein [KO:K02006]
V568_100704  nickel ECF transporter periplasmic protein [KO:K10094]
V568_100702  CbiL protein [KO:K16915]
V568_101628  protein bioY [KO:K03523]
V568_100342  BioY protein [KO:K03523]
V568_101613  O-antigen export system permease protein RFBD [KO:K09690]
V568_101614  ABC transporter [KO:K09691] [EC:7.5.2.14]
V568_101295  general secretion pathway protein H [KO:K09808]
V568_101294  lipoprotein-releasing system ATP-binding protein lolD [KO:K09810] [EC:7.6.2.-]
V568_102105  heme exporter protein CcmD [KO:K02196]
V568_102106  heme exporter membrane protein CcmC [KO:K02195]
V568_102107  heme exporter protein CcmB [KO:K02194]
V568_102108  cytochrome c biogenesis protein CcmA [KO:K02193] [EC:7.6.2.5]
V568_101441  permease [KO:K07091]
V568_101442  YjgP/YjgQ family permease [KO:K11720]
V568_102038  ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
V568_201088  nitrous-oxide reductase [KO:K19341]
V568_201089  Copper transport ATP-binding protein NOSF [KO:K19340]
V568_100074  cell division transport system permease [KO:K09811]
V568_100073  ATP/GTP-binding protein [KO:K09812]
V568_200275  ABC transporter ATP-binding protein/permease [KO:K11085] [EC:7.5.2.6]
V568_100522  ABC transporter ATP-binding protein/permease [KO:K18893]
V568_200852  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
V568_100387  macB; macrolide export ATP-binding/permease protein macB [KO:K05685] [EC:7.6.2.-]
V568_100571  ABC transporter [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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