KEGG   PATHWAY: bgo03070
Entry
bgo03070                    Pathway                                
Name
Bacterial secretion system - Burkholderia gladioli ATCC 10248
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bgo03070  Bacterial secretion system
bgo03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia gladioli ATCC 10248 [GN:bgo]
Gene
BM43_5322  outer membrane efflux family protein [KO:K12340]
BM43_7042  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
BM43_7035  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
BM43_7028  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
BM43_7027  type III secretion, HrpO family protein [KO:K03227]
BM43_7040  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
BM43_7032  type III secretion, YscU/HrpY family protein [KO:K03229]
BM43_7031  type III secretion, HrcV family protein [KO:K03230]
BM43_7038  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
BM43_7029  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
BM43_7037  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
BM43_1444  gspD; type II secretion system protein D [KO:K02453]
BM43_1558  bacterial type II and III secretion system family protein [KO:K02453]
BM43_4744  bacterial type II and III secretion system family protein [KO:K02453]
BM43_1441  putative gspC [KO:K02452]
BM43_1552  type II secretion system (T2SS), F family protein [KO:K02455]
BM43_1442  gspF; type II secretion system protein F [KO:K02455]
BM43_4738  type II secretion system (T2SS), F family protein [KO:K02455]
BM43_1551  gspG; type II secretion system protein G [KO:K02456]
BM43_1440  gspG; type II secretion system protein G [KO:K02456]
BM43_1559  hypothetical protein [KO:K02456]
BM43_1560  hypothetical protein [KO:K02456]
BM43_4736  gspG; type II secretion system protein G [KO:K02456]
BM43_4745  hypothetical protein [KO:K02456]
BM43_4746  hypothetical protein [KO:K02456]
BM43_1439  gspH; type II secretion system protein H [KO:K02457]
BM43_1438  gspI; type II secretion system protein I [KO:K02458]
BM43_1437  hypothetical protein [KO:K02459]
BM43_1436  type II secretion system (T2SS), K family protein [KO:K02460]
BM43_1435  gspL; type II secretion system protein L [KO:K02461]
BM43_1434  type II secretion system (T2SS), M family protein [KO:K02462]
BM43_1553  hypothetical protein [KO:K02454] [EC:7.4.2.8]
BM43_1443  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
BM43_4739  type II/IV secretion system family protein [KO:K02454] [EC:7.4.2.8]
BM43_2032  secD; export membrane protein SecD [KO:K03072]
BM43_2031  secF; export membrane protein SecF [KO:K03074]
BM43_1671  secE; preprotein translocase, SecE subunit [KO:K03073]
BM43_388  secG; preprotein translocase, SecG subunit [KO:K03075]
BM43_1715  secY; preprotein translocase, SecY subunit [KO:K03076]
BM43_2033  yajC; preprotein translocase, YajC subunit [KO:K03210]
BM43_1397  yidC; membrane protein insertase, YidC/Oxa1 family [KO:K03217]
BM43_1899  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
BM43_1011  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
BM43_1051  secB; protein-export chaperone SecB [KO:K03071]
BM43_1920  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BM43_1779  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
BM43_2238  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
BM43_1780  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
BM43_1781  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
BM43_7574  transglycosylase SLT domain protein [KO:K03194]
BM43_62  transglycosylase SLT domain protein [KO:K03194]
BM43_61  trbC/VIRB2 family protein [KO:K03197]
BM43_60  type IV secretory pathway, VirB3-like family protein [KO:K03198]
BM43_57  type IV secretion system s family protein [KO:K03200]
BM43_7568  type IV secretion system s family protein [KO:K03200]
BM43_55  conjugal transfer family protein [KO:K03204]
BM43_7571  conjugal transfer family protein [KO:K03204]
BM43_58  trbL/VirB6 plasmid conjugal transfer family protein [KO:K03201]
BM43_7569  trbL/VirB6 plasmid conjugal transfer family protein [KO:K03201]
BM43_56  virB8 family protein [KO:K03203]
BM43_7572  bacterial conjugation TrbI-like family protein [KO:K03195]
BM43_54  bacterial conjugation TrbI-like family protein [KO:K03195]
BM43_59  ptlC; type IV secretion system protein ptlC [KO:K03199] [EC:7.4.2.8]
BM43_7566  cagE, TrbE, VirB, component of type IV transporter system family protein [KO:K03199] [EC:7.4.2.8]
BM43_7573  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
BM43_53  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
BM43_51  type IV secretory system Conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
BM43_6362  Rhs element Vgr family protein [KO:K11904]
BM43_2552  Rhs element Vgr family protein [KO:K11904]
BM43_4623  Rhs element Vgr family protein [KO:K11904]
BM43_4577  Rhs element Vgr family protein [KO:K11904]
BM43_2920  Rhs element Vgr family protein [KO:K11904]
BM43_7155  Rhs element Vgr family protein [KO:K11904]
BM43_5076  Rhs element Vgr family protein [KO:K11904]
BM43_7443  Rhs element Vgr family protein [KO:K11904]
BM43_1118  Rhs element Vgr family protein [KO:K11904]
BM43_4702  Rhs element Vgr family protein [KO:K11904]
BM43_4817  Rhs element Vgr family protein [KO:K11904]
BM43_2533  Rhs element Vgr family protein [KO:K11904]
BM43_597  Rhs element Vgr family protein [KO:K11904]
BM43_1799  type VI secretion system effector, Hcp1 family protein [KO:K11903]
BM43_7145  hcp1; protein hcp1 [KO:K11903]
BM43_1795  type VI secretion lipofamily protein [KO:K11906]
BM43_1807  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BM43_7160  hypothetical protein [KO:K11891]
BM43_1793  type IV/VI secretion system, DotU family domain protein [KO:K11892]
BM43_7159  type IV/VI secretion system, DotU family domain protein [KO:K11892]
BM43_1803  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BM43_7150  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BM43_7139  FHA domain protein [KO:K11913]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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