KEGG   PATHWAY: bra00450
Entry
bra00450                    Pathway                                
Name
Selenocompound metabolism - Bradyrhizobium sp. ORS 278
Class
Metabolism; Metabolism of other amino acids
Pathway map
bra00450  Selenocompound metabolism
bra00450

Organism
Bradyrhizobium sp. ORS 278 [GN:bra]
Gene
BRADO3525  Putative cystathionine beta-lyase (CBL; Beta-cystathionase; Cysteine lyase) [KO:K01760] [EC:4.4.1.13]
BRADO3914  metC; cystathionine beta-lyase, PLP-dependent (beta-cystathionase) [KO:K01760] [EC:4.4.1.13]
BRADO0994  metH; B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase [KO:K00548] [EC:2.1.1.13]
BRADO1871  Putative 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase) [KO:K00549] [EC:2.1.1.14]
BRADO2911  putative methylcobalamin:homocysteine methyltransferase (Methionine synthase) [KO:K00549] [EC:2.1.1.14]
BRADO5444  sufS; cysteine desulfurase [KO:K11717] [EC:2.8.1.7 4.4.1.16]
BRADO3544  sufS; cysteine desulfurase [KO:K11717] [EC:2.8.1.7 4.4.1.16]
BRADO6640  putative nucleotide-disulphide oxidoreductase; putative thioredoxin reductase (FAD binding domain) [KO:K00384] [EC:1.8.1.9]
BRADO5079  Putative thioredoxin reductase, FAD/NAD(P)-binding [KO:K00384] [EC:1.8.1.9]
BRADO1321  trxB; thioredoxin reductase, FAD/NAD(P)-binding [KO:K00384] [EC:1.8.1.9]
BRADO1584  putative thioredoxin reductase (FAD/NAD binding domain) [KO:K00384] [EC:1.8.1.9]
BRADO5193  putative CysN/CysC bifunctional enzyme: Sulfate adenylyltransferase (SAT) subunit 1 (N-terminal); Adenylyl-sulfate kinase (APS kinase)(C-terminal) [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BRADO1063  CysN/CysC bifunctional enzyme, ATP-sulfurylase large subunit and adenylyl sulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BRADO1064  cysD; ATP-sulfurylase, subunit 2 (ATP:sulfate adenylyltransferase) [KO:K00957] [EC:2.7.7.4]
BRADO5192  putative Sulfate adenylate transferase, subunit 2 (NodP-like) [KO:K00957] [EC:2.7.7.4]
BRADO3829  Methionyl-tRNA synthetase (EC 6.1.1.10) [KO:K01874] [EC:6.1.1.10]
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   
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