KEGG   PATHWAY: bse02010
Entry
bse02010                    Pathway                                
Name
ABC transporters - Bacillus selenitireducens
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bse02010  ABC transporters
bse02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bacillus selenitireducens [GN:bse]
Gene
Bsel_2922  extracellular solute-binding protein [KO:K05772]
Bsel_2921  binding-protein-dependent transport systems inner membrane component [KO:K05773]
Bsel_2920  ABC transporter related protein [KO:K06857] [EC:7.3.2.6]
Bsel_1301  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
Bsel_1300  binding-protein-dependent transport systems inner membrane component [KO:K15554]
Bsel_1299  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Bsel_2600  NMT1/THI5 like domain protein [KO:K15598]
Bsel_2599  binding-protein-dependent transport systems inner membrane component [KO:K15599]
Bsel_2598  ABC transporter related protein [KO:K15600]
Bsel_0333  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
Bsel_0332  molybdate ABC transporter, inner membrane subunit [KO:K02018]
Bsel_0331  ABC transporter related protein [KO:K02017] [EC:7.3.2.5]
Bsel_0525  extracellular solute-binding protein family 1 [KO:K02012]
Bsel_2640  extracellular solute-binding protein family 1 [KO:K02012]
Bsel_0526  binding-protein-dependent transport systems inner membrane component [KO:K02011]
Bsel_1121  binding-protein-dependent transport systems inner membrane component [KO:K02011]
Bsel_2641  binding-protein-dependent transport systems inner membrane component [KO:K02011]
Bsel_0524  ABC transporter related protein [KO:K02010] [EC:7.2.2.7]
Bsel_1119  ABC transporter related protein [KO:K02010] [EC:7.2.2.7]
Bsel_2643  ABC transporter related protein [KO:K02010] [EC:7.2.2.7]
Bsel_0168  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Bsel_0352  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Bsel_1379  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Bsel_0353  binding-protein-dependent transport systems inner membrane component [KO:K02001]
Bsel_0354  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
Bsel_1918  Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 K05846]
Bsel_1917  ABC transporter related protein [KO:K05847] [EC:7.6.2.9]
Bsel_2502  ABC transporter related protein [KO:K10112] [EC:7.5.2.-]
Bsel_1507  extracellular solute-binding protein family 1 [KO:K15770]
Bsel_1508  binding-protein-dependent transport systems inner membrane component [KO:K15771]
Bsel_1509  binding-protein-dependent transport systems inner membrane component [KO:K15772]
Bsel_2832  extracellular solute-binding protein family 1 [KO:K10117]
Bsel_2833  binding-protein-dependent transport systems inner membrane component [KO:K10118]
Bsel_2834  binding-protein-dependent transport systems inner membrane component [KO:K10119]
Bsel_0413  extracellular solute-binding protein family 1 [KO:K10188]
Bsel_0414  binding-protein-dependent transport systems inner membrane component [KO:K10189]
Bsel_0415  binding-protein-dependent transport systems inner membrane component [KO:K10190]
Bsel_1457  extracellular solute-binding protein family 1 [KO:K10236]
Bsel_1459  binding-protein-dependent transport systems inner membrane component [KO:K10237]
Bsel_1460  binding-protein-dependent transport systems inner membrane component [KO:K10238]
Bsel_0323  extracellular solute-binding protein family 1 [KO:K10240]
Bsel_0847  extracellular solute-binding protein family 1 [KO:K10240]
Bsel_0324  binding-protein-dependent transport systems inner membrane component [KO:K10241]
Bsel_0325  binding-protein-dependent transport systems inner membrane component [KO:K10242]
Bsel_0335  extracellular solute-binding protein family 1 [KO:K17234]
Bsel_0336  binding-protein-dependent transport systems inner membrane component [KO:K17235]
Bsel_0337  binding-protein-dependent transport systems inner membrane component [KO:K17236]
Bsel_2552  basic membrane lipoprotein [KO:K07335]
Bsel_2550  inner-membrane translocator [KO:K23535]
Bsel_2549  inner-membrane translocator [KO:K23536]
Bsel_2551  ABC transporter related protein [KO:K23537]
Bsel_0912  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Bsel_0911  inner-membrane translocator [KO:K10440]
Bsel_0910  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
Bsel_0909  RbsD or FucU transport [KO:K06726] [EC:5.4.99.62]
Bsel_2901  extracellular solute-binding protein family 1 [KO:K05813]
Bsel_2903  binding-protein-dependent transport systems inner membrane component [KO:K05814]
Bsel_2902  binding-protein-dependent transport systems inner membrane component [KO:K05815]
Bsel_2904  ABC transporter related protein [KO:K05816] [EC:7.6.2.10]
Bsel_1466  phosphate binding protein [KO:K02040]
Bsel_1467  phosphate ABC transporter, inner membrane subunit PstC [KO:K02037]
Bsel_1468  phosphate ABC transporter, inner membrane subunit PstA [KO:K02038]
Bsel_1469  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:7.3.2.1]
Bsel_0349  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
Bsel_2596  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
Bsel_0350  membrane channel protein component of Pn transporter [KO:K02042]
Bsel_2593  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
Bsel_2594  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
Bsel_0351  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
Bsel_2595  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
Bsel_2578  extracellular solute-binding protein family 3 [KO:K10036]
Bsel_2579  polar amino acid ABC transporter, inner membrane subunit [KO:K10037]
Bsel_2580  ABC transporter related protein [KO:K10038] [EC:7.4.2.1]
Bsel_0491  extracellular solute-binding protein family 3 [KO:K02424]
Bsel_0490  polar amino acid ABC transporter, inner membrane subunit [KO:K10009]
Bsel_1149  NLPA lipoprotein [KO:K02073]
Bsel_1148  binding-protein-dependent transport systems inner membrane component [KO:K02072]
Bsel_1147  ABC transporter related protein [KO:K02071]
Bsel_0964  extracellular solute-binding protein family 5 [KO:K13889]
Bsel_0963  binding-protein-dependent transport systems inner membrane component [KO:K13890]
Bsel_0962  binding-protein-dependent transport systems inner membrane component [KO:K13891]
Bsel_2427  periplasmic solute binding protein [KO:K19975]
Bsel_2335  ABC-3 protein [KO:K19976]
Bsel_2336  ABC transporter related protein [KO:K19973] [EC:7.2.2.5]
Bsel_2250  periplasmic solute binding protein [KO:K09815]
Bsel_2329  ABC-3 protein [KO:K09816]
Bsel_2330  ABC-3 protein [KO:K09816]
Bsel_2331  ABC transporter related protein [KO:K09817] [EC:7.2.2.20]
Bsel_1188  BioY protein [KO:K03523]
Bsel_0146  cobalt transport protein [KO:K16785]
Bsel_0144  ABC transporter related protein [KO:K16786] [EC:7.-.-.-]
Bsel_0145  ABC transporter related protein [KO:K16787] [EC:7.-.-.-]
Bsel_0243  protein of unknown function DUF214 [KO:K09813]
Bsel_0244  ABC transporter related protein [KO:K09814] [EC:7.6.2.-]
Bsel_2652  protein of unknown function DUF214 [KO:K11632]
Bsel_2651  ABC transporter related protein [KO:K11631]
Bsel_1315  cytochrome c assembly protein [KO:K02195]
Bsel_1314  cytochrome c-type biogenesis protein CcmB [KO:K02194]
Bsel_1313  heme exporter protein CcmA [KO:K02193] [EC:7.6.2.5]
Bsel_1081  protein of unknown function DUF214 [KO:K09811]
Bsel_1080  cell division ATP-binding protein FtsE [KO:K09812]
Bsel_3198  hypothetical protein [KO:K16919]
Bsel_2510  hypothetical protein [KO:K16919]
Bsel_3199  ABC transporter related protein [KO:K16921]
Bsel_2509  ABC transporter related protein [KO:K16921]
Bsel_0360  ABC transporter related protein [KO:K18889]
Bsel_1683  ABC transporter related protein [KO:K18889]
Bsel_1684  ABC transporter related protein [KO:K18890]
Bsel_0361  ABC transporter related protein [KO:K18890]
Bsel_2804  ABC transporter related protein [KO:K18887]
Bsel_2803  ABC transporter related protein [KO:K18888]
Bsel_0546  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012]
Bsel_0668  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012]
Bsel_0545  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
Bsel_0667  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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