KEGG   PATHWAY: bsw02010
Entry
bsw02010                    Pathway                                
Name
ABC transporters - Brucella suis ZW043
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bsw02010  ABC transporters
bsw02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Brucella suis ZW043 [GN:bsw]
Gene
IY71_06585  thiosulfate transporter subunit [KO:K02048]
IY71_06580  sulfate/thiosulfate transporter subunit [KO:K02046]
IY71_06575  sulfate ABC transporter permease [KO:K02047]
IY71_16945  bicyclomycin resistance protein [KO:K15553]
IY71_12480  ABC transporter substrate-binding protein [KO:K15553]
IY71_16955  ABC transporter permease [KO:K15554]
IY71_12485  ABC transporter permease [KO:K15554]
IY71_16950  ATP-binding protein [KO:K15555] [EC:7.6.2.14]
IY71_12490  nitrate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
IY71_01170  ABC transporter ATP-binding protein [KO:K15598]
IY71_01160  ABC transporter permease [KO:K15599]
IY71_11545  molybdate ABC transporter substrate-binding protein [KO:K02020]
IY71_11550  molybdate ABC transporter permease [KO:K02018]
IY71_11555  molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
IY71_14530  iron ABC transporter substrate-binding protein [KO:K02012]
IY71_14630  iron ABC transporter substrate-binding protein [KO:K02012]
IY71_14525  iron ABC transporter permease [KO:K02011]
IY71_14625  iron ABC transporter permease [KO:K02011]
IY71_14535  iron ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
IY71_14620  sugar ABC transporter substrate-binding protein [KO:K02010] [EC:7.2.2.7]
IY71_08640  tbpA; thiamine ABC transporter substrate-binding protein [KO:K02064]
IY71_08645  thiamine ABC transporter permease [KO:K02063]
IY71_08650  thiamine ABC transporter ATP-binding protein [KO:K02062] [EC:7.6.2.15]
IY71_07905  ABC transporter substrate-binding protein [KO:K11077]
IY71_16495  ABC transporter substrate-binding protein [KO:K11077]
IY71_07915  ABC transporter permease [KO:K11078]
IY71_16505  ABC transporter permease [KO:K11078]
IY71_07920  ABC transporter permease [KO:K11079]
IY71_16510  ABC transporter permease [KO:K11079]
IY71_07930  sulfate ABC transporter ATP-binding protein [KO:K11080]
IY71_16520  sulfate ABC transporter ATP-binding protein [KO:K11080]
IY71_07735  glycine/betaine ABC transporter substrate-binding protein [KO:K02002]
IY71_14705  glycine/betaine ABC transporter substrate-binding protein [KO:K02002]
IY71_07740  ABC transporter permease [KO:K02001]
IY71_14710  glycine/betaine ABC transporter [KO:K02001]
IY71_07745  hemolysin [KO:K02000] [EC:7.6.2.9]
IY71_14715  glycine/betaine ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
IY71_01235  ABC transporter [KO:K05845]
IY71_01220  ABC transporter [KO:K05846]
IY71_01230  ABC transporter permease [KO:K05846]
IY71_01225  amino acid ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
IY71_13660  glycerol-3-phosphate ABC transporter ATPase [KO:K10111] [EC:7.5.2.-]
IY71_01295  sugar ABC transporter ATPase [KO:K10112] [EC:7.5.2.-]
IY71_14740  ATP-binding protein [KO:K10112] [EC:7.5.2.-]
IY71_16930  glycerol-3-phosphate ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
IY71_13635  sugar ABC transporter substrate-binding protein [KO:K10117]
IY71_13645  ABC transporter permease [KO:K10118]
IY71_13650  sugar ABC transporter permease [KO:K10119]
IY71_15680  sugar ABC transporter substrate-binding protein [KO:K10546]
IY71_15665  ABC transporter permease [KO:K10547]
IY71_15670  ABC transporter ATP-binding protein [KO:K10548] [EC:7.5.2.-]
IY71_05075  ABC transporter substrate-binding protein [KO:K02067]
IY71_05065  toluene ABC transporter permease [KO:K02066]
IY71_05070  iron ABC transporter ATP-binding protein [KO:K02065]
IY71_11170  adenine nucleotide translocator 1 [KO:K07335]
IY71_00765  DNA-binding protein [KO:K07335]
IY71_13905  DNA-binding protein [KO:K07335]
IY71_13915  sugar ABC transporter permease [KO:K23535]
IY71_00755  sugar ABC transporter permease [KO:K23535]
IY71_13910  ABC transporter permease [KO:K23536]
IY71_17055  ABC transporter permease [KO:K23536]
IY71_00760  ABC transporter permease [KO:K23536]
IY71_11165  sugar ABC transporter ATP-binding protein [KO:K23537]
IY71_00750  ABC transporter [KO:K23537]
IY71_13920  ABC transporter [KO:K23537]
IY71_14495  sugar ABC transporter substrate-binding protein [KO:K17315]
IY71_14490  ABC transporter permease [KO:K17316]
IY71_14485  sugar ABC transporter permease [KO:K17317]
IY71_15970  ABC transporter substrate-binding protein [KO:K10439]
IY71_02785  ABC transporter substrate-binding protein [KO:K10439]
IY71_02780  ABC transporter permease [KO:K10440]
IY71_15955  ABC transporter permease [KO:K10440]
IY71_15960  ABC transporter permease [KO:K10440]
IY71_02775  ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
IY71_15965  ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
IY71_16775  sugar ABC transporter substrate-binding protein [KO:K10543]
IY71_12385  ABC transporter substrate-binding protein [KO:K10543]
IY71_16785  D-xylose ABC transporter permease [KO:K10544]
IY71_12395  ABC transporter permease [KO:K10544]
IY71_16780  xylose transporter [KO:K10545] [EC:7.5.2.10]
IY71_12390  sugar ABC transporter ATP-binding protein [KO:K10545] [EC:7.5.2.10]
IY71_15295  sugar ABC transporter substrate-binding protein [KO:K17202]
IY71_15300  sugar ABC transporter permease [KO:K17203]
IY71_15305  sugar ABC transporter ATP-binding protein [KO:K17204]
IY71_08055  sugar ABC transporter substrate-binding protein [KO:K17205]
IY71_08060  sugar ABC transporter permease [KO:K17206]
IY71_08065  D-ribose transporter ATP-binding protein [KO:K17207]
IY71_14330  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
IY71_14335  glycerol-3-phosphate transporter permease [KO:K05814]
IY71_14340  glycerol-3-phosphate transporter membrane protein [KO:K05815]
IY71_14345  sugar ABC transporter ATPase [KO:K05816] [EC:7.6.2.10]
IY71_10790  phosphonate ABC transporter substrate-binding protein [KO:K02040]
IY71_10795  phosphate ABC transporter permease [KO:K02037]
IY71_10800  phosphate ABC transporter permease [KO:K02038]
IY71_10805  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
IY71_03735  amino acid ABC transporter substrate-bindnig protein [KO:K09969]
IY71_15740  amino acid ABC transporter substrate-binding protein [KO:K09969]
IY71_03740  amino acid ABC transporter permease [KO:K09970]
IY71_03745  amino acid ABC transporter permease [KO:K09971]
IY71_03750  ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
IY71_09600  glnQ; glutamine ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
IY71_14445  amino acid ABC transporter substrate-binding protein [KO:K02424]
IY71_14450  cysteine ABC transporter permease [KO:K10009]
IY71_14455  ATP-binding protein [KO:K10010] [EC:7.4.2.1]
IY71_16880  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
IY71_13025  amino acid-binding protein [KO:K01999]
IY71_13070  amino acid-binding protein [KO:K01999]
IY71_08745  amino acid ABC transporter substrate-binding protein [KO:K01999]
IY71_08750  amino acid ABC transporter substrate-binding protein [KO:K01999]
IY71_00375  amino acid-binding protein [KO:K01999]
IY71_06400  amino acid-binding protein [KO:K01999]
IY71_14295  amino acid-binding protein [KO:K01999]
IY71_11080  amino acid ABC transporter substrate-binding protein [KO:K01999]
IY71_11240  amino acid-binding protein [KO:K01999]
IY71_15765  ABC transporter permease [KO:K01999]
IY71_16975  amino acid ABC transporter substrate-binding protein [KO:K01999]
IY71_16885  branched-chain amino acid ABC transporter permease [KO:K01997]
IY71_13030  branched-chain amino acid ABC transporter permease [KO:K01997]
IY71_08775  branched-chain amino acid transporter permease subunit LivH [KO:K01997]
IY71_00370  ABC transporter permease [KO:K01997]
IY71_14300  ABC transporter permease [KO:K01997]
IY71_11245  ABC transporter permease [KO:K01997]
IY71_15780  ABC transporter permease [KO:K01997]
IY71_16980  branched-chain amino acid ABC transporter permease [KO:K01997]
IY71_16890  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995 K01998]
IY71_13040  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995 K01998]
IY71_00365  branched-chain amino acid ABC transporter permease [KO:K01998]
IY71_08770  ABC transporter permease [KO:K01998]
IY71_11250  branched-chain amino acid ABC transporter permease [KO:K01998]
IY71_14305  branched-chain amino acid ABC transporter permease [KO:K01998]
IY71_15785  ABC transporter permease [KO:K01998]
IY71_08765  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
IY71_00360  hemolysin III [KO:K01995]
IY71_14310  hemolysin III [KO:K01995]
IY71_11255  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01995]
IY71_15770  amino acid ABC transporter ATP-binding protein [KO:K01995]
IY71_16990  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
IY71_11260  mannosyltransferase [KO:K01996]
IY71_13045  livF; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01996]
IY71_15775  histidinol dehydrogenase [KO:K01996]
IY71_16895  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
IY71_16995  livF; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01996]
IY71_10960  dioxygenase [KO:K02073]
IY71_15800  ABC transporter substrate-binding protein [KO:K02073]
IY71_15810  ABC transporter permease [KO:K02072]
IY71_15805  methionine ABC transporter ATP-binding protein [KO:K02071]
IY71_13730  ABC transporter substrate-binding protein [KO:K15580]
IY71_13735  ABC transporter substrate-binding protein [KO:K15580]
IY71_00020  ABC transporter [KO:K15581]
IY71_13725  ABC transporter [KO:K15581]
IY71_13720  peptide ABC transporter permease [KO:K15582]
IY71_00015  peptide ABC transporter permease [KO:K15582]
IY71_13715  microcin ABC transporter ATP-binding protein [KO:K10823 K15583]
IY71_00010  microcin ABC transporter ATP-binding protein [KO:K10823 K15583]
IY71_07750  peptide ABC transporter ATP-binding protein [KO:K12372]
IY71_15030  nickel ABC transporter substrate-binding protein [KO:K15584]
IY71_15025  nickel transporter permease NikB [KO:K15585]
IY71_15020  nikC; nickel transporter permease NikC [KO:K15586]
IY71_15015  nikD; nickel ABC transporter ATP-binding protein [KO:K15587] [EC:7.2.2.11]
IY71_15010  nikE; nickel ABC transporter ATP-binding protein [KO:K10824] [EC:7.2.2.11]
IY71_11060  hypothetical protein [KO:K13893]
IY71_11065  hypothetical protein [KO:K13893]
IY71_11055  microcin ABC transporter permease [KO:K13894]
IY71_11050  peptide ABC transporter permease [KO:K13895]
IY71_11045  microcin ABC transporter ATP-binding protein [KO:K13896]
IY71_16630  zinc transporter [KO:K09815]
IY71_16640  membrane protein [KO:K09816]
IY71_16635  zinc ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
IY71_06735  cobalamin biosynthesis protein CbiM [KO:K02007]
IY71_06745  cobalt ABC transporter permease [KO:K02008]
IY71_06750  cobalt ABC transporter ATP-binding protein [KO:K02006]
IY71_06730  ATP-dependent DNA ligase [KO:K10094]
IY71_06740  cobalamin biosynthesis protein CbiM [KO:K16915]
IY71_02570  biotin biosynthesis protein BioY [KO:K03523]
IY71_08470  biotin biosynthesis protein BioY [KO:K03523]
IY71_02650  ABC transporter permease [KO:K09690]
IY71_02645  teichoic acid ABC transporter ATPase [KO:K09691] [EC:7.5.2.14]
IY71_04115  multidrug ABC transporter substrate-binding protein [KO:K09808]
IY71_04120  ABC transporter [KO:K09810] [EC:7.6.2.-]
IY71_00350  transcriptional regulator [KO:K02196]
IY71_00345  heme transporter HemC [KO:K02195]
IY71_00340  heme transporter [KO:K02194]
IY71_00335  cytochrome C biogenesis protein CcmA [KO:K02193] [EC:7.6.2.5]
IY71_03470  permease [KO:K07091]
IY71_03465  permease [KO:K11720]
IY71_00920  ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
IY71_12450  membrane protein [KO:K19341]
IY71_12445  ABC transporter ATP-binding protein [KO:K19340]
IY71_09795  cell division protein FtsX [KO:K09811]
IY71_09800  cell division protein FtsE [KO:K09812]
IY71_16235  ABC transporter ATP-binding protein [KO:K11085] [EC:7.5.2.6]
IY71_02265  metal ABC transporter permease [KO:K24821]
IY71_07575  multidrug ABC transporter ATP-binding protein [KO:K18893]
IY71_13605  ABC transporter ATP-binding protein [KO:K16012]
IY71_13600  ABC transporter ATP-binding protein [KO:K16013]
IY71_08250  macrolide ABC transporter ATP-binding protein [KO:K05685] [EC:7.6.2.-]
IY71_07320  glycosyl transferase family 1 [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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