KEGG   PATHWAY: but03070
Entry
but03070                    Pathway                                
Name
Bacterial secretion system - Burkholderia pseudomallei TSV202
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
but03070  Bacterial secretion system
but03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia pseudomallei TSV202 [GN:but]
Gene
X994_3045  outer membrane efflux family protein [KO:K12340]
X994_5840  outer membrane efflux family protein [KO:K12340]
X994_5569  eprI; type III secretion apparatus needle protein [KO:K03221]
X994_5518  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
X994_5728  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
X994_5721  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
X994_5486  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
X994_5714  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
X994_5493  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
X994_5494  type III secretion , HrpO family protein [KO:K03227]
X994_5713  type III secretion , HrpO family protein [KO:K03227]
X994_5726  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
X994_5481  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
X994_5718  type III secretion , YscU/HrpY family protein [KO:K03229]
X994_5489  type III secretion , YscU/HrpY family protein [KO:K03229]
X994_5574  invA; invasion protein invA [KO:K03230]
X994_5717  type III secretion , HrcV family protein [KO:K03230]
X994_5490  type III secretion , HrcV family protein [KO:K03230]
X994_5724  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
X994_5483  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
X994_5579  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
X994_5715  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
X994_5492  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
X994_5723  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
X994_5484  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
X994_2660  gspD; type II secretion system protein D [KO:K02453]
X994_2657  type IV pilus biogenesis family protein [KO:K02452]
X994_2658  gspF; type II secretion system protein F [KO:K02455]
X994_2656  gspG; type II secretion system protein G [KO:K02456]
X994_2655  gspH; type II secretion system protein H [KO:K02457]
X994_2654  gspI; type II secretion system protein I [KO:K02458]
X994_2653  hypothetical protein [KO:K02459]
X994_2652  type II secretion system (T2SS), K family protein [KO:K02460]
X994_2651  gspL; type II secretion system protein L [KO:K02461]
X994_2650  type II secretion system (T2SS), M family protein [KO:K02462]
X994_2659  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
X994_5513  type II/IV secretion system family protein [KO:K02454] [EC:7.4.2.8]
X994_3284  secD; export membrane protein SecD [KO:K03072]
X994_3283  secF; export membrane protein SecF [KO:K03074]
X994_2906  secE; preprotein translocase, SecE subunit [KO:K03073]
X994_1525  secG; preprotein translocase, SecG subunit [KO:K03075]
X994_2940  secY; preprotein translocase, SecY subunit [KO:K03076]
X994_3285  yajC; preprotein translocase, YajC subunit [KO:K03210]
X994_2586  yidC; membrane protein insertase, YidC/Oxa1 family [KO:K03217]
X994_3133  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
X994_2180  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
X994_2251  secB; protein-export chaperone SecB [KO:K03071]
X994_3155  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
X994_3006  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
X994_3007  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
X994_3008  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
X994_6594  transglycosylase SLT domain protein [KO:K03194]
X994_6596  trbC/VIRB2 family protein [KO:K03197]
X994_6597  type IV secretory pathway, VirB3-like family protein [KO:K03198]
X994_6599  virB5; P-type DNA transfer protein VirB5 [KO:K03200]
X994_6603  virB9; P-type conjugative transfer protein VirB9 [KO:K03204]
X994_6601  trbL/VirB6 plasmid conjugal transfer family protein [KO:K03201]
X994_6602  virB8; type IV secretion system protein virB8 [KO:K03203]
X994_6604  bacterial conjugation TrbI-like family protein [KO:K03195]
X994_6598  ptlC; type IV secretion system protein ptlC [KO:K03199] [EC:7.4.2.8]
X994_6605  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
X994_6607  type IV secretory system Conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
X994_4966  Rhs element Vgr family protein [KO:K11904]
X994_5023  Rhs element Vgr family protein [KO:K11904]
X994_4498  Rhs element Vgr family protein [KO:K11904]
X994_4577  Rhs element Vgr family protein [KO:K11904]
X994_4095  Rhs element Vgr family protein [KO:K11904]
X994_4096  Rhs element Vgr family protein [KO:K11904]
X994_5612  Rhs element Vgr family protein [KO:K11904]
X994_6163  Rhs element Vgr family protein [KO:K11904]
X994_1231  Rhs element Vgr family protein [KO:K11904]
X994_4606  Rhs element Vgr family protein [KO:K11904]
X994_5926  Rhs element Vgr family protein [KO:K11904]
X994_4508  type VI secretion system effector, Hcp1 family protein [KO:K11903]
X994_4583  hypothetical protein [KO:K11903]
X994_4101  hypothetical protein [KO:K11903]
X994_3034  type VI secretion system effector, Hcp1 family protein [KO:K11903]
X994_5617  type VI secretion system effector, Hcp1 family protein [KO:K11903]
X994_4952  type VI secretion lipofamily protein [KO:K11906]
X994_4509  type VI secretion lipofamily protein [KO:K11906]
X994_4582  type VI secretion lipofamily protein [KO:K11906]
X994_4090  type VI secretion lipofamily protein [KO:K11906]
X994_3030  type VI secretion lipofamily protein [KO:K11906]
X994_4955  intracellular multiplication and macrophage-killing family protein [KO:K11891]
X994_4512  intracellular multiplication and macrophage-killing family protein [KO:K11891]
X994_4579  intracellular multiplication and macrophage-killing family protein [KO:K11891]
X994_4087  intracellular multiplication and macrophage-killing family protein [KO:K11891]
X994_3042  intracellular multiplication and macrophage-killing family protein [KO:K11891]
X994_5604  hypothetical protein [KO:K11891]
X994_4954  type VI secretion system peptidoglycan-associated domain protein [KO:K11892]
X994_4511  type VI secretion system peptidoglycan-associated domain protein [KO:K11892]
X994_4580  type VI secretion system peptidoglycan-associated domain protein [KO:K11892]
X994_4587  hypothetical protein [KO:K11892]
X994_4088  type IV/VI secretion system , DotU family domain protein [KO:K11892]
X994_3028  type IV/VI secretion system , DotU family domain protein [KO:K11892]
X994_5605  type IV/VI secretion system , DotU family domain protein [KO:K11892]
X994_4965  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
X994_4505  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
X994_4566  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
X994_4097  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
X994_3038  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
X994_5613  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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