KEGG   PATHWAY: cauf02020
Entry
cauf02020                   Pathway                                
Name
Two-component system - Caulobacter sp. FWC26
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
cauf02020  Two-component system
cauf02020

Other DBs
GO: 0000160
Organism
Caulobacter sp. FWC26 [GN:cauf]
Gene
CSW63_21105  PAS domain-containing protein [KO:K07636] [EC:2.7.13.3]
CSW63_21080  phoB; phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
CSW63_07830  response regulator [KO:K07657]
CSW63_04000  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
CSW63_06505  alkaline phosphatase family protein [KO:K01113] [EC:3.1.3.1]
CSW63_10735  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
CSW63_04305  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
CSW63_05195  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
CSW63_15215  phosphate ABC transporter substrate-binding protein [KO:K02040]
CSW63_20750  phosphatase PAP2 family protein [KO:K09474] [EC:3.1.3.2]
CSW63_06785  HAMP domain-containing protein [KO:K07638] [EC:2.7.13.3]
CSW63_06795  response regulator [KO:K07659]
CSW63_17920  Do family serine endopeptidase [KO:K04771] [EC:3.4.21.107]
CSW63_21905  serine protease [KO:K04771] [EC:3.4.21.107]
CSW63_01250  copper-binding protein [KO:K07810]
CSW63_01045  copper-binding protein [KO:K07810]
CSW63_01030  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
CSW63_01240  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
CSW63_01035  efflux RND transporter permease subunit [KO:K07787]
CSW63_01245  efflux RND transporter permease subunit [KO:K07787]
CSW63_19165  flagellin [KO:K02406]
CSW63_19170  flagellin [KO:K02406]
CSW63_13035  flagellin [KO:K02406]
CSW63_13045  flagellin [KO:K02406]
CSW63_13050  flagellin [KO:K02406]
CSW63_19365  motA; flagellar motor stator protein MotA [KO:K02556]
CSW63_03640  sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
CSW63_03635  response regulator [KO:K07667]
CSW63_03655  kdpA; potassium-transporting ATPase subunit KdpA [KO:K01546]
CSW63_03650  kdpB; K(+)-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
CSW63_03645  kdpC; potassium-transporting ATPase subunit KdpC [KO:K01548]
CSW63_13885  heme A synthase [KO:K02259] [EC:1.17.99.9]
CSW63_01645  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
CSW63_21375  HAMP domain-containing protein [KO:K14980] [EC:2.7.13.3]
CSW63_21380  DNA-binding response regulator [KO:K14981]
CSW63_16290  peptidase M15 [KO:K08641] [EC:3.4.13.22]
CSW63_17445  peptidase M15 [KO:K07260] [EC:3.4.17.14]
CSW63_22665  CoA ester lyase [KO:K01644] [EC:4.1.3.34]
CSW63_00605  CoA ester lyase [KO:K01644] [EC:4.1.3.34]
CSW63_03735  nitrate reductase subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
CSW63_03740  narH; nitrate reductase subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
CSW63_03750  narI; respiratory nitrate reductase subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
CSW63_03745  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
CSW63_11920  class A beta-lactamase-related serine hydrolase [KO:K01467] [EC:3.5.2.6]
CSW63_09055  sensor histidine kinase [KO:K07778] [EC:2.7.13.3]
CSW63_09060  DNA-binding response regulator [KO:K07693]
CSW63_18990  Flp family type IVb pilin [KO:K02651]
CSW63_06700  Flp family type IVb pilin [KO:K02651]
CSW63_06710  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
CSW63_05135  hypothetical protein [KO:K02280]
CSW63_06715  type II and III secretion system protein family protein [KO:K02280]
CSW63_06725  pilus assembly protein CpaE [KO:K02282]
CSW63_05140  CpaF family protein [KO:K02283] [EC:7.4.2.8]
CSW63_06735  type II secretion system F family protein [KO:K12510]
CSW63_05155  hypothetical protein [KO:K12511]
CSW63_06740  type II secretion system F family protein [KO:K12511]
CSW63_01675  [protein-PII] uridylyltransferase [KO:K00990] [EC:2.7.7.59]
CSW63_12910  P-II family nitrogen regulator [KO:K04751]
CSW63_12075  nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
CSW63_12080  response regulator [KO:K07712]
CSW63_12915  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
CSW63_05825  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
CSW63_05865  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
CSW63_12085  PAS domain-containing sensor histidine kinase [KO:K13598] [EC:2.7.13.3]
CSW63_12090  sigma-54-dependent Fis family transcriptional regulator [KO:K13599]
CSW63_21235  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_02770  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_18710  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_12905  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_02210  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_05965  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
CSW63_11070  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_04570  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_13175  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_19215  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CSW63_04930  sensor histidine kinase [KO:K10125] [EC:2.7.13.3]
CSW63_04925  sigma-54-dependent Fis family transcriptional regulator [KO:K10126]
CSW63_04935  dicarboxylate/amino acid:cation symporter [KO:K11103]
CSW63_22350  rpoN; RNA polymerase sigma-54 factor [KO:K03092]
CSW63_02700  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
CSW63_03460  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
CSW63_11570  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
CSW63_08890  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
CSW63_21775  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
CSW63_02760  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_07160  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_07180  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_03325  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_03425  globin-coupled sensor protein [KO:K03406]
CSW63_03435  HAMP domain-containing protein [KO:K03406]
CSW63_16335  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_16540  PAS domain S-box protein [KO:K03406]
CSW63_16600  globin-coupled sensor protein [KO:K03406]
CSW63_20830  HAMP domain-containing protein [KO:K03406]
CSW63_21075  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_04540  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_08900  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_08905  HAMP domain-containing protein [KO:K03406]
CSW63_13350  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_21765  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_18260  globin-coupled sensor protein [KO:K03406]
CSW63_18820  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_01915  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_06495  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_15080  methyl-accepting chemotaxis protein [KO:K03406]
CSW63_06315  purine-binding chemotaxis protein CheW [KO:K03408]
CSW63_19305  purine-binding chemotaxis protein CheW [KO:K03408]
CSW63_03455  chemotaxis protein CheW [KO:K03408]
CSW63_16535  purine-binding chemotaxis protein CheW [KO:K03408]
CSW63_08895  chemotaxis protein CheW [KO:K03408]
CSW63_21760  chemotaxis protein CheW [KO:K03408]
CSW63_21770  chemotaxis protein CheW [KO:K03408]
CSW63_08910  chemotaxis protein CheW [KO:K03408]
CSW63_03450  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CSW63_08915  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CSW63_21755  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CSW63_02705  response regulator [KO:K03413]
CSW63_03445  response regulator [KO:K03413]
CSW63_03470  response regulator [KO:K03413]
CSW63_21750  response regulator [KO:K03413]
CSW63_08920  response regulator [KO:K03413]
CSW63_16160  response regulator [KO:K03413]
CSW63_13940  response regulator [KO:K03413]
CSW63_03465  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
CSW63_11565  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
CSW63_08885  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
CSW63_21780  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
CSW63_08340  PAS domain-containing protein [KO:K07716] [EC:2.7.13.3]
CSW63_08440  PleD family two-component system response regulator [KO:K02488] [EC:2.7.7.65]
CSW63_17265  sensor histidine kinase [KO:K11357] [EC:2.7.13.3]
CSW63_08435  response regulator [KO:K11443]
CSW63_17180  response regulator [KO:K13587] [EC:2.7.13.3]
CSW63_02710  histidine phosphotransferase [KO:K13588]
CSW63_06265  DNA-binding response regulator [KO:K13584]
CSW63_19510  response regulator [KO:K13589]
CSW63_01180  PAS domain S-box protein [KO:K14986] [EC:2.7.13.3]
CSW63_19340  PAS domain-containing sensor histidine kinase [KO:K14986] [EC:2.7.13.3]
CSW63_01195  DNA-binding response regulator [KO:K14987]
CSW63_19345  response regulator [KO:K14987]
CSW63_15125  response regulator [KO:K14987]
CSW63_01175  DNA-binding response regulator [KO:K14987]
CSW63_19355  transcriptional regulator [KO:K15861]
CSW63_18625  sigma-54-dependent Fis family transcriptional regulator [KO:K10943]
CSW63_21180  glutaminase [KO:K01425] [EC:3.5.1.2]
CSW63_21320  sensor histidine kinase [KO:K15011] [EC:2.7.13.3]
CSW63_21325  DNA-binding response regulator [KO:K15012]
CSW63_04390  petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
CSW63_04400  cytochrome c1 [KO:K00413]
CSW63_04395  cytochrome b/b6 [KO:K00410]
CSW63_11540  cytochrome c family protein [KO:K08738]
CSW63_09350  cytochrome c family protein [KO:K08738]
CSW63_06765  cytochrome c family protein [KO:K08738]
CSW63_13340  ccoN; cytochrome-c oxidase, cbb3-type subunit I [KO:K00404] [EC:7.1.1.9]
CSW63_13335  ccoO; cytochrome-c oxidase, cbb3-type subunit II [KO:K00405]
CSW63_13330  CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone [KO:K00407]
CSW63_13325  ccoP; cytochrome-c oxidase, cbb3-type subunit III [KO:K00406]
CSW63_19320  cytochrome bd-I ubiquinol oxidase subunit CydA [KO:K00425] [EC:7.1.1.7]
CSW63_19315  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
CSW63_19310  cydX; cytochrome bd-I oxidase subunit CydX [KO:K00424] [EC:7.1.1.7]
CSW63_14180  hypothetical protein [KO:K12340]
CSW63_14910  channel protein TolC [KO:K12340]
CSW63_17510  hypothetical protein [KO:K12340]
CSW63_16860  low molecular weight phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
CSW63_16020  glycosyl hydrolase [KO:K01179] [EC:3.2.1.4]
CSW63_03935  FecR family protein [KO:K07165]
CSW63_03990  DUF4880 domain-containing protein [KO:K07165]
CSW63_13400  DUF4880 domain-containing protein [KO:K07165]
CSW63_13435  FecR family protein [KO:K07165]
CSW63_13615  DUF4880 domain-containing protein [KO:K07165]
CSW63_17890  DUF4880 domain-containing protein [KO:K07165]
CSW63_20350  DUF4880 domain-containing protein [KO:K07165]
CSW63_19425  DUF4880 domain-containing protein [KO:K07165]
CSW63_14560  FecR family protein [KO:K07165]
CSW63_00130  DUF4880 domain-containing protein [KO:K07165]
CSW63_17675  DUF4880 domain-containing protein [KO:K07165]
CSW63_08815  FecR family protein [KO:K07165]
CSW63_07330  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_16495  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_18255  PAS domain S-box protein [KO:K20974] [EC:2.7.13.3]
CSW63_22410  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_22475  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_05600  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_05730  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_06015  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_19540  response regulator [KO:K20974] [EC:2.7.13.3]
CSW63_19830  response regulator [KO:K20974] [EC:2.7.13.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
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Related
pathway
cauf00190  Oxidative phosphorylation
cauf00550  Peptidoglycan biosynthesis
cauf00910  Nitrogen metabolism
cauf02030  Bacterial chemotaxis
cauf02040  Flagellar assembly
cauf03070  Bacterial secretion system
cauf04112  Cell cycle - Caulobacter
KO pathway
ko02020   
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