KEGG   PATHWAY: dwd02010
Entry
dwd02010                    Pathway                                
Name
ABC transporters - Desulfosarcina widdelii
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
dwd02010  ABC transporters
dwd02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Desulfosarcina widdelii [GN:dwd]
Gene
DSCW_54400  tungsten ABC transporter substrate-binding protein [KO:K05772]
DSCW_44820  ABC transporter substrate-binding protein [KO:K05772]
DSCW_54410  ABC transporter permease [KO:K05773]
DSCW_54420  hypothetical protein [KO:K06857] [EC:7.3.2.6]
DSCW_54620  tungstate ABC transporter substrate-binding protein WtpA [KO:K15495]
DSCW_54630  molybdenum ABC transporter permease [KO:K15496]
DSCW_54640  sulfate ABC transporter ATP-binding protein [KO:K15497] [EC:7.3.2.5 7.3.2.6]
DSCW_34530  taurine ABC transporter substrate-binding protein [KO:K15551]
DSCW_34520  ABC transporter permease [KO:K15552]
DSCW_58840  putative thiamine biosynthesis protein [KO:K15598]
DSCW_58850  ABC transporter permease [KO:K15599]
DSCW_58860  ABC transporter ATP-binding protein [KO:K15600]
DSCW_56370  molybdenum ABC transporter substrate-binding protein [KO:K02020]
DSCW_56380  molybdate ABC transporter permease [KO:K02018]
DSCW_56390  ABC transporter ATPase [KO:K02017] [EC:7.3.2.5]
DSCW_17430  molybdate ABC transporter ATP-binding protein ModF [KO:K05776]
DSCW_57760  putative 2-aminoethylphosphonate ABC transporter substrate-binding protein [KO:K02012]
DSCW_57740  phosphonate ABC transporter permease [KO:K02011]
DSCW_57750  fbpC; Fe(3+) ions import ATP-binding protein FbpC [KO:K02010] [EC:7.2.2.7]
DSCW_20760  hypothetical protein [KO:K11069]
DSCW_62320  hypothetical protein [KO:K11069]
DSCW_57430  potD-A; spermidine/putrescine-binding periplasmic protein 2 [KO:K11069]
DSCW_30430  spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069]
DSCW_62350  hypothetical protein [KO:K11070]
DSCW_20750  hypothetical protein [KO:K11070]
DSCW_57400  ornithine carbamoyltransferase [KO:K11070]
DSCW_30440  spermidine/putrescine ABC transporter permease [KO:K11070]
DSCW_20740  potB_1; spermidine/putrescine ABC transporter permease [KO:K11071]
DSCW_62340  potB_2; spermidine/putrescine ABC transporter permease [KO:K11071]
DSCW_57410  hypothetical protein [KO:K11071]
DSCW_30450  spermidine/putrescine ABC transporter permease [KO:K11071]
DSCW_62330  potG; polyamine-transporting ATPase [KO:K11072] [EC:7.6.2.11]
DSCW_57420  potA; spermidine/putrescine import ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
DSCW_30460  spermidine/putrescine ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
DSCW_20770  hypothetical protein [KO:K11072] [EC:7.6.2.11]
DSCW_18630  proX; glycine betaine ABC transporter substrate-binding protein [KO:K02002]
DSCW_18640  glycine/betaine ABC transporter permease [KO:K02001]
DSCW_18650  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
DSCW_43240  toluene tolerance protein [KO:K07323]
DSCW_35040  hypothetical protein [KO:K02067]
DSCW_43230  outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
DSCW_35060  ABC transporter permease [KO:K02066]
DSCW_43210  ABC transporter permease [KO:K02066]
DSCW_43220  ABC transporter ATP-binding protein [KO:K02065]
DSCW_40630  ABC transporter substrate-binding protein [KO:K07335]
DSCW_41970  ABC transporter substrate-binding protein [KO:K07335]
DSCW_40610  ABC transporter permease [KO:K23535]
DSCW_41990  ABC transporter permease [KO:K23535]
DSCW_40600  ABC transporter permease [KO:K23536]
DSCW_42000  ABC transporter permease [KO:K23536]
DSCW_40620  sugar ABC transporter [KO:K23537]
DSCW_41980  heme ABC transporter ATP-binding protein [KO:K23537]
DSCW_41350  ABC transporter substrate-binding protein [KO:K17321]
DSCW_41320  ABC transporter permease [KO:K17322]
DSCW_41330  ABC transporter permease [KO:K17323]
DSCW_41300  ABC transporter [KO:K17324]
DSCW_41310  ABC transporter ATP-binding protein [KO:K17325]
DSCW_42640  ugpB; sn-glycerol-3-phosphate-binding periplasmic protein UgpB [KO:K05813]
DSCW_57660  ABC transporter substrate-binding protein [KO:K05813]
DSCW_42650  glycerol-3-phosphate transporter permease [KO:K05814]
DSCW_57650  ABC transporter permease [KO:K05814]
DSCW_42660  ugpE; sn-glycerol-3-phosphate transport system permease protein UgpE [KO:K05815]
DSCW_57640  ABC transporter permease [KO:K05815]
DSCW_57670  sugar ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
DSCW_42630  sugar ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
DSCW_58520  phosphate ABC transporter substrate-binding protein [KO:K02040]
DSCW_53750  hypothetical protein [KO:K02040]
DSCW_40950  phosphate ABC transporter substrate-binding protein [KO:K02040]
DSCW_58530  pstC; phosphate transport system permease protein [KO:K02037]
DSCW_40940  phosphate ABC transporter permease [KO:K02037]
DSCW_58540  phosphate transport system permease protein PstA [KO:K02038]
DSCW_40930  phosphate ABC transporter permease [KO:K02038]
DSCW_58550  pstB; phosphate import ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
DSCW_40920  pstB1; phosphate import ATP-binding protein PstB 1 [KO:K02036] [EC:7.3.2.1]
DSCW_27520  gltI; glutamate/aspartate ABC transporter substrate-binding protein [KO:K10001]
DSCW_27540  gltK; glutamate/aspartate transporter permease GltK [KO:K10002]
DSCW_27530  ABC transporter permease [KO:K10003]
DSCW_64070  amino acid ABC transporter substrate-binding protein [KO:K09969]
DSCW_64080  ABC transporter permease [KO:K09970]
DSCW_64090  amino acid ABC transporter permease [KO:K09971]
DSCW_64100  arginine ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
DSCW_64860  argT; ABC transporter substrate-binding protein [KO:K10022]
DSCW_64880  amino acid ABC transporter permease [KO:K10023]
DSCW_64870  histidine/lysine/arginine/ornithine ABC transporter permease HisQ [KO:K10024]
DSCW_64850  histidine/lysine/arginine/ornithine ABC transporter ATP-binding protein HisP [KO:K10025] [EC:7.4.2.1]
DSCW_32950  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_54870  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_31350  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_02060  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_55340  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_09300  ABC transporter substrate-binding protein [KO:K01999]
DSCW_28070  ABC transporter substrate-binding protein [KO:K01999]
DSCW_47160  livK-1; branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_53600  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_43610  ABC transporter substrate-binding protein [KO:K01999]
DSCW_44010  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_45780  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_25050  amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_28090  ABC transporter substrate-binding protein [KO:K01999]
DSCW_32520  ABC transporter substrate-binding protein [KO:K01999]
DSCW_39030  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
DSCW_56320  ABC transporter substrate-binding protein [KO:K01999]
DSCW_46520  lipoprotein [KO:K01999]
DSCW_03210  ABC transporter substrate-binding protein [KO:K01999]
DSCW_54860  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_02070  livH_1; branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_09290  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_47120  livH_2; branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_53590  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_43600  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_43970  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_45800  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_25040  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_39020  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_56310  branched-chain amino acid ABC transporter permease [KO:K01997]
DSCW_47130  livM; branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_53580  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_25030  amino acid ABC transporter permease [KO:K01998]
DSCW_54850  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_43590  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_43980  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_39010  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_56300  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_45790  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_02080  hypothetical protein [KO:K01998]
DSCW_09280  branched-chain amino acid ABC transporter permease [KO:K01998]
DSCW_54840  ABC transporter ATP-binding protein [KO:K01995]
DSCW_02090  livG; ABC transporter ATP-binding protein [KO:K01995]
DSCW_09270  ABC transporter ATP-binding protein [KO:K01995]
DSCW_47140  ABC transporter ATP-binding protein [KO:K01995]
DSCW_53610  ABC transporter ATP-binding protein [KO:K01995]
DSCW_43580  ABC transporter ATP-binding protein [KO:K01995]
DSCW_43990  ABC transporter ATP-binding protein [KO:K01995]
DSCW_45820  ABC transporter ATP-binding protein [KO:K01995]
DSCW_25020  ABC transporter ATP-binding protein [KO:K01995]
DSCW_39000  ABC transporter ATP-binding protein [KO:K01995]
DSCW_56290  ABC transporter ATP-binding protein [KO:K01995]
DSCW_53570  ABC transporter ATP-binding protein [KO:K01996]
DSCW_25010  ABC transporter ATP-binding protein [KO:K01996]
DSCW_54830  livF_2; ABC transporter ATP-binding protein [KO:K01996]
DSCW_43570  high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
DSCW_44000  ABC transporter ATP-binding protein [KO:K01996]
DSCW_38990  ABC transporter ATP-binding protein [KO:K01996]
DSCW_56280  ABC transporter ATP-binding protein [KO:K01996]
DSCW_45770  ABC transporter ATP-binding protein [KO:K01996]
DSCW_02100  livF_1; ABC transporter ATP-binding protein [KO:K01996]
DSCW_09260  ABC transporter ATP-binding protein [KO:K01996]
DSCW_12230  metQ; lipoprotein [KO:K02073]
DSCW_12210  metI2; methionine ABC transporter permease [KO:K02072]
DSCW_12200  metN; methionine import ATP-binding protein MetN [KO:K02071]
DSCW_66150  ABC transporter substrate-binding protein [KO:K13893]
DSCW_66130  microcin C ABC transporter permease YejB [KO:K13894]
DSCW_66140  peptide ABC transporter permease [KO:K13895]
DSCW_42950  cation ABC transporter substrate-binding protein [KO:K09815]
DSCW_42970  membrane protein [KO:K09816]
DSCW_42960  zinc ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
DSCW_43110  cbiM; cobalt transporter CbiM [KO:K02007]
DSCW_43130  cbiQ; cobalt ECF transporter T component CbiQ [KO:K02008]
DSCW_43140  energy-coupling factor ABC transporter ATP-binding protein [KO:K02006]
DSCW_39190  ABC transporter substrate-binding protein [KO:K10094]
DSCW_43100  ATP-dependent DNA ligase [KO:K10094]
DSCW_43120  hypothetical protein [KO:K16915]
DSCW_27480  hypothetical protein [KO:K16915]
DSCW_00220  biotin biosynthesis protein BioY [KO:K03523]
DSCW_00240  energy-coupling factor transporter transmembrane protein EcfT [KO:K16783]
DSCW_00230  ABC transporter ATP-binding protein [KO:K16784] [EC:7.6.2.-]
DSCW_50850  transport permease protein [KO:K09690]
DSCW_50840  ABC transporter [KO:K09691] [EC:7.5.2.14]
DSCW_14260  ABC transporter permease [KO:K09808]
DSCW_13200  ABC transporter permease [KO:K09808]
DSCW_13210  lolD; lipoprotein-releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
DSCW_15050  lptF; LPS export ABC transporter permease LptF [KO:K07091]
DSCW_15040  lptG; LPS export ABC transporter permease LptG [KO:K11720]
DSCW_12650  yhbG; ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
DSCW_41150  ftsX; cell division protein FtsX [KO:K09811]
DSCW_41160  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
DSCW_67230  ABC transporter ATP-binding protein [KO:K11085] [EC:7.5.2.6]
DSCW_17260  multidrug ABC transporter ATP-binding protein [KO:K18889]
DSCW_17270  lipid A ABC transporter permease/ATP-binding protein [KO:K18890]
DSCW_55670  macB; macrolide export ATP-binding/permease protein MacB [KO:K05685] [EC:7.6.2.-]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
LinkDB

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