Entry
Name
ABC transporters - Escherichia coli K-12 DH10B
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Escherichia coli K-12 DH10B [GN:
ecd ]
Gene
ECDH10B_2590 cysP; thiosulfate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02048 ]
ECDH10B_4106 sbp; sulfate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23163 ]
ECDH10B_2589 cysU; sulfate/thiosulfate transporter subunit; membrane component of ABC superfamily [KO:K02046 ]
ECDH10B_2588 cysW; sulfate/thiosulfate transporter subunit; membrane component of ABC superfamily [KO:K02047 ]
ECDH10B_2587 cysA; sulfate/thiosulfate transporter subunit; ATP-binding component of ABC superfamily [KO:K02045 ] [EC:7.3.2.3 ]
ECDH10B_0321 tauA; taurine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15551 ]
ECDH10B_0323 tauC; taurine transporter subunit; membrane component of ABC superfamily [KO:K15552 ]
ECDH10B_1006 ssuA; alkanesulfonate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15553 ]
ECDH10B_1004 ssuC; alkanesulfonate transporter subunit; membrane component of ABC superfamily [KO:K15554 ]
ECDH10B_0831 modA; molybdate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02020 ]
ECDH10B_0832 modB; molybdate transporter subunit; membrane component of ABC superfamily [KO:K02018 ]
ECDH10B_0828 modF; fused molybdate transporter subunits of ABC superfamily: ATP-binding components [KO:K05776 ]
ECDH10B_0249 afuB; CP4-6 prophage; predicted ferric trasnporter subunit; membrane component of ABC superfamily [KO:K02011 ]
ECDH10B_0248 afuC; CP4-6 prophage; predicted ferric transporter subunit; ATP-binding component of ABC superfamily [KO:K02010 ] [EC:7.2.2.7 ]
ECDH10B_1195 potD; polyamine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K11069 ]
ECDH10B_1196 potC; polyamine transporter subunit; membrane component of ABC superfamily [KO:K11070 ]
ECDH10B_1197 potB; polyamine transporter subunit; membrane component of ABC superfamily [KO:K11071 ]
ECDH10B_0924 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
ECDH10B_0927 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
ECDH10B_0926 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
ECDH10B_2845 proX; glycine betaine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02002 ]
ECDH10B_2844 proW; glycine betaine transporter subunit; membrane component of ABC superfamily [KO:K02001 ]
ECDH10B_2287 yehZ; predicted transporter subunit: periplasmic-binding component of ABC superfamily [KO:K05845 ]
ECDH10B_2284 yehW; predicted transporter subunit: membrane component of ABC superfamily [KO:K05846 ]
ECDH10B_2286 yehY; predicted transporter subunit: membrane component of ABC superfamily [KO:K05846 ]
ECDH10B_4223 malE; maltose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10108 ]
ECDH10B_4222 malF; maltose transporter subunit; membrane component of ABC superfamily [KO:K10109 ]
ECDH10B_4221 malG; maltose transporter subunit; membrane component of ABC superfamily [KO:K10110 ]
ECDH10B_4224 malK; fused maltose transport subunit, ATP-binding component of ABC superfamily; regulatory protein [KO:K10111 ] [EC:7.5.2.-]
ECDH10B_2715 yphF; predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23545 ]
ECDH10B_2713 yphD; predicted sugar transporter subunit: membrane component of ABC superfamily [KO:K23546 ]
ECDH10B_2714 yphE; fused predicted sugar transporter subunits of ABC superfamily: ATP-binding components [KO:K23547 ]
ECDH10B_3368 yrbE; predicted toluene transporter subunit: membrane component of ABC superfamily [KO:K02066 ]
ECDH10B_3369 yrbF; predicted toluene transporter subunit: ATP-binding component of ABC superfamily [KO:K02065 ]
ECDH10B_3939 rbsB; D-ribose transporter subunit; periplasmic-binding compoent of ABC superfamily [KO:K10439 ]
ECDH10B_3938 rbsC; D-ribose transporter subunit; membrane component of ABC superfamily [KO:K10440 ]
ECDH10B_2041 araF; periplasmic-binding component of L-arabinose ABC transporter (precursor) [KO:K10537 ]
ECDH10B_2039 araH; subunit of L-arabinose ABC transporter containing membrane components [KO:K10538 ]
ECDH10B_4422 ytfQ; predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23508 ]
ECDH10B_4426 yjfF; predicted sugar transporter subunit: membrane component of ABC superfamily [KO:K23509 ]
ECDH10B_2307 mglB; methyl-galactoside transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10540 ]
ECDH10B_2305 mglC; methyl-galactoside transporter subunit; membrane component of ABC superfamily [KO:K10541 ]
ECDH10B_3747 xylF; D-xylose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10543 ]
ECDH10B_3749 xylH; D-xylose transporter subunit; membrane component of ABC superfamily [KO:K10544 ]
ECDH10B_4279 alsB; D-allose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10549 ]
ECDH10B_4277 alsC; D-allose transporter subunit; membrane component of ABC superfamily [KO:K10550 ]
ECDH10B_3627 ugpB; glycerol-3-phosphate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K05813 ]
ECDH10B_3626 ugpA; glycerol-3-phosphate transporter subunit; membrane component of ABC superfamily [KO:K05814 ]
ECDH10B_3625 ugpE; glycerol-3-phosphate transporter subunit; membrane component of ABC superfamily [KO:K05815 ]
ECDH10B_3915 pstS; phosphate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02040 ]
ECDH10B_3914 pstC; phosphate transporter subunit; membrane component of ABC superfamily [KO:K02037 ]
ECDH10B_3913 pstA; phosphate transporter subunit; membrane component of ABC superfamily [KO:K02038 ]
ECDH10B_4297 phnD; phosphonate/organophosphate ester transporter subunit; periplasmic binding component of ABC superfamily [KO:K02044 ]
ECDH10B_4298 phnC; phosphonate/organophosphate ester transporter subunit; ATP-binding component of ABC superfamily [KO:K02041 ] [EC:7.3.2.2 ]
ECDH10B_2472 argT; lysine/arginine/ornithine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10013 ]
ECDH10B_2469 hisM; histidine/lysine/arginine/ornithine transporter subunit; membrane component of ABC superfamily [KO:K10015 ]
ECDH10B_2470 hisQ; histidine/lysine/arginine/ornithine transporter subunit; membrane component of ABC superfamily [KO:K10016 ]
ECDH10B_2468 hisP; histidine/lysine/arginine/ornithine transporter subunit; ATP-binding component of ABC superfamily [KO:K10017 ] [EC:7.4.2.1 ]
ECDH10B_2471 hisJ; histidine/lysine/arginine/ornithine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10014 ]
ECDH10B_0879 glnH; glutamine transporter subunit; periplasmic binding component of ABC superfamily [KO:K10036 ]
ECDH10B_0878 glnP; glutamine transporter subunit; membrane component of ABC superfamily [KO:K10037 ]
ECDH10B_0930 artJ; arginine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09996 ]
ECDH10B_0933 artI; arginine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09997 ]
ECDH10B_0931 artM; arginine transporter subunit; membrane component of ABC superfamily [KO:K09998 ]
ECDH10B_0932 artQ; arginine transporter subunit; membrane component of ABC superfamily [KO:K09999 ]
ECDH10B_0616 gltI; glutamate and aspartate transporter subunit, periplasmic-binding component of ABC superfamily [KO:K10001 ]
ECDH10B_0724 gltI; glutamate and aspartate transporter subunit, periplasmic-binding component of ABC superfamily [KO:K10001 ]
ECDH10B_0614 gltK; glutamate and aspartate transporter subunit, membrane component of ABC superfamily [KO:K10002 ]
ECDH10B_0722 gltK; glutamate and aspartate transporter subunit, membrane component of ABC superfamily [KO:K10002 ]
ECDH10B_0615 gltJ; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10003 ]
ECDH10B_0723 gltJ; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10003 ]
ECDH10B_0613 gltL; glutamate and aspartate transporter subunit, ATP-binding component of ABC superfamily [KO:K10004 ] [EC:7.4.2.1 ]
ECDH10B_0721 gltL; glutamate and aspartate transporter subunit, ATP-binding component of ABC superfamily [KO:K10004 ] [EC:7.4.2.1 ]
ECDH10B_3443 yhdW; predicted amino-acid transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09969 ]
ECDH10B_3444 yhdX; predicted amino-acid transporter subunit; membrane component of ABC superfamily [KO:K09970 ]
ECDH10B_3445 yhdY; predicted amino-acid transporter subunit; membrane component of ABC superfamily [KO:K09971 ]
ECDH10B_3446 yhdZ; predicted amino-acid transporter subunit; ATP-binding component of ABC superfamily [KO:K09972 ] [EC:7.4.2.1 ]
ECDH10B_2061 fliY; cystine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02424 ]
ECDH10B_2059 yecS; predicted transporter subunit: membrane component of ABC superfamily [KO:K10009 ]
ECDH10B_3632 livK; leucine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K01999 ]
ECDH10B_3634 livJ; leucine/isoleucine/valine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K01999 ]
ECDH10B_3631 livH; leucine/isoleucine/valine transporter subunit; membrane component of ABC superfamily [KO:K01997 ]
ECDH10B_3630 livM; leucine/isoleucine/valine transporter subunit; membrane component of ABC superfamily [KO:K01998 ]
ECDH10B_3629 livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995 ]
ECDH10B_3628 livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996 ]
ECDH10B_0178 metQ; receptor component of DL-methionine uptake transporter (MUT) [KO:K02073 ]
ECDH10B_0179 metI; membrane component of DL-methionine uptake transporter (MUT) [KO:K02072 ]
ECDH10B_0180 metN; ATP-binding component of DL-methionine uptake transporter (MUT) [KO:K02071 ]
ECDH10B_1449 mppA; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15580 ]
ECDH10B_1306 oppB; oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K15581 ]
ECDH10B_1307 oppC; oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K15582 ]
ECDH10B_1308 oppD; oligopeptide transporter subunit; ATP-binding component of ABC superfamily [KO:K15583 ]
ECDH10B_3723 dppA; dipeptide transporter; periplasmic-binding component of ABC superfamily [KO:K12368 ]
ECDH10B_3722 dppB; dipeptide transporter; membrane component of ABC superfamily [KO:K12369 ]
ECDH10B_3721 dppC; dipeptide transporter; membrane component of ABC superfamily [KO:K12370 ]
ECDH10B_3720 dppD; dipeptide transporter; ATP-binding component of ABC superfamily [KO:K12371 ]
ECDH10B_3719 dppF; dipeptide transporter; ATP-binding component of ABC superfamily [KO:K12372 ]
ECDH10B_1411 sapA; predicted antimicrobial peptide transporter subunit; periplasmic-binding component of ABC superfamily [KO:K19226 ]
ECDH10B_1410 sapB; predicted antimicrobial peptide transporter subunit; membrane component of ABC superfamily [KO:K19227 ]
ECDH10B_1409 sapC; predicted antimicrobial peptide transporter subunit; membrane component of ABC superfamily [KO:K19228 ]
ECDH10B_1408 sapD; predicted antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily [KO:K19229 ]
ECDH10B_1407 sapF; predicted antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily [KO:K19230 ]
ECDH10B_3650 nikA; nickel transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15584 ]
ECDH10B_3651 nikB; nickel transporter subunit; membrane component of ABC superfamily [KO:K15585 ]
ECDH10B_3652 nikC; nickel transporter subunit; membrane component of ABC superfamily [KO:K15586 ]
ECDH10B_0899 gsiB; periplasmic solute-binding component of a glutathione transporter [KO:K13889 ]
ECDH10B_2335 yejA; predicted oligopeptide transporter subunit; periplasmic-binding component of ABC superfamily [KO:K13893 ]
ECDH10B_2336 yejB; predicted oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K13894 ]
ECDH10B_2337 yejE; predicted oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K13895 ]
ECDH10B_2338 yejF; fused predicted oligopeptide transporter subunits of ABC superfamilly: ATP-binding components [KO:K13896 ]
ECDH10B_4488 fecB; KpLE2 phage-like element; iron-dicitrate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23181 ]
ECDH10B_4486 fecD; KpLE2 phage-like element; iron-dicitrate transporter subunit; membrane component of ABC superfamily [KO:K23182 ]
ECDH10B_4487 fecC; KpLE2 phage-like element; iron-dicitrate transporter subunit; membrane component of ABC superfamily [KO:K23183 ]
ECDH10B_4485 fecE; KpLE2 phage-like element; iron-dicitrate transporter subunit; ATP-binding component of ABC superfamily [KO:K23184 ] [EC:7.2.2.18 ]
ECDH10B_0552 fepB; iron-enterobactin transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23185 ]
ECDH10B_0660 fepB; iron-enterobactin transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23185 ]
ECDH10B_0550 fepD; membrane component of ABC superfamily iron-enterobactin transporter [KO:K23186 ]
ECDH10B_0658 fepD; membrane component of ABC superfamily iron-enterobactin transporter [KO:K23186 ]
ECDH10B_0549 fepG; iron-enterobactin transporter subunit; membrane component of ABC superfamily [KO:K23187 ]
ECDH10B_0657 fepG; iron-enterobactin transporter subunit; membrane component of ABC superfamily [KO:K23187 ]
ECDH10B_0132 fhuD; iron-hydroxamate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23227 ]
ECDH10B_0133 fhuB; fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components [KO:K23228 ]
ECDH10B_0138 btuF; periplasmic binding component of cobalamin (vitamin B-12) transporter [KO:K06858 ]
ECDH10B_1847 btuC; vitamin B12 transporter subunit: membrane component of ABC superfamily [KO:K06073 ]
ECDH10B_1998 znuA; zinc transporter subunit: periplasmic-binding component of ABC superfamily [KO:K09815 ]
ECDH10B_2000 znuB; zinc transporter subunit: membrane component of ABC superfamily [KO:K09816 ]
ECDH10B_1647 lsrB; AI2 transporter; periplasmic-binding component of ABC superfamily [KO:K10555 ]
ECDH10B_1644 lsrA; fused AI2 transporter subunits of ABC superfamily: ATP-binding components [KO:K10558 ]
ECDH10B_1188 lolC; outer membrane-specific lipoprotein transporter subunit; membrane component of ABC superfamily [KO:K09808 ]
ECDH10B_1190 lolE; outer membrane-specific lipoprotein transporter subunit; membrane component of ABC superfamily [KO:K09808 ]
ECDH10B_1189 lolD; outer membrane-specific lipoprotein transporter subunit; ATP-binding component of ABC superfamily [KO:K09810 ] [EC:7.6.2.-]
ECDH10B_2356 ccmC; heme exporter subunit; membrane component of ABC superfamily [KO:K02195 ]
ECDH10B_2357 ccmB; heme exporter subunit; membrane component of ABC superfamily [KO:K02194 ]
ECDH10B_3636 ftsX; predicted transporter subunit: membrane component of ABC superfamily [KO:K09811 ]
ECDH10B_3637 ftsE; predicted transporter subunit: ATP-binding component of ABC superfamily [KO:K09812 ]
ECDH10B_0984 msbA; fused lipid transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K11085 ] [EC:7.5.2.6 ]
ECDH10B_0404 mdlA; fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components [KO:K18889 ]
ECDH10B_0405 mdlB; fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components [KO:K18890 ]
ECDH10B_0956 cydC; fused cysteine transporter subunits of ABC superfamily; membrane component and ATP-binding component [KO:K16012 ]
ECDH10B_0957 cydD; fused cysteine transporter subunits of ABC superfamily; membrane component and ATP-binding component [KO:K16013 ]
ECDH10B_0949 macB; fused macrolide transporter subunits of ABC superfamily: ATP-binding component; membrane component [KO:K05685 ] [EC:7.6.2.-]
ECDH10B_2368 yojI; fused predicted multidrug transport subunits of ABC superfamily: membrane component; ATP-binding component [KO:K06159 ]
ECDH10B_1627 yddA; fused predicted multidrug transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
LinkDB
All DBs