KEGG PATHWAY: efe00740

KEGG

PATHWAY: efe00740

Entry

efe00740                    Pathway

Name

Riboflavin metabolism - Escherichia fergusonii

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Riboflavin metabolism

Module

Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:efe00740]

Other DBs

GO:

Organism

Escherichia fergusonii [GN:efe]

Gene

ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]

ribD; fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]

ybjI; putative phosphatase [KO:K20861] [EC:3.1.3.102 3.1.3.104]

yigB; putative hydrolase [KO:K20862] [EC:3.1.3.102 3.1.3.104]

ribB; 3,4-dihydroxy-2-butanone-4-phosphate synthase [KO:K02858] [EC:4.1.99.12]

ribE; riboflavin synthase beta chain [KO:K00794] [EC:2.5.1.78]

ribC; riboflavin synthase, alpha subunit [KO:K00793] [EC:2.5.1.9]

ribF; bifunctional riboflavin kinase and FAD synthetase [KO:K11753] [EC:2.7.1.26 2.7.7.2]

Periplasmic appA protein precursor [Includes: Phosphoanhydride phosphohydrolase (pH 2.5 acid phosphatase) (AP); 4-phytase] [KO:K01093] [EC:3.1.3.26 3.1.3.2]

aphA; acid phosphatase/phosphotransferase, class B, non-specific [KO:K03788] [EC:3.1.3.2]

hpaC; 4-hydroxyphenylacetate 3-monooxygenase small component, Flavin:NADH reductase [KO:K00484] [EC:1.5.1.36]

fre; flavin reductase [KO:K05368] [EC:1.5.1.41]

ssuE; NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]

Hydroxyethylthiazole kinase (4-methyl-5-beta-hydroxyethylthiazole kinase) (Thz kinase) (TH kinase) [KO:K00878] [EC:2.7.1.50]

nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]

ymfB; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase [KO:K12152] [EC:3.6.1.-]

ubiX; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase [KO:K03186] [EC:2.5.1.129]

conserved putative non-oxidative reversible hydroxyarylic acid decarboxylase [KO:K03186] [EC:2.5.1.129]

Compound

FAD

GTP

FMN

D-Ribulose 5-phosphate

Dimethylallyl diphosphate

Riboflavin

Ribitol

Reduced riboflavin

5-Amino-6-(5'-phosphoribosylamino)uracil

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

FADH2

Prenol

Lumichrome

Reduced FMN

Dimethylbenzimidazole

6,7-Dimethyl-8-(D-ribityl)lumazine

5-Amino-6-(5'-phospho-D-ribitylamino)uracil

5-Amino-6-(1-D-ribitylamino)uracil

7-Hydroxy-6-methyl-8-ribityllumazine

L-3,4-Dihydroxybutan-2-one 4-phosphate

2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one

Dimethylallyl phosphate

Prenylated FMNH2

Reference

Authors

Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.

Title

Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.

Journal

Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141

Reference

Authors

Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.

Title

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.

Journal

Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x

Reference

Authors

Haase I, Fischer M, Bacher A, Schramek N.

Title

Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.

Journal

J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200

Reference

Authors

Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.

Title

Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.

Journal

Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780

Related
pathway

Pentose phosphate pathway

Pentose and glucuronate interconversions

Purine metabolism

Porphyrin metabolism

Terpenoid backbone biosynthesis

KO pathway

LinkDB

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