KEGG   PATHWAY: ko00740
Entry
ko00740                     Pathway                                
Name
Riboflavin metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00740  Riboflavin metabolism
ko00740

Module
M00125  Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:ko00740]
M00911  Riboflavin biosynthesis, fungi, GTP => riboflavin/FMN/FAD [PATH:ko00740]
Other DBs
GO: 0006771
Orthology
K00082  ribD2; 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193]
K00299  ssuE, msuE; FMN reductase [EC:1.5.1.38]
K00484  hpaC; flavin reductase (NADH) [EC:1.5.1.36]
K00793  ribE, RIB5; riboflavin synthase [EC:2.5.1.9]
K00794  ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
K00861  RFK, FMN1; riboflavin kinase [EC:2.7.1.26]
K00878  thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]
K00953  FLAD1; FAD synthetase [EC:2.7.7.2]
K01078  PHO; acid phosphatase [EC:3.1.3.2]
K01093  appA; 4-phytase / acid phosphatase [EC:3.1.3.26 3.1.3.2]
K01497  ribA, RIB1; GTP cyclohydrolase II [EC:3.5.4.25]
K01498  ribD1; diaminohydroxyphosphoribosylaminopyrimidine deaminase [EC:3.5.4.26]
K01513  ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K01515  nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
K02858  ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]
K03186  ubiX, bsdB, PAD1; flavin prenyltransferase [EC:2.5.1.129]
K03788  aphA; acid phosphatase (class B) [EC:3.1.3.2]
K04719  bluB; 5,6-dimethylbenzimidazole synthase [EC:1.13.11.79]
K05368  fre, ubiB; NAD(P)H-flavin reductase [EC:1.5.1.41]
K05901  BLVRB; biliverdin reductase / flavin reductase [EC:1.3.1.24 1.5.1.30]
K07732  rfk; riboflavin kinase, archaea type [EC:2.7.1.161]
K08096  gch3; GTP cyclohydrolase IIa [EC:3.5.4.29]
K09474  phoN; acid phosphatase (class A) [EC:3.1.3.2]
K11752  ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
K11753  ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]
K12152  nudJ; phosphatase NudJ [EC:3.6.1.-]
K14379  ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K14394  ACP1; low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48]
K14410  ACP2; lysosomal acid phosphatase [EC:3.1.3.2]
K14652  ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
K14653  arfB; 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC:3.5.1.102]
K14654  RIB7, arfC; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302]
K14655  RIB2, PUS8; tRNA pseudouridine32 synthase / 2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [EC:5.4.99.28]
K14656  ribL; FAD synthetase [EC:2.7.7.2]
K15245  tftC, tcpX; flavin reductase [EC:1.5.1.37]
K16902  E1.5.1.45; FAD reductase [NAD(P)H] [EC:1.5.1.45]
K18453  NUDT23; ADP-ribose/FAD diphosphatase [EC:3.6.1.13 3.6.1.18]
K19285  nfrA1; FMN reductase (NADPH) [EC:1.5.1.38]
K19286  nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39]
K20146  ntaB, nmoB; nitrilotriacetate monooxygenase reductase component [EC:1.5.1.42]
K20860  FHY1; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104]
K20861  ybjI; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104]
K20862  yigB; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104]
K20884  FHY; riboflavin kinase / FMN hydrolase [EC:2.7.1.26 3.1.3.102]
K21063  K21063; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K21064  ycsE, yitU, ywtE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K22393  nfr1; flavin reductase (NADH) subunit 1 [EC:1.5.1.36]
K22394  nfr2; flavin reductase (NADH) subunit 2 [EC:1.5.1.36]
K22912  PYRP2; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K22949  RIBF; FAD synthetase
K23458  PHO5_11_12; repressible acid phosphatase
K23462  tgnA; flavin-dependent trigonelline monooxygenase, reductase component
K23470  C1-hpah; 4-hydroxyphenylacetate 3-hydroxylase, reductase component
K25520  E3.6.1.76; prenyl-diphosphate phosphatase
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00235  Dimethylallyl diphosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01390  Prenol
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
C21214  Dimethylallyl phosphate
C21215  Prenylated FMNH2
Reference
PMID:12136096
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
PMID:11856310
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
PMID:12867427
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
PMID:16042598
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
ko00030  Pentose phosphate pathway
ko00040  Pentose and glucuronate interconversions
ko00230  Purine metabolism
ko00860  Porphyrin metabolism
ko00900  Terpenoid backbone biosynthesis

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