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Entry Name O-Antigen nucleotide sugar biosynthesis - Parafrankia sp. EAN1pec
Description The O-antigen is a repetitive glycan polymer with a repeat unit of two to six sugar residues, and comprises the outermost and immunogenic domain of the lipopolysaccharide (
map00540 ). Most of the sugar residues are derived from nucleotide sugars and the genes for their biosynthesis seem to be well conserved among Gram-negative bacterial species. They include UDP-sugars synthesized from Glc-1P via UDP-Glc or from GlcNAc-1P via UDP-GlcNAc, GDP-sugars synthesized from Fru-6P via GDP-Man, and dTDP-sugars and CDP-sugars synthesized from Glc-1P via dTDP-Glc and CDP-Glc, respectively. CMP-sugars are also synthesized from UDP-GlcNAc. The O-antigen nucleotide sugar biosynthesis genes often form gene clusters with glycosyltransferase genes and other processing genes such as for translocation and polymerization.
Class Metabolism; Glycan biosynthesis and metabolismBRITE hierarchy
Pathway map fre00541 O-Antigen nucleotide sugar biosynthesis
Ortholog table Module Organism Parafrankia sp. EAN1pec [GN:
fre ]
Gene Compound C00043 UDP-N-acetyl-alpha-D-glucosamine
C00128 CMP-N-acetylneuraminate
C00203 UDP-N-acetyl-D-galactosamine
C00688 dTDP-4-dehydro-beta-L-rhamnose
C01170 UDP-N-acetyl-D-mannosamine
C01219 CDP-4-dehydro-6-deoxy-D-glucose
C01222 GDP-4-dehydro-6-deoxy-D-mannose
C03187 dTDP-6-deoxy-beta-L-talose
C03598 CDP-3,6-dideoxy-D-glucose
C03599 CDP-3,6-dideoxy-D-mannose
C03733 UDP-alpha-D-galactofuranose
C04268 dTDP-4-amino-4,6-dideoxy-D-glucose
C04297 CDP-4-dehydro-3,6-dideoxy-D-glucose
C04346 dTDP-4-amino-4,6-dideoxy-D-galactose
C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613 UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C06018 dTDP-4-acetamido-4,6-dideoxy-D-glucose
C06240 UDP-N-acetyl-D-mannosaminouronate
C11907 dTDP-4-oxo-6-deoxy-D-glucose
C11908 3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11925 dTDP-3-amino-3,6-dideoxy-D-glucose
C13952 UDP-N-acetyl-D-galactosaminuronic acid
C17326 CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C19725 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19823 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19947 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose
C19960 dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose
C19961 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972 2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20156 dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose
C20359 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395 UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20415 dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
C20612 GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose
C20638 GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672 GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20682 dTDP-alpha-D-fucofuranose
C20768 UDP-2-acetamido-2,6-dideoxy-beta-L-talose
C20769 UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-4-hexulose
C20774 UDP-N-acetyl-beta-L-fucosamine
C22245 UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide
C22246 UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic acid
C22247 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucopyranose
C22248 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose
C22249 2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose
C22250 5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid
C22251 CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic acid
C22252 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose
C22253 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose
C22254 2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose
C22255 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22256 CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22257 dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose
C22259 UDP-2-acetamido-2,6-dideoxy-beta-L-mannose
C22260 UDP-2-acetamido-2,6-dideoxy-beta-L-glucose
C22261 UDP-2-acetamido-2,6-dideoxy-alpha-D-galactose
C22262 UDP-2-acetamido-2,6-dideoxy-alpha-D-glucose
C22270 UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose
C22276 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine
C22397 GDP-N-formyl-alpha-D-perosamine
C22575 UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-galactose
C22576 UDP-2-acetamido-2-deoxy-L-altruronic acid
Reference Authors Samuel G, Reeves P
Title Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly.
Journal Reference Authors Burrows LL, Charter DF, Lam JS
Title Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster.
Journal Reference Authors Belanger M, Burrows LL, Lam JS
Title Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
Journal Reference Authors Dean CR, Goldberg JB
Title The wbpM gene in Pseudomonas aeruginosa serogroup O17 resides on a cryptic copy of the serogroup O11 O antigen gene locus.
Journal Reference Authors Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L
Title Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.
Journal Reference Authors Westman EL, Preston A, Field RA, Lam JS
Title Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters.
Journal Reference Authors King JD, Kocincova D, Westman EL, Lam JS
Title Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa.
Journal Reference Authors Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA
Title Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid.
Journal Reference Authors Hwang S, Aronov A, Bar-Peled M
Title The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579.
Journal Reference Authors McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyd EF
Title Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide.
Journal Related fre00520 Amino sugar and nucleotide sugar metabolism
KO pathway LinkDB All DBs
