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Entry
Name
Biosynthesis of various nucleotide sugars
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
ko00541 Biosynthesis of various nucleotide sugars
Module
M00063 CMP-3-deoxy-D-manno-octulosonate biosynthesis, ribulose-5P => CMP-KDO [PATH:ko00541 ]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis, sedoheptulose-7P => ADP-LDmanHep [PATH:ko00541 ]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:ko00541 ]
M00793 dTDP-L-rhamnose biosynthesis, glucose-1P => dTDP-L-Rha [PATH:ko00541 ]
M00922 CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac [PATH:ko00541 ]
M00923 UDP-L-FucNAm biosynthesis, UDP-GlcNAc => UDP-L-FucNAm [PATH:ko00541 ]
M00955 CMP-Neu5Ac/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc [PATH:ko00541 ]
Orthology
K00523 ascD, ddhD, rfbI; CDP-4-dehydro-6-deoxyglucose reductase, E3 [EC:1.17.1.1 ]
K00607 wbkC; GDP-perosamine N-formyltransferase
K00963 UGP2, galU, galF; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9 ]
K00971 manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13 ]
K00973 rfbA, rmlA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24 ]
K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38 ]
K00983 neuA, nnaC; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43 ]
K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55 ]
K01639 E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3 ]
K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14 ]
K02472 wecC; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.336 ]
K02473 wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.7 5.1.3.45 ]
K02474 wbpO; UDP-N-acetyl-D-glucosamine/UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.136 1.1.1.-]
K02805 wecE, rffA; dTDP-4-amino-4,6-dideoxygalactose transaminase [EC:2.6.1.59 ]
K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45 ]
K03271 gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28 ]
K03272 gmhC, hldE, waaE, rfaE; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70 ]
K03274 gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20 ]
K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157 ]
K07031 hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168 ]
K07806 arnB, pmrH; UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87 ]
K08068 siaA, neuC1; UDP-N-acetylglucosamine 2-epimerase (hydrolysing) [EC:3.2.1.183 ]
K10011 arnA, pmrI; UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) [EC:2.1.2.13 1.1.1.305 ]
K10012 arnC, pmrF; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [EC:2.4.2.53 ]
K12451 UER1; 3,5-epimerase/4-reductase [EC:5.1.3.- 1.1.1.-]
K12452 ascC, ddhC, rfbH; CDP-4-dehydro-6-deoxyglucose reductase, E1 [EC:1.17.1.1 ]
K13014 arnD; undecaprenyl phosphate-alpha-L-ara4FN deformylase [EC:3.5.1.-]
K13016 wbpB; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335 ]
K13017 wbpE, wlbC; UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98 ]
K13018 wbpD, wlbB; UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase [EC:2.3.1.201 ]
K13020 wlbA, bplA; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335 ]
K13967 nanEK; N-acetylmannosamine-6-phosphate 2-epimerase / N-acetylmannosamine kinase [EC:5.1.3.9 2.7.1.60 ]
K15669 hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71 ]
K15857 ascE; CDP-3, 6-dideoxy-D-glycero-D-glycero-4-hexulose-5-epimerase [EC:5.1.-.-]
K15858 ascF; CDP-3, 6-dideoxy-D-glycero-L-glycero-4-hexulose-4-reductase [EC:1.1.1.-]
K15894 pseB, wbjB; UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase [EC:4.2.1.115 5.1.3.-]
K15895 pseC; UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine transaminase [EC:2.6.1.92 ]
K15896 pseH; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase [EC:2.3.1.202 ]
K15897 pseG; UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase [EC:3.6.1.57 ]
K16011 algA, xanB, rfbA, wbpW, pslB; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8 ]
K16704 rffC, wecD; dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase [EC:2.3.1.210 ]
K18429 legG, neuC2; GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) [EC:3.2.1.184 ]
K18431 legF, ptmB; CMP-N,N'-diacetyllegionaminic acid synthase [EC:2.7.7.82 ]
K19068 wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367 ]
K20429 vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33 ]
K20679 fdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.3 ]
K20680 fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase [EC:2.6.1.90 ]
K20681 fdtC; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase [EC:2.3.1.197 ]
K21055 E3.1.3.103; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase [EC:3.1.3.103 ]
K21131 colD; GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase [EC:4.2.1.168 ]
K21279 E2.5.1.132; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase [EC:2.5.1.132 ]
K21344 rfaE1; D-glycero-beta-D-manno-heptose-7-phosphate kinase [EC:2.7.1.167 ]
K21345 rfaE2; D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase [EC:2.7.7.70 ]
K21379 vioB; dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase [EC:2.3.1.209 ]
K21749 CMAS; N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase [EC:2.7.7.43 2.7.7.92 ]
K21750 E2.7.7.92; 3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase [EC:2.7.7.92 ]
K22920 UGP3; UTP---glucose-1-phosphate uridylyltransferase
K22925 tviC, vipB; UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
K22926 tviB, vipA; UDP-N-acetylglucosamine 6-dehydrogenase
K23144 K23144 ; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
K23987 rfbCD, rmlCD; dTDP-4-dehydrorhamnose 3,5-epimerase/reductase
K24249 qdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
K24250 qdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
K24251 qdtC; dTDP-D-Quip3N acetylase
K24252 wbvR, qnlA; UDP-6-deoxy-4-keto-L-IdoNAc 3-epimerase / UDP-4-keto-L-RhaNAc 4-reductase
K24256 wbvD, qnlB; UDP-L-QuiNAc synthase
K24257 neuC, nnaA; UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
K24258 wbjD; UDP-N-acetyl-L-fucosamine synthase
K24259 wbuX; putative aminotransferase
K24280 elg2; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine transaminase
K24281 elg5; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine acetyltransferase
K24282 elg3; UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose 2-epimerase
K24283 elg6; UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulopyranose hydrolase
K24284 elg4; 2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose transferase
K24285 elg7; N,N'-diacetyl-8-epilegionaminate cytidylyltransferase
K24300 wbpM, wbgZ, aatA; UDP-N-acetylglucosamine 4,6-dehydratase
K24301 lea1; UDP-N-acetylglucosamine 4,6-dehydratase
K24302 lea2; UDP-N-acetylbacillosamine transaminase
K24303 lea3; UDP-N-acetylbacillosamine alanyltransferase
K24304 lea5; UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose 2-epimerase
K24305 lea6; UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose hydrolase
K24306 lea4; 2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose transferase
K24307 lea7; 5-N-acetyl-7-N-(D-alanyl)-legionaminic acid cytidylyltransferase
K24310 wbpV, wreQ; UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase
K24311 preQ; UDP-4-keto-6-deoxy-GlcNAc-4-reductase
K24312 wbpK; UDP-4-keto-D-FucNAc 4-reductase
K24327 wbpS; glutamine-dependent amidotransferase
K24336 elg1, pglF; UDP-N-acetylglucosamine 4,6-dehydratase
K25626 aatB, pat, wcfR; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine / UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose transaminase
K26217 wbgX; UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase
K26218 wbgV; UDP-GalNAcA 5-epimerase
K27853 wcaG; UDP-N-acetyl-alpha-D-glucosaminuronate decarboxylase
K27969 pyl; UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactose:2-oxoglutarate ligase
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00128 CMP-N-acetylneuraminate
C00203 UDP-N-acetyl-D-galactosamine
C00688 dTDP-4-dehydro-beta-L-rhamnose
C01112 D-Arabinose 5-phosphate
C01170 UDP-N-acetyl-D-mannosamine
C01187 3-Deoxy-D-manno-octulosonate
C01219 CDP-4-dehydro-6-deoxy-D-glucose
C01222 GDP-4-dehydro-6-deoxy-D-mannose
C03187 dTDP-6-deoxy-beta-L-talose
C03410 N-Glycoloyl-neuraminate
C03598 CDP-3,6-dideoxy-D-glucose
C03599 CDP-3,6-dideoxy-D-mannose
C03691 CMP-N-glycoloylneuraminate
C04089 UDP-4-dehydro-6-deoxy-D-glucose
C04121 CMP-3-deoxy-D-manno-octulosonate
C04257 N-Acetyl-D-mannosamine 6-phosphate
C04268 dTDP-4-amino-4,6-dideoxy-D-glucose
C04297 CDP-4-dehydro-3,6-dideoxy-D-glucose
C04346 dTDP-4-amino-4,6-dideoxy-D-galactose
C04478 3-Deoxy-D-manno-octulosonate 8-phosphate
C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613 UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C05382 Sedoheptulose 7-phosphate
C06018 dTDP-4-acetamido-4,6-dideoxy-D-glucose
C06240 UDP-N-acetyl-D-mannosaminouronate
C06241 N-Acetylneuraminate 9-phosphate
C06397 ADP-D-glycero-beta-D-manno-heptose
C06398 ADP-L-glycero-beta-D-manno-heptose
C07836 D-glycero-beta-D-manno-Heptose 7-phosphate
C07838 D-glycero-beta-D-manno-Heptose 1-phosphate
C11472 D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C11907 dTDP-4-oxo-6-deoxy-D-glucose
C11908 3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11925 dTDP-3-amino-3,6-dideoxy-D-glucose
C13952 UDP-N-acetyl-D-galactosaminuronic acid
C16156 Undecaprenyl phosphate alpha-L-Ara4FN
C16157 Undecaprenyl phosphate alpha-L-Ara4N
C17326 CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C19725 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19823 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19878 D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879 D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880 D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881 GDP-D-glycero-alpha-D-manno-heptose
C19947 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose
C19960 dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose
C19961 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972 2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20156 dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose
C20357 UDP-N,N'-diacetylbacillosamine
C20359 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395 UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20415 dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
C20418 N,N'-Diacetyllegionaminate
C20419 CMP-N,N'-diacetyllegionaminate
C20424 2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20612 GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose
C20638 GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672 GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20682 dTDP-alpha-D-fucofuranose
C20768 UDP-2-acetamido-2,6-dideoxy-beta-L-talose
C20769 UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-4-hexulose
C20774 UDP-N-acetyl-beta-L-fucosamine
C20934 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21383 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384 CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22245 UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide
C22246 UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic acid
C22247 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucopyranose
C22248 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose
C22249 2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose
C22250 5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid
C22251 CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic acid
C22252 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose
C22253 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose
C22254 2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose
C22255 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22256 CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22257 dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose
C22259 UDP-2-acetamido-2,6-dideoxy-beta-L-mannose
C22260 UDP-2-acetamido-2,6-dideoxy-beta-L-glucose
C22261 UDP-2-acetamido-2,6-dideoxy-alpha-D-galactose
C22262 UDP-2-acetamido-2,6-dideoxy-alpha-D-glucose
C22270 UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose
C22276 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine
C22397 GDP-N-formyl-alpha-D-perosamine
C22575 UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-galactose
C22576 UDP-2-acetamido-2-deoxy-L-altruronic acid
C22938 UDP-N-acetyl-alpha-D-xylosamine
Reference
Authors
Samuel G, Reeves P
Title
Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly.
Journal
Reference
Authors
Burrows LL, Charter DF, Lam JS
Title
Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster.
Journal
Reference
Authors
Belanger M, Burrows LL, Lam JS
Title
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
Journal
Reference
Authors
Dean CR, Goldberg JB
Title
The wbpM gene in Pseudomonas aeruginosa serogroup O17 resides on a cryptic copy of the serogroup O11 O antigen gene locus.
Journal
Reference
Authors
Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L
Title
Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.
Journal
Reference
Authors
Westman EL, Preston A, Field RA, Lam JS
Title
Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters.
Journal
Reference
Authors
King JD, Kocincova D, Westman EL, Lam JS
Title
Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa.
Journal
Reference
Authors
Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA
Title
Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid.
Journal
Reference
Authors
Hwang S, Aronov A, Bar-Peled M
Title
The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579.
Journal
Reference
Authors
McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyd EF
Title
Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide.
Journal
Related pathway
ko00051 Fructose and mannose metabolism
ko00520 Amino sugar and nucleotide sugar metabolism
ko00540 Lipopolysaccharide biosynthesis