KEGG   PATHWAY: hyc02010
Entry
hyc02010                    Pathway                                
Name
ABC transporters - Hydrogenophaga sp. PAMC20947
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
hyc02010  ABC transporters
hyc02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Hydrogenophaga sp. PAMC20947 [GN:hyc]
Gene
E5678_09490  nitrate ABC transporter substrate-binding protein [KO:K15576]
E5678_09495  ABC transporter permease [KO:K15577]
E5678_09500  ATP-binding cassette domain-containing protein [KO:K15578] [EC:7.3.2.4]
E5678_19390  transporter substrate-binding domain-containing protein [KO:K15553]
E5678_19380  ABC transporter permease [KO:K15554]
E5678_19385  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
E5678_01635  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
E5678_00590  ABC transporter substrate-binding protein [KO:K02020]
E5678_08780  ABC transporter substrate-binding protein [KO:K02020]
E5678_01630  modB; molybdate ABC transporter permease subunit [KO:K02018]
E5678_01625  modC; molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
E5678_08590  extracellular solute-binding protein [KO:K02012]
E5678_20945  iron ABC transporter permease [KO:K02011]
E5678_20940  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
E5678_09035  thiamine ABC transporter substrate-binding protein [KO:K02064]
E5678_09030  iron ABC transporter permease [KO:K02063]
E5678_09025  ABC transporter ATP-binding protein [KO:K02062] [EC:7.6.2.15]
E5678_19175  extracellular solute-binding protein [KO:K11069]
E5678_19190  ABC transporter permease [KO:K11070]
E5678_19185  ABC transporter permease [KO:K11071]
E5678_19180  ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
E5678_17045  extracellular solute-binding protein [KO:K11073]
E5678_17105  extracellular solute-binding protein [KO:K11073]
E5678_17030  ABC transporter permease subunit [KO:K11074]
E5678_17035  ABC transporter permease subunit [KO:K11075]
E5678_17040  ABC transporter ATP-binding protein [KO:K11076] [EC:7.6.2.16]
E5678_02325  choline ABC transporter substrate-binding protein [KO:K02002]
E5678_02920  ABC transporter substrate-binding protein [KO:K02002]
E5678_02320  choW; choline ABC transporter permease subunit [KO:K02001]
E5678_02925  proline/glycine betaine ABC transporter permease [KO:K02001]
E5678_02315  choV; choline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
E5678_02930  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
E5678_13240  ABC transporter substrate-binding protein [KO:K05845]
E5678_13225  ABC transporter permease [KO:K05846]
E5678_13235  ABC transporter permease [KO:K05846]
E5678_13230  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
E5678_08095  ABC transporter ATP-binding protein [KO:K10111] [EC:7.5.2.-]
E5678_13700  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
E5678_08080  sugar ABC transporter substrate-binding protein [KO:K10227]
E5678_08085  sugar ABC transporter permease [KO:K10228]
E5678_08090  carbohydrate ABC transporter permease [KO:K10229]
E5678_12250  ABC transporter substrate-binding protein [KO:K07323]
E5678_12260  mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
E5678_04130  MCE family protein [KO:K02067]
E5678_07860  mammalian cell entry protein [KO:K02067]
E5678_12265  mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066]
E5678_04140  ABC transporter permease [KO:K02066]
E5678_07865  ABC transporter permease [KO:K02066]
E5678_12245  STAS domain-containing protein [KO:K07122]
E5678_12270  ATP-binding cassette domain-containing protein [KO:K02065]
E5678_04135  ATP-binding cassette domain-containing protein [KO:K02065]
E5678_00460  BMP family ABC transporter substrate-binding protein [KO:K07335]
E5678_11140  BMP family ABC transporter substrate-binding protein [KO:K07335]
E5678_00450  ABC transporter permease [KO:K23535]
E5678_00455  ABC transporter permease [KO:K23536]
E5678_00445  ABC transporter ATP-binding protein [KO:K23537]
E5678_13715  carbohydrate ABC transporter substrate-binding protein [KO:K17315]
E5678_13710  sugar ABC transporter permease [KO:K17316]
E5678_13705  carbohydrate ABC transporter permease [KO:K17317]
E5678_14465  carbohydrate ABC transporter substrate-binding protein [KO:K17321]
E5678_14480  sugar ABC transporter permease [KO:K17322]
E5678_14475  carbohydrate ABC transporter permease [KO:K17323]
E5678_14490  ABC transporter ATP-binding protein [KO:K17324]
E5678_14485  ABC transporter ATP-binding protein [KO:K17325]
E5678_11935  ugpB; sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB [KO:K05813]
E5678_11940  ugpA; sn-glycerol-3-phosphate ABC transporter permease UgpA [KO:K05814]
E5678_11945  ugpE; sn-glycerol-3-phosphate ABC transporter permease UgpE [KO:K05815]
E5678_11950  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K05816] [EC:7.6.2.10]
E5678_14930  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
E5678_06230  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
E5678_06225  pstC; phosphate ABC transporter permease subunit PstC [KO:K02037]
E5678_06220  pstA; phosphate ABC transporter permease PstA [KO:K02038]
E5678_06215  pstB; phosphate ABC transporter ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
E5678_22005  phnD; phosphonate ABC transporter substrate-binding protein [KO:K02044]
E5678_11560  putative selenate ABC transporter substrate-binding protein [KO:K02044]
E5678_22010  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
E5678_11570  ABC transporter permease [KO:K02042]
E5678_11575  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
E5678_22000  phnC; phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
E5678_11565  ATP-binding cassette domain-containing protein [KO:K02041] [EC:7.3.2.2]
E5678_08335  amino acid ABC transporter substrate-binding protein [KO:K09969]
E5678_08340  ABC transporter permease subunit [KO:K09970]
E5678_08345  amino acid ABC transporter permease [KO:K09971]
E5678_08350  amino acid ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
E5678_08640  tcyJ; cystine ABC transporter substrate-binding protein [KO:K02424]
E5678_08645  tcyL; cystine ABC transporter permease [KO:K10009]
E5678_08650  yecC; L-cystine ABC transporter ATP-binding protein YecC [KO:K10010] [EC:7.4.2.1]
E5678_05610  transporter substrate-binding domain-containing protein [KO:K10022]
E5678_05600  ABC transporter permease subunit [KO:K10023]
E5678_05605  ABC transporter permease subunit [KO:K10024]
E5678_05590  ATP-binding cassette domain-containing protein [KO:K10025] [EC:7.4.2.1]
E5678_19640  ABC transporter permease [KO:K01999]
E5678_19870  ABC transporter substrate-binding protein [KO:K01999]
E5678_02860  ABC transporter permease [KO:K01999]
E5678_03390  amino acid ABC transporter substrate-binding protein [KO:K01999]
E5678_04265  ABC transporter permease [KO:K01999]
E5678_05130  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
E5678_09385  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
E5678_10890  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
E5678_10895  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
E5678_11015  ethanolamine utilization protein EutJ [KO:K01999]
E5678_19650  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_19865  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_21755  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_02880  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_04260  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_10885  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_11035  branched-chain amino acid ABC transporter permease [KO:K01997]
E5678_02885  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_04255  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_10880  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_11030  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_19645  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_19860  branched-chain amino acid ABC transporter permease [KO:K01998]
E5678_21760  ABC transporter ATP-binding protein [KO:K01998]
E5678_19655  ABC transporter ATP-binding protein [KO:K01995]
E5678_19880  ABC transporter ATP-binding protein [KO:K01995]
E5678_21765  ABC transporter ATP-binding protein [KO:K01995]
E5678_02870  ABC transporter ATP-binding protein [KO:K01995]
E5678_04250  ABC transporter ATP-binding protein [KO:K01995]
E5678_10875  ABC transporter ATP-binding protein [KO:K01995]
E5678_11025  ABC transporter ATP-binding protein [KO:K01995]
E5678_02875  ABC transporter ATP-binding protein [KO:K01996]
E5678_04245  ABC transporter ATP-binding protein [KO:K01996]
E5678_10870  ABC transporter ATP-binding protein [KO:K01996]
E5678_11020  ABC transporter ATP-binding protein [KO:K01996]
E5678_19635  ABC transporter ATP-binding protein [KO:K01996]
E5678_19875  ABC transporter ATP-binding protein [KO:K01996]
E5678_21770  ABC transporter ATP-binding protein [KO:K01996]
E5678_16610  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
E5678_22075  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
E5678_16605  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
E5678_22080  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
E5678_16600  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
E5678_22085  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
E5678_16595  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
E5678_22090  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
E5678_16590  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
E5678_22095  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
E5678_09245  ABC transporter substrate-binding protein [KO:K12368]
E5678_09240  ABC transporter permease subunit [KO:K12369]
E5678_09235  ABC transporter permease subunit [KO:K12370]
E5678_09230  ATP-binding cassette domain-containing protein [KO:K12371]
E5678_09225  dipeptide ABC transporter ATP-binding protein [KO:K12372]
E5678_05315  ABC transporter substrate-binding protein [KO:K13893]
E5678_05320  ABC transporter permease subunit [KO:K13894]
E5678_05325  ABC transporter permease [KO:K13895]
E5678_05330  ABC transporter ATP-binding protein [KO:K13896]
E5678_10025  ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
E5678_19755  nodulation protein NodJ [KO:K09694]
E5678_19760  ATP-binding cassette domain-containing protein [KO:K09695]
E5678_21575  lipoprotein-releasing ABC transporter permease subunit [KO:K09808]
E5678_21580  lipoprotein-releasing ABC transporter permease subunit [KO:K09808]
E5678_16860  ABC transporter permease [KO:K09808]
E5678_21590  lolD; lipoprotein-releasing ABC transporter ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
E5678_16855  ABC transporter ATP-binding protein [KO:K09810] [EC:7.6.2.-]
E5678_06505  ccmD; heme exporter protein CcmD [KO:K02196]
E5678_06510  heme ABC transporter permease [KO:K02195]
E5678_06515  ccmB; heme exporter protein CcmB [KO:K02194]
E5678_06520  ccmA; cytochrome c biogenesis heme-transporting ATPase CcmA [KO:K02193] [EC:7.6.2.5]
E5678_05115  lptF; LPS export ABC transporter permease LptF [KO:K07091]
E5678_05110  lptG; LPS export ABC transporter permease LptG [KO:K11720]
E5678_15795  lptB; LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
E5678_04460  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
E5678_03285  type I secretion system permease/ATPase [KO:K11004]
E5678_02285  peptidase domain-containing ABC transporter [KO:K13409]
E5678_20295  ABC transporter ATP-binding protein/permease [KO:K24821]
E5678_12575  ABC transporter ATP-binding protein/permease [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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