KEGG   PATHWAY: kng03060
Entry
kng03060                    Pathway                                
Name
Protein export - Huiozyma naganishii
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
kng03060  Protein export
kng03060

Other DBs
GO: 0043952 0043953
Organism
Huiozyma naganishii [GN:kng]
Gene
KNAG_0G01700  KNAG0G01700; hypothetical protein [KO:K03217]
KNAG_0B01290  KNAG0B01290; hypothetical protein [KO:K03106] [EC:3.6.5.4]
KNAG_0C01660  KNAG0C01660; hypothetical protein [KO:K10956]
KNAG_0B05970  KNAG0B05970; hypothetical protein [KO:K10956]
KNAG_0C03680  KNAG0C03680; hypothetical protein [KO:K09481]
KNAG_0H02920  KNAG0H02920; hypothetical protein [KO:K07342]
KNAG_0A01790  KNAG0A01790; hypothetical protein [KO:K12275]
KNAG_0J01840  KNAG0J01840; hypothetical protein [KO:K09540]
KNAG_0F02620  KNAG0F02620; hypothetical protein [KO:K09490] [EC:3.6.4.10]
KNAG_0A05750  KNAG0A05750; hypothetical protein [KO:K03104]
KNAG_0D01080  KNAG0D01080; hypothetical protein [KO:K03108]
KNAG_0D00780  KNAG0D00780; hypothetical protein [KO:K03107]
KNAG_0G03340  KNAG0G03340; hypothetical protein [KO:K03105]
KNAG_0M01480  KNAG0M01480; hypothetical protein [KO:K13431]
KNAG_0F03280  KNAG0F03280; hypothetical protein [KO:K12272]
KNAG_0A05680  KNAG0A05680; hypothetical protein [KO:K01551] [EC:7.3.2.7 7.3.-.-]
KNAG_0M01060  KNAG0M01060; hypothetical protein [KO:K23387]
KNAG_0A01470  KNAG0A01470; hypothetical protein [KO:K23388]
KNAG_0M01170  KNAG0M01170; hypothetical protein [KO:K16365]
KNAG_0D03290  KNAG0D03290; hypothetical protein [KO:K22384]
KNAG_0B02980  KNAG0B02980; hypothetical protein [KO:K22386]
KNAG_0A04700  KNAG0A04700; hypothetical protein [KO:K27163]
KNAG_0L00260  KNAG0L00260; hypothetical protein [KO:K27164]
KNAG_0B01530  KNAG0B01530; hypothetical protein [KO:K27165]
KNAG_0M01390  KNAG0M01390; hypothetical protein [KO:K12946] [EC:3.4.-.-]
KNAG_0E03870  KNAG0E03870; hypothetical protein [KO:K12947] [EC:3.4.-.-]
KNAG_0E03060  KNAG0E03060; hypothetical protein [KO:K12948] [EC:3.4.-.-]
KNAG_0H00270  KNAG0H00270; hypothetical protein [KO:K13280] [EC:3.4.21.89]
KNAG_0E02010  KNAG0E02010; hypothetical protein [KO:K09647] [EC:3.4.21.-]
KNAG_0M02290  KNAG0M02290; hypothetical protein [KO:K09648] [EC:3.4.21.-]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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