KEGG   PATHWAY: lug03070
Entry
lug03070                    Pathway                                
Name
Bacterial secretion system - Luteimonas granuli
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
lug03070  Bacterial secretion system
lug03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Luteimonas granuli [GN:lug]
Gene
FPZ22_09160  TolC family outer membrane protein [KO:K12340]
FPZ22_03020  gspD; type II secretion system protein GspD [KO:K02453]
FPZ22_05120  hypothetical protein [KO:K02453]
FPZ22_09650  gspD; type II secretion system protein GspD [KO:K02453]
FPZ22_03015  hypothetical protein [KO:K02452]
FPZ22_03030  gspF; type II secretion system protein GspF [KO:K02455]
FPZ22_05070  type II secretion system F family protein [KO:K02455]
FPZ22_09605  type II secretion system F family protein [KO:K02455]
FPZ22_03035  gspG; type II secretion system protein GspG [KO:K02456]
FPZ22_05085  gspG; type II secretion system protein GspG [KO:K02456]
FPZ22_05090  type II secretion system protein [KO:K02456]
FPZ22_09610  gspG; type II secretion system protein GspG [KO:K02456]
FPZ22_03040  gspH; type II secretion system protein GspH [KO:K02457]
FPZ22_03045  gspI; type II secretion system protein GspI [KO:K02458]
FPZ22_09620  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02458]
FPZ22_03050  gspJ; type II secretion system protein GspJ [KO:K02459]
FPZ22_09625  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
FPZ22_03055  general secretion pathway protein GspK [KO:K02460]
FPZ22_09630  general secretion pathway protein GspK [KO:K02460]
FPZ22_03060  type II secretion system protein GspL [KO:K02461]
FPZ22_09635  PilN domain-containing protein [KO:K02461]
FPZ22_03065  type II secretion system protein M [KO:K02462]
FPZ22_09640  general secretion pathway protein GspM [KO:K02462]
FPZ22_03025  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
FPZ22_05075  type II secretion system protein [KO:K02454] [EC:7.4.2.8]
FPZ22_09600  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
FPZ22_11685  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
FPZ22_01865  secD; protein translocase subunit SecD [KO:K03072]
FPZ22_10665  secE; preprotein translocase subunit SecE [KO:K03073]
FPZ22_12785  secG; preprotein translocase subunit SecG [KO:K03075]
FPZ22_10830  secY; preprotein translocase subunit SecY [KO:K03076]
FPZ22_01870  yajC; preprotein translocase subunit YajC [KO:K03210]
FPZ22_07465  yidC; membrane protein insertase YidC [KO:K03217]
FPZ22_09845  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
FPZ22_01945  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
FPZ22_06815  secB; protein-export chaperone SecB [KO:K03071]
FPZ22_02840  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
FPZ22_07855  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
FPZ22_07850  tatB; twin-arginine translocase subunit TatB [KO:K03117]
FPZ22_07845  tatC; twin-arginine translocase subunit TatC [KO:K03118]
FPZ22_11095  hypothetical protein [KO:K03194]
FPZ22_11100  TrbC/VirB2 family protein [KO:K03197]
FPZ22_11105  hypothetical protein [KO:K03198]
FPZ22_11080  type IV secretion system protein VirB9 [KO:K03204]
FPZ22_11120  type IV secretion system protein [KO:K03201]
FPZ22_11075  type IV secretion system protein [KO:K03203]
FPZ22_11085  TrbI/VirB10 family protein [KO:K03195]
FPZ22_11110  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
FPZ22_11090  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
FPZ22_03845  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
FPZ22_01785  protein kinase [KO:K11912] [EC:2.7.11.1]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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