KEGG   PATHWAY: mbe04138
Entry
mbe04138                    Pathway                                
Name
Autophagy - yeast - Drepanopeziza brunnea
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
mbe04138  Autophagy - yeast
mbe04138

Other DBs
GO: 0006914
Organism
Drepanopeziza brunnea [GN:mbe]
Gene
MBM_08084  ras-2 protein [KO:K07827]
MBM_04305  hypothetical protein [KO:K07827]
MBM_00355  catalytic subunit of the PKA [KO:K04345] [EC:2.7.11.11]
MBM_07529  cAMP-dependent protein kinase A [KO:K04345] [EC:2.7.11.11]
MBM_04998  serine/threonine-protein kinase [KO:K21157] [EC:2.7.11.1]
MBM_04651  serine threonine protein kinase [KO:K12761] [EC:2.7.11.1]
MBM_07709  hypothetical protein [KO:K08269] [EC:2.7.11.1]
MBM_06377  autophagy protein Atg13 [KO:K08331]
MBM_00420  kinase activator [KO:K08329]
MBM_03027  putative Autophagy-related protein 9 [KO:K17907]
MBM_09979  ATG C terminal domain-containing protein [KO:K17906]
MBM_09583  protein-vacuolar targeting protein Atg18 [KO:K17908]
MBM_02769  autophagy protein Atg27 [KO:K21141]
MBM_05759  Autophagy-related protein 11 [KO:K08330]
MBM_06535  actin-like protein 2 [KO:K17260]
MBM_05207  actin-related protein 3 [KO:K18584]
MBM_06129  actin related protein 2/3 complex subunit [KO:K05757]
MBM_01424  ARP2/3 complex 34 kDa subunit [KO:K05758]
MBM_05464  ARP2/3 complex 21 kDa subunit [KO:K05756]
MBM_09627  ARP2/3 complex 20 kDa subunit [KO:K05755]
MBM_04130  ARP2/3 complex 16 kDa subunit [KO:K05754]
MBM_09495  cAMP-dependent protein kinase catalytic subunit [KO:K19800] [EC:2.7.11.1]
MBM_07936  TmkB [KO:K04464] [EC:2.7.11.24]
MBM_02845  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
MBM_07421  aminotransferase class I and II [KO:K00654] [EC:2.3.1.50]
MBM_09848  WD repeat domain-containing protein mip1 [KO:K07204]
MBM_05946  FAT domain-containing protein [KO:K07203] [EC:2.7.11.1]
MBM_04949  WD-repeat protein pop3 [KO:K08266]
MBM_04323  type 2A phosphatase-associated protein 42 [KO:K17606]
MBM_01984  serine/threonine-protein phosphatase pp2a catalytic subunit [KO:K04382] [EC:3.1.3.16]
MBM_00274  type 2A phosphatase activator TIP41 [KO:K17607]
MBM_00156  serine/threonine-protein kinase [KO:K12767] [EC:2.7.11.36]
MBM_08206  protein kinase [KO:K16196] [EC:2.7.11.1]
MBM_00615  eukaryotic translation initiation factor 2 alpha subunit [KO:K03237]
MBM_01539  negative regulator of the PHO system [KO:K06655] [EC:2.7.11.22]
MBM_07333  cyclin [KO:K21197]
MBM_02287  putative Autophagy-related protein 8 [KO:K08341]
MBM_03847  autophagy protein Apg6 [KO:K08334]
MBM_00840  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
MBM_07534  phosphatidylinositol 3 [KO:K00914] [EC:2.7.1.137]
MBM_03256  inositol polyphosphate kinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
MBM_06401  inositol polyphosphate kinase [KO:K07756] [EC:2.7.4.21]
MBM_02151  protein phosphatase [KO:K18083] [EC:3.1.3.64 3.1.3.95]
MBM_06435  ubiquitin-like autophagy protein Apg12 [KO:K08336]
MBM_06131  Autophagy-related protein 10 [KO:K17888]
MBM_05011  ATG5 protein [KO:K08339]
MBM_07537  autophagocytosis protein [KO:K08343]
MBM_06881  putative cysteine protease atg4 [KO:K08342] [EC:3.4.22.-]
MBM_09451  PX domain-containing protein [KO:K08502]
MBM_06519  vesicle transport V-SNARE protein [KO:K08493]
MBM_00560  synaptobrevin [KO:K08516]
MBM_07741  vesicular-fusion protein SEC18 [KO:K06027] [EC:3.6.4.6]
MBM_09010  vesicular-fusion protein sec17 [KO:K15296]
MBM_01081  ras-related protein-like protein [KO:K07897]
MBM_02461  Vacuolar fusion protein mon-1 [KO:K20195]
MBM_09605  vacuolar membrane protein [KO:K20179]
MBM_02814  vacuolar protein sorting [KO:K20180]
MBM_07087  Pep3/Vps18/deep orange family protein [KO:K20181]
MBM_02432  Sec1 family protein [KO:K20182]
MBM_00223  hypothetical protein [KO:K20177]
MBM_03452  vacuolar assembly/sorting protein VPS8 [KO:K20178]
MBM_08973  vacuolar sorting protein 39 domain 1 [KO:K20183]
MBM_04044  WD domain-containing protein [KO:K20184]
MBM_08220  vacuolar protein sorting-associated protein 45 [KO:K12479]
MBM_06769  aspartic endopeptidase Pep2 [KO:K01381] [EC:3.4.23.25]
MBM_07519  serine protease 2 [KO:K01336] [EC:3.4.21.48 3.4.21.-]
MBM_03464  cuticle-degrading serine protease [KO:K01336] [EC:3.4.21.48 3.4.21.-]
MBM_08196  autophagy related lipase [KO:K17900] [EC:3.1.1.3]
MBM_01620  putative Autophagy-related protein 22-2 [KO:K06902]
MBM_09892  putative Autophagy-related protein 22 [KO:K06902]
MBM_07250  putative amino acid transporter [KO:K14209]
MBM_07774  transmembrane amino acid transporter [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
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