KEGG   PATHWAY: paf03070
Entry
paf03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa M18
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
paf03070  Bacterial secretion system
paf03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa M18 [GN:paf]
Gene
PAM18_0793  putative outer membrane protein precursor [KO:K12340]
PAM18_5085  putative outer membrane protein precursor [KO:K12340]
PAM18_4685  putative outer membrane protein precursor [KO:K12340]
PAM18_3327  pscF; type III export protein PscF [KO:K03221]
PAM18_3350  pscO; translocation protein in type III secretion [KO:K04056]
PAM18_3351  pscP; translocation protein in type III secretion [KO:K04057]
PAM18_3345  hypothetical protein in type III secretion [KO:K04059]
PAM18_3330  pscC; Type III secretion outer membrane protein PscC precursor [KO:K03219]
PAM18_3348  popN; Type III secretion outer membrane protein PopN precursor [KO:K04058]
PAM18_3323  pscJ; type III export protein PscJ [KO:K03222]
PAM18_3353  pscR; type III secretion system protein [KO:K03226]
PAM18_3354  putative translocation protein in type III secretion [KO:K03227]
PAM18_3355  pscT; translocation protein in type III secretion [KO:K03228]
PAM18_3356  pscU; translocation protein in type III secretion [KO:K03229]
PAM18_3343  pcrD; type III secretory apparatus protein PcrD [KO:K03230]
PAM18_3349  type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
PAM18_3352  pscQ; type III secretion system protein [KO:K03225]
PAM18_3321  pscL; type III secretion system protein [KO:K03223]
PAM18_4353  putative type II secretion system protein [KO:K02453]
PAM18_3173  xqhA; secretion protein XqhA [KO:K02453]
PAM18_1858  xcpQ; general secretion pathway protein D [KO:K02453]
PAM18_4359  hypothetical protein [KO:K02452]
PAM18_3174  xphA; XphA [KO:K02452]
PAM18_1859  xcpP; secretion protein XcpP [KO:K02452]
PAM18_4351  putative type II secretion system protein [KO:K02455]
PAM18_1861  xcpS; general secretion pathway protein F [KO:K02455]
PAM18_2297  putative type II secretion system protein [KO:K02455]
PAM18_4357  HxcT pseudopilin [KO:K02456]
PAM18_2298  putative type II secretion system protein [KO:K02456]
PAM18_2299  putative type II secretion system protein [KO:K02456]
PAM18_1862  xcpT; general secretion pathway protein G [KO:K02456]
PAM18_4360  HxcU putative pseudopilin [KO:K02457]
PAM18_1863  xcpU; General secretion pathway outer membrane protein H precursor [KO:K02457]
PAM18_4358  HxcV putative pseudopilin [KO:K02458]
PAM18_2300  putative type II secretion system protein [KO:K02458]
PAM18_1864  xcpV; general secretion pathway protein I [KO:K02458]
PAM18_4361  HxcW putative pseudopilin [KO:K02459]
PAM18_2301  putative type II secretion system protein [KO:K02459]
PAM18_1865  xcpW; general secretion pathway protein J [KO:K02459]
PAM18_4356  HxcX atypical pseudopilin [KO:K02460]
PAM18_1866  xcpX; general secretion pathway protein K [KO:K02460]
PAM18_4355  type II secretion system protein [KO:K02461]
PAM18_1867  xcpY; general secretion pathway protein L [KO:K02461]
PAM18_4354  putative type II secretion system protein [KO:K02462]
PAM18_1868  xcpZ; general secretion pathway protein M [KO:K02462]
PAM18_4352  putative type II secretion system protein [KO:K02454] [EC:7.4.2.8]
PAM18_1860  xcpR; general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
PAM18_5328  putative secretion pathway ATPase [KO:K02454] [EC:7.4.2.8]
PAM18_1117  secD; preprotein translocase subunit SecD [KO:K03072]
PAM18_1118  secF; preprotein translocase subunit SecF [KO:K03074]
PAM18_0654  secE; preprotein translocase subunit SecE [KO:K03073]
PAM18_4855  secG; preprotein translocase subunit SecG [KO:K03075]
PAM18_0687  secY; preprotein translocase subunit SecY [KO:K03076]
PAM18_1116  yajC; preprotein translocase subunit YajC [KO:K03210]
PAM18_5696  putative inner membrane protein translocase component YidC [KO:K03217]
PAM18_4494  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
PAM18_0372  ftsY; signal recognition particle receptor FtsY [KO:K03110]
PAM18_5242  secB; preprotein translocase subunit SecB [KO:K03071]
PAM18_1199  ffh; signal recognition particle protein Ffh [KO:K03106] [EC:3.6.5.4]
PAM18_5183  tatA; twin arginine translocase protein A [KO:K03116]
PAM18_5184  tatB; sec-independent translocase [KO:K03117]
PAM18_5185  tatC; transport protein TatC [KO:K03118]
PAM18_5204  hypothetical protein [KO:K11904]
PAM18_3620  hypothetical protein [KO:K11904]
PAM18_0257  hypothetical protein [KO:K11904]
PAM18_1674  hypothetical protein [KO:K11904]
PAM18_5386  hypothetical protein [KO:K11904]
PAM18_0097  hypothetical protein [KO:K11904]
PAM18_0093  vgrG1; VgrG1 [KO:K11904]
PAM18_2287  hypothetical protein [KO:K11904]
PAM18_2668  hypothetical protein [KO:K11904]
PAM18_2674  hypothetical protein [KO:K11903]
PAM18_3619  hcpB; secreted protein Hcp [KO:K11903]
PAM18_0258  hcpB; secreted protein Hcp [KO:K11903]
PAM18_0087  hcp1; Hcp1 [KO:K11903]
PAM18_5387  hcpB; secreted protein Hcp [KO:K11903]
PAM18_3381  putative lipoprotein [KO:K11906]
PAM18_0082  hypothetical protein [KO:K11906]
PAM18_2680  hypothetical protein [KO:K11891]
PAM18_3378  hypothetical protein [KO:K11891]
PAM18_0079  icmF1; IcmF1 [KO:K11891]
PAM18_2679  hypothetical protein [KO:K11892]
PAM18_3379  putative outer membrane protein [KO:K11892]
PAM18_0080  hypothetical protein [KO:K11892]
PAM18_2670  putative ClpA/B-type protease [KO:K11907]
PAM18_3384  putative ClpA/B-type protease [KO:K11907]
PAM18_0092  clpV1; ClpV1 [KO:K11907]
PAM18_0083  fha1; Fha1 [KO:K11913]
PAM18_3377  stp1; serine/threonine phosphoprotein phosphatase Stp1 [KO:K11915] [EC:3.1.3.16]
PAM18_0077  pppA; PppA [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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