KEGG   PATHWAY: pdp04138
Entry
pdp04138                    Pathway                                
Name
Autophagy - yeast - Penicillium digitatum
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
pdp04138  Autophagy - yeast
pdp04138

Other DBs
GO: 0006914
Organism
Penicillium digitatum [GN:pdp]
Gene
PDIP_60730  RAS protein [KO:K07827]
PDIP_14290  Ras small monomeric GTPase RasB [KO:K07827]
PDIP_51730  Protein kinase A catalytic subunit 2 [KO:K04345] [EC:2.7.11.11]
PDIP_89420  CAMP-dependent protein kinase PKAC catalytic subunit [KO:K04345] [EC:2.7.11.11]
PDIP_68880  Serine/threonine protein kinase, putative [KO:K21157] [EC:2.7.11.1]
PDIP_07540  Carbon catabolite derepressing protein kinase Snf1, putative [KO:K12761] [EC:2.7.11.1]
PDIP_72530  Serine/threonine protein kinase (Pdd7p), putative [KO:K08269] [EC:2.7.11.1]
PDIP_80200  Autophagy protein Atg13, putative [KO:K08331]
PDIP_78420  Kinase activator (Atg17), putative [KO:K08329]
PDIP_43640  Autophagy protein Apg9, putative [KO:K17907]
PDIP_45000  Autophagy regulatory protein Atg2, putative [KO:K17906]
PDIP_60140  Protein-vacuolar targeting protein Atg18, putative [KO:K17908]
PDIP_05640  Atg27p [KO:K21141]
PDIP_30270  Atg11p [KO:K08330]
PDIP_27720  Actin-like protein, putative [KO:K17260]
PDIP_60290  Arp2/3 complex subunit (Arp3), putative [KO:K18584]
PDIP_68280  Actin-related protein 2/3 complex subunit 1A, putative [KO:K05757]
PDIP_10460  hypothetical protein [KO:K05758]
PDIP_47750  hypothetical protein [KO:K05756]
PDIP_62010  ARP2/3 complex 20 kDa subunit (P20-ARC), putative [KO:K05755]
PDIP_74910  Actin-related protein 2/3 complex subunit 5 [KO:K05754]
PDIP_69280  CAMP-dependent protein kinase-like, putative [KO:K19800] [EC:2.7.11.1]
PDIP_43770  hypothetical protein [KO:K04464] [EC:2.7.11.24]
PDIP_28620  Serine palmitoyltransferase 2, putative [KO:K00654] [EC:2.3.1.50]
PDIP_43590  hypothetical protein [KO:K00654] [EC:2.3.1.50]
PDIP_75690  TORC1 growth control complex subunit Kog1, putative [KO:K07204]
PDIP_64280  Tor [KO:K07203] [EC:2.7.11.1]
PDIP_40640  hypothetical protein [KO:K08266]
PDIP_60060  hypothetical protein [KO:K17606]
PDIP_39130  Serine/threonine-protein phosphatase [KO:K04382] [EC:3.1.3.16]
PDIP_14540  TOR signaling pathway protein TipA, putative [KO:K17607]
PDIP_04910  Serine threonine protein kinase, putative [KO:K12767] [EC:2.7.11.36]
PDIP_50530  Protein kinase (Gcn2), putative [KO:K16196] [EC:2.7.11.1]
PDIP_23830  Translation initiation factor 2 alpha subunit, putative [KO:K03237]
PDIP_81840  hypothetical protein [KO:K06655] [EC:2.7.11.22]
PDIP_54890  Cyclin-dependent protein kinase PhoA [KO:K06655] [EC:2.7.11.22]
PDIP_61460  G1/S-specific cyclin Pcl5, putative [KO:K21197]
PDIP_34700  Autophagy-related protein 8 [KO:K08341]
PDIP_03940  Atg6p [KO:K08334]
PDIP_39610  Vps15p [KO:K08333] [EC:2.7.11.1]
PDIP_51620  Vps34p [KO:K00914] [EC:2.7.1.137]
PDIP_60410  Arginine metabolism regulation protein iii [KO:K00915] [EC:2.7.1.140 2.7.1.151]
PDIP_59050  Inositol hexaphosphate kinase KCS1, putative [KO:K07756] [EC:2.7.4.21]
PDIP_73810  Protein phosphatase [KO:K18083] [EC:3.1.3.64 3.1.3.95]
PDIP_35590  Ubiquitin-like protein ATG12 [KO:K08336]
PDIP_56790  Autophagy ubiquitin-activating enzyme ApgG, putative [KO:K08337]
PDIP_68260  Atg10p [KO:K17888]
PDIP_71780  Autophagy protein 5 [KO:K08339]
PDIP_52150  Autophagy-related protein 3 [KO:K08343]
PDIP_01630  Autophagy cysteine endopeptidase Atg4, putative [KO:K08342] [EC:3.4.22.-]
PDIP_75580  SNARE complex subunit (Vam7), putative [KO:K08502]
PDIP_33040  Vti1p [KO:K08493]
PDIP_77490  SNARE protein Ykt6, putative [KO:K08516]
PDIP_29380  NsfA [KO:K06027] [EC:3.6.4.6]
PDIP_35370  hypothetical protein [KO:K15296]
PDIP_59530  Rab small monomeric GTPase Rab7, putative [KO:K07897]
PDIP_37480  Vacuolar fusion protein mon1 [KO:K20195]
PDIP_38520  Vacuolar protein sorting protein (VPS11), putative [KO:K20179]
PDIP_81730  Vacuolar protein sorting vps16, putative [KO:K20180]
PDIP_50000  Vacuolar protein sorting protein DigA [KO:K20181]
PDIP_78850  Vacuolar sorting protein, putative [KO:K20182]
PDIP_66830  TGF beta receptor associated protein 1, putative [KO:K20177]
PDIP_84110  Golgi complex component (Vps8), putative [KO:K20178]
PDIP_47570  Vacuolar morphogenesis protein AvaB, putative [KO:K20183]
PDIP_29830  Vacuolar assembly protein, putative [KO:K20184]
PDIP_18450  Vacuolar protein sorting-associated protein VpsB [KO:K12479]
PDIP_29610  Vacuolar protease A [KO:K01381] [EC:3.4.23.25]
PDIP_49700  Vacuolar serine protease [KO:K01336] [EC:3.4.21.48 3.4.21.-]
PDIP_63750  Autophagy related lipase Atg15, putative [KO:K17900] [EC:3.1.1.3]
PDIP_56870  hypothetical protein [KO:K06902]
PDIP_04560  hypothetical protein [KO:K06902]
PDIP_16140  Amino acid transporter, putative [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
LinkDB

DBGET integrated database retrieval system