KEGG   PATHWAY: pfs03070
Entry
pfs03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas fluorescens SBW25
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
pfs03070  Bacterial secretion system
pfs03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_0491  Putative outer membrane protein [KO:K12340]
PFLU_3849  Putative outer membrane lipoprotein [KO:K12340]
PFLU_0712  rspO; Uncharacterized protein [KO:K04056]
PFLU_0721  rscC; Type 3 secretion system secretin (T3SS secretin) [KO:K03219]
PFLU_4606  Secretory protein [KO:K03219]
PFLU_0726  rscJ; Lipoprotein [KO:K03222]
PFLU_0715  rscR; Putative hairpin type III secretion protein [KO:K03226]
PFLU_0716  rscS; Putative type III secretion membrane protein [KO:K03227]
PFLU_0717  rscT; Putative type III secretion protein [KO:K03228]
PFLU_0718  rscU; Putative type III secretion protein [KO:K03229]
PFLU_0714  rscQAB; Putative type III secretion protein [KO:K03225]
PFLU_0724  rspE; Putative type III secretion protein [KO:K03223]
PFLU_4070  General secretion pathway protein D [KO:K02453]
PFLU_2423  Putative type II secretion pathway protein D [KO:K02453]
PFLU_3232  General secretion pathway protein D/Q [KO:K02453]
PFLU_2417  Putative type II secretion system membrane protein C [KO:K02452]
PFLU_3238  Putative general secretory pathway protein C [KO:K02452]
PFLU_4079  Putative general secretion pathway protein F [KO:K02455]
PFLU_3230  General secretion pathway protein F/S [KO:K02455]
PFLU_2425  Putative type II secretion system protein F [KO:K02455]
PFLU_4078  Type II secretion system core protein G [KO:K02456]
PFLU_2419  Type II secretion system core protein G [KO:K02456]
PFLU_3236  Type II secretion system core protein G [KO:K02456]
PFLU_4077  Putative general secretion pathway protein H [KO:K02457]
PFLU_2416  General secretion pathway protein H (Type II secretion system protein H) [KO:K02457]
PFLU_3239  General secretion pathway protein H (Type II secretion system protein H) [KO:K02457]
PFLU_4076  Putative general secretion pathway protein I [KO:K02458]
PFLU_3237  General secretory pathway protein I/V [KO:K02458]
PFLU_2418  Putative type II secretion system, exported protein I [KO:K02458]
PFLU_4075  Putative general secretion pathway protein J [KO:K02459]
PFLU_2415  Type II secretion system protein J [KO:K02459]
PFLU_3240  Type II secretion system protein J [KO:K02459]
PFLU_4074  Putative general secretion pathway protein K [KO:K02460]
PFLU_3235  Type II secretion system protein K [KO:K02460]
PFLU_2420  Type II secretion system protein K [KO:K02460]
PFLU_4073  Putative general secretion pathway protein L [KO:K02461]
PFLU_2421  Putative type II secretion system protein L [KO:K02461]
PFLU_3234  Type II secretion system protein L (T2SS protein L) [KO:K02461]
PFLU_4072  Putative general secretion pathway protein M [KO:K02462]
PFLU_2422  Putative type II secretion pathway protein M [KO:K02462]
PFLU_3233  Putative general secretory pathway protein [KO:K02462]
PFLU_4080  Type II secretion system protein E (T2SS protein E) (Type II traffic warden ATPase) [KO:K02454] [EC:7.4.2.8]
PFLU_5867  Putative secretion-related ATP-binding protein [KO:K02454] [EC:7.4.2.8]
PFLU_2424  Type II secretion system protein E (T2SS protein E) (Type II traffic warden ATPase) [KO:K02454] [EC:7.4.2.8]
PFLU_3231  Type II secretion system protein E (T2SS protein E) (Type II traffic warden ATPase) [KO:K02454] [EC:7.4.2.8]
PFLU_5075  Protein translocase subunit SecD [KO:K03072]
PFLU_5074  Protein-export membrane protein SecF [KO:K03074]
PFLU_5540  secE; Protein translocase subunit SecE [KO:K03073]
PFLU_5256  Protein-export membrane protein SecG [KO:K03075]
PFLU_5507  secY; Protein translocase subunit SecY [KO:K03076]
PFLU_5076  Sec translocon accessory complex subunit YajC [KO:K03210]
PFLU_6134  Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) [KO:K03217]
PFLU_4933  Protein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
PFLU_5780  ftsY; Signal recognition particle receptor FtsY (SRP receptor) [KO:K03110]
PFLU_0340  secB; Protein-export protein SecB [KO:K03071]
PFLU_5013  Signal recognition particle protein (Fifty-four homolog) [KO:K03106] [EC:3.6.5.4]
PFLU_0384  Sec-independent protein translocase protein TatA [KO:K03116]
PFLU_0383  tatB; Sec-independent protein translocase protein [KO:K03117]
PFLU_0382  tatC; Sec-independent protein translocase protein TatC [KO:K03118]
PFLU_0453  Phage_base_V domain-containing protein [KO:K11904]
PFLU_2105  Phage_base_V domain-containing protein [KO:K11904]
PFLU_6026  Phage_base_V domain-containing protein [KO:K11904]
PFLU_6021  Uncharacterized protein [KO:K11903]
PFLU_3550  Uncharacterized protein [KO:K11903]
PFLU_4057  Uncharacterized protein [KO:K11903]
PFLU_6016  Putative lipoprotein [KO:K11906]
PFLU_3544  Putative membrane protein [KO:K11891]
PFLU_6013  Putative membrane protein [KO:K11891]
PFLU_3545  Putative outer membrane protein [KO:K11892]
PFLU_6014  Putative membrane protein [KO:K11892]
PFLU_6025  clpB2; Chaperone [KO:K11907]
PFLU_6010  Non-specific serine/threonine protein kinase (EC [KO:K11912] [EC:2.7.11.1]
PFLU_6017  FHA domain-containing protein [KO:K11913]
PFLU_3543  PPM-type phosphatase domain-containing protein [KO:K11915] [EC:3.1.3.16]
PFLU_6011  Putative phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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