KEGG   PATHWAY: pkm03070
Entry
pkm03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas kermanshahensis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
pkm03070  Bacterial secretion system
pkm03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas kermanshahensis [GN:pkm]
Gene
PZ739_25315  TolC family outer membrane protein [KO:K12340]
PZ739_11380  TolC family protein [KO:K12340]
PZ739_26095  gspD; type II secretion system secretin GspD [KO:K02453]
PZ739_05180  gspD; type II secretion system secretin GspD [KO:K02453]
PZ739_15210  secretin N-terminal domain-containing protein [KO:K02453]
PZ739_05175  pilus assembly protein PilZ [KO:K02452]
PZ739_26085  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
PZ739_05190  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
PZ739_14905  type II secretion system F family protein [KO:K02455]
PZ739_26080  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
PZ739_05195  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
PZ739_14900  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
PZ739_15200  type II secretion system protein [KO:K02456]
PZ739_15205  type II secretion system protein [KO:K02456]
PZ739_26075  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
PZ739_05200  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
PZ739_26070  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
PZ739_05205  type II secretion system protein GspI [KO:K02458]
PZ739_26065  gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459]
PZ739_05210  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
PZ739_26060  type II secretion system protein GspK [KO:K02460]
PZ739_05160  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
PZ739_05215  gspL; type II secretion system protein GspL [KO:K02461]
PZ739_26090  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
PZ739_26730  GspE/PulE family protein [KO:K02454] [EC:7.4.2.8]
PZ739_05185  ATPase, T2SS/T4P/T4SS family [KO:K02454] [EC:7.4.2.8]
PZ739_15235  GspE/PulE family protein [KO:K02454] [EC:7.4.2.8]
PZ739_04280  secD; protein translocase subunit SecD [KO:K03072]
PZ739_04285  secF; protein translocase subunit SecF [KO:K03074]
PZ739_02300  secE; preprotein translocase subunit SecE [KO:K03073]
PZ739_24270  secG; preprotein translocase subunit SecG [KO:K03075]
PZ739_02470  secY; preprotein translocase subunit SecY [KO:K03076]
PZ739_04275  yajC; preprotein translocase subunit YajC [KO:K03210]
PZ739_27835  yidC; membrane protein insertase YidC [KO:K03217]
PZ739_23160  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
PZ739_26305  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
PZ739_25960  secB; protein-export chaperone SecB [KO:K03071]
PZ739_05300  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
PZ739_25775  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
PZ739_05155  tatA; twin-arginine translocase TatA/TatE family subunit [KO:K03116]
PZ739_25780  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
PZ739_05150  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
PZ739_25785  tatC; twin-arginine translocase subunit TatC [KO:K03118]
PZ739_05145  tatC; twin-arginine translocase subunit TatC [KO:K03118]
PZ739_05235  ShlB/FhaC/HecB family hemolysin secretion/activation protein [KO:K11017]
PZ739_05230  hemagglutinin repeat-containing protein [KO:K11016]
PZ739_00355  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
PZ739_16690  tssI; type VI secretion system tip protein TssI/VgrG [KO:K11904]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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