KEGG   PATHWAY: ptep04814
Entry
ptep04814                   Pathway                                
Name
Motor proteins - Parasteatoda tepidariorum (common house spider)
Class
Cellular Processes; Cell motility
Pathway map
ptep04814  Motor proteins
ptep04814

Organism
Parasteatoda tepidariorum (common house spider) [GN:ptep]
Gene
107454755  cytoplasmic dynein 2 heavy chain 1-like [KO:K10414]
107454358  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
107447763  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
107456672  cytoplasmic dynein 1 light intermediate chain 2-like [KO:K10416]
107447830  cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
107448447  cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
107442126  dynein light chain roadblock-type 2 isoform X3 [KO:K10419]
107447396  dynein light chain roadblock-type 2 [KO:K10419]
122274029  dynein light chain roadblock-type 2-like [KO:K10419]
107447544  dynein light chain Tctex-type 1-like [KO:K10420]
107454707  dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
107449012  dynein axonemal heavy chain 2 isoform X4 [KO:K10408]
107449288  dynein axonemal intermediate chain 1-like [KO:K10409]
107442484  dynein axonemal intermediate chain 2-like [KO:K11143]
107447209  33 kDa inner dynein arm light chain, axonemal-like isoform X1 [KO:K10410]
107452909  axonemal dynein light intermediate polypeptide 1-like [KO:K10410]
107437671  dynein axonemal light chain 1-like [KO:K10411]
107447384  dynein axonemal light chain 4 isoform X1 [KO:K10412]
107457142  dynactin subunit 1 [KO:K04648]
107445530  dynactin subunit 2 [KO:K10424]
107438221  dynactin subunit 3 [KO:K10425]
122272793  dynactin subunit 3-like isoform X1 [KO:K10425]
107455426  dynactin subunit 4 [KO:K10426]
107452252  dynactin subunit 5 [KO:K10427]
107446209  dynactin subunit 6 isoform X1 [KO:K10428]
107453685  beta-centractin [KO:K16575]
107452326  actin-related protein 10 [KO:K16576]
107444388  F-actin-capping protein subunit alpha [KO:K10364]
107452621  F-actin-capping protein subunit alpha [KO:K10364]
107456688  F-actin-capping protein subunit beta [KO:K10365]
107453895  bicaudal D-related protein homolog isoform X1 [KO:K16756]
107454209  bicaudal D-related protein homolog [KO:K16756]
107437396  protein Hook homolog 3 isoform X1 [KO:K16536]
107438682  tubulin alpha chain, testis-specific [KO:K07374]
107450604  tubulin alpha chain [KO:K07374]
107453118  tubulin alpha chain [KO:K07374]
107456214  tubulin alpha-1 chain [KO:K07374]
107441194  tubulin alpha-1B chain [KO:K07374]
107447354  tubulin alpha-1 chain [KO:K07374]
107451299  tubulin alpha chain, testis-specific [KO:K07374]
107447737  tubulin alpha-1A chain isoform X1 [KO:K07374]
107442938  tubulin alpha-8 chain [KO:K07374]
107437364  tubulin beta chain [KO:K07375]
107452384  LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
107441778  tubulin beta chain-like [KO:K07375]
107441779  tubulin beta chain [KO:K07375]
107456680  tubulin beta chain [KO:K07375]
107449552  tubulin beta chain [KO:K07375]
107451828  tubulin beta chain [KO:K07375]
107436966  tubulin gamma-1 chain [KO:K10389]
107454022  tubulin delta chain isoform X1 [KO:K10390]
107440620  tubulin epsilon chain [KO:K10391]
107450311  kinesin heavy chain-like [KO:K10396] [EC:5.6.1.3]
107442085  kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
107444172  kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
107452458  kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
107443907  kinesin light chain [KO:K10407]
107453540  kinesin-like protein KIF3A [KO:K10394]
107445016  kinesin-like protein KIF3B isoform X1 [KO:K20196]
107452286  kinesin-associated protein 3 isoform X1 [KO:K25388]
107437949  osmotic avoidance abnormal protein 3 isoform X1 [KO:K20198]
107452683  kinesin-like protein unc-104 isoform X1 [KO:K10392]
107441478  kinesin-like protein KIF13A isoform X1 [KO:K17914]
107457012  kinesin-like protein KIF21A isoform X1 [KO:K24185]
107444097  kinesin-like protein KIF20B [KO:K10402]
107450648  kinesin-like protein KIF19 [KO:K26157]
107440991  kinesin-like protein KIF2A [KO:K10393]
107442034  kinesin-like protein KIF2A [KO:K10393]
107451800  carboxy-terminal kinesin 2 [KO:K10405] [EC:5.6.1.4]
107444553  unconventional myosin-Ic isoform X1 [KO:K10356]
107441660  unconventional myosin-Ie isoform X1 [KO:K10356]
107454372  unconventional myosin-Ia [KO:K10356]
107438270  unconventional myosin-Id [KO:K10356]
107446350  neither inactivation nor afterpotential protein C [KO:K08834] [EC:2.7.11.1]
107445441  unconventional myosin-Va isoform X1 [KO:K10357]
107445684  unconventional myosin-VI [KO:K10358]
107454979  myosin-VIIa isoform X1 [KO:K10359]
107449233  unconventional myosin-XVIIIa [KO:K10362]
107443488  myosin heavy chain, muscle isoform X4 [KO:K17751]
107457063  myosin heavy chain, muscle isoform X1 [KO:K17751]
107457041  myosin heavy chain, non-muscle isoform X1 [KO:K10352]
107441156  myosin heavy chain, non-muscle isoform X1 [KO:K10352]
107437045  myosin-2 essential light chain [KO:K12751]
107441001  myosin light chain 1 isoform X1 [KO:K12751]
107437570  myosin regulatory light chain sqh [KO:K12757]
107438410  myosin regulatory light chain 2 [KO:K12757]
107438412  myosin regulatory light polypeptide 9-like [KO:K12757]
107452695  myosin regulatory light chain sqh [KO:K12757]
107443858  myosin regulatory light chain 12A [KO:K12757]
107443493  actin, clone 403 [KO:K05692]
110281905  LOW QUALITY PROTEIN: actin, clone 403 [KO:K05692]
107448504  actin-2-like [KO:K05692]
107454166  actin, clone 403 [KO:K05692]
107454813  troponin I isoform X2 [KO:K10371]
107436183  troponin T isoform X1 [KO:K12046]
107454811  troponin T isoform X1 [KO:K12046]
107444246  tropomyosin isoform X2 [KO:K10373]
107452818  tropomyosin isoform X1 [KO:K10373]
Reference
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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