KEGG   ORTHOLOGY: K05692
Entry
K05692                      KO                                     
Symbol
ACTB_G1
Name
actin beta/gamma 1
Pathway
map04015  Rap1 signaling pathway
map04145  Phagosome
map04210  Apoptosis
map04390  Hippo signaling pathway
map04391  Hippo signaling pathway - fly
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map04611  Platelet activation
map04613  Neutrophil extracellular trap formation
map04670  Leukocyte transendothelial migration
map04714  Thermogenesis
map04745  Phototransduction - fly
map04810  Regulation of actin cytoskeleton
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04971  Gastric acid secretion
map05014  Amyotrophic lateral sclerosis
map05100  Bacterial invasion of epithelial cells
map05110  Vibrio cholerae infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05164  Influenza A
map05205  Proteoglycans in cancer
map05225  Hepatocellular carcinoma
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
map05416  Viral myocarditis
map05418  Fluid shear stress and atherosclerosis
Disease
H00101  Other phagocyte defects
H00604  Deafness, autosomal dominant
H01255  Juvenile-onset dystonia
H01705  Bilateral sudden sensorineural hearing loss
H02023  Baraitser-Winter syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05692  ACTB_G1; actin beta/gamma 1
   04390 Hippo signaling pathway
    K05692  ACTB_G1; actin beta/gamma 1
   04391 Hippo signaling pathway - fly
    K05692  ACTB_G1; actin beta/gamma 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K05692  ACTB_G1; actin beta/gamma 1
  09143 Cell growth and death
   04210 Apoptosis
    K05692  ACTB_G1; actin beta/gamma 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05692  ACTB_G1; actin beta/gamma 1
   04520 Adherens junction
    K05692  ACTB_G1; actin beta/gamma 1
   04530 Tight junction
    K05692  ACTB_G1; actin beta/gamma 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05692  ACTB_G1; actin beta/gamma 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05692  ACTB_G1; actin beta/gamma 1
   04613 Neutrophil extracellular trap formation
    K05692  ACTB_G1; actin beta/gamma 1
   04670 Leukocyte transendothelial migration
    K05692  ACTB_G1; actin beta/gamma 1
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K05692  ACTB_G1; actin beta/gamma 1
   04919 Thyroid hormone signaling pathway
    K05692  ACTB_G1; actin beta/gamma 1
  09154 Digestive system
   04971 Gastric acid secretion
    K05692  ACTB_G1; actin beta/gamma 1
  09157 Sensory system
   04745 Phototransduction - fly
    K05692  ACTB_G1; actin beta/gamma 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K05692  ACTB_G1; actin beta/gamma 1
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05692  ACTB_G1; actin beta/gamma 1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05692  ACTB_G1; actin beta/gamma 1
  09172 Infectious disease: viral
   05164 Influenza A
    K05692  ACTB_G1; actin beta/gamma 1
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05692  ACTB_G1; actin beta/gamma 1
   05130 Pathogenic Escherichia coli infection
    K05692  ACTB_G1; actin beta/gamma 1
   05132 Salmonella infection
    K05692  ACTB_G1; actin beta/gamma 1
   05131 Shigellosis
    K05692  ACTB_G1; actin beta/gamma 1
   05135 Yersinia infection
    K05692  ACTB_G1; actin beta/gamma 1
   05100 Bacterial invasion of epithelial cells
    K05692  ACTB_G1; actin beta/gamma 1
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K05692  ACTB_G1; actin beta/gamma 1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05692  ACTB_G1; actin beta/gamma 1
   05410 Hypertrophic cardiomyopathy
    K05692  ACTB_G1; actin beta/gamma 1
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K05692  ACTB_G1; actin beta/gamma 1
   05414 Dilated cardiomyopathy
    K05692  ACTB_G1; actin beta/gamma 1
   05416 Viral myocarditis
    K05692  ACTB_G1; actin beta/gamma 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K05692  ACTB_G1; actin beta/gamma 1
   03019 Messenger RNA biogenesis
    K05692  ACTB_G1; actin beta/gamma 1
   03036 Chromosome and associated proteins
    K05692  ACTB_G1; actin beta/gamma 1
   03029 Mitochondrial biogenesis
    K05692  ACTB_G1; actin beta/gamma 1
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05692  ACTB_G1; actin beta/gamma 1
   04147 Exosome
    K05692  ACTB_G1; actin beta/gamma 1
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Coactivators
    BAF/PBAF complex
     K05692  ACTB_G1; actin beta/gamma 1
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     K05692  ACTB_G1; actin beta/gamma 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    TIP60 complex
     K05692  ACTB_G1; actin beta/gamma 1
    NuA4 complex
     K05692  ACTB_G1; actin beta/gamma 1
  Chromatin remodeling factors
   BAF complex
    K05692  ACTB_G1; actin beta/gamma 1
   PBAF complex
    K05692  ACTB_G1; actin beta/gamma 1
   GBAF(ncBAF) complex
    K05692  ACTB_G1; actin beta/gamma 1
   SWR1 complex
    K05692  ACTB_G1; actin beta/gamma 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Actin cytoskeleton organization
    K05692  ACTB_G1; actin beta/gamma 1
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     K05692  ACTB_G1; actin beta/gamma 1
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K05692  ACTB_G1; actin beta/gamma 1
Genes
HSA: 60(ACTB) 71(ACTG1)
PTR: 450133(ACTB)
PPS: 100970542(ACTG1) 100987964 100990579 103784606
GGO: 101125802(ACTG1) 101127752
PON: 100173832(ACTB) 100441387(ACTG1)
NLE: 100598167(ACTG1) 100598411(ACTB)
MCC: 574285(ACTB) 705671 713687(ACTG1)
MCF: 101925802(ACTG1) 102120642 102139853(ACTB)
CSAB: 103243719(ACTG1) 103246953(ACTB)
CATY: 105574978 105577106 105588610(ACTG1) 105598339(ACTB)
RRO: 104654953(ACTG1) 104665228(ACTB)
RBB: 108534125(ACTG1) 108538237(ACTB)
CJC: 100406296(ACTB) 100409006
SBQ: 101037287(ACTB)
MMUR: 105868294(ACTB) 105884969(ACTG1)
OGA: 100953854(ACTG1) 100960800(ACTB) 100966429
MMU: 11461(Actb) 11465(Actg1)
MCAL: 110295381(Actb) 110304283(Actg1)
MPAH: 110313074(Actb)
RNO: 100361457 287876(Actg1) 81822(Actb)
MCOC: 116068700(Actb) 116078777(Actg1) 116099290
MUN: 110548804(Actg1) 110558188(Actb)
CGE: 100689477(Actb) 113830633(Actg1)
PLEU: 114680598(Actg1) 114684256 114705499(Actb)
NGI: 103730387(Actg1) 103748659(Actb)
HGL: 101702483(Actg1) 101717255(Actb)
CPOC: 100135470(Actb) 100731713(Actg1)
CCAN: 109700700
DORD: 105990935(Actb) 105998427(Actg1)
DSP: 122099409(Actg1) 122113601(Actb)
OCU: 100009272(ACTB)
OPI: 101518086(ACTG1) 101525072(ACTB)
TUP: 102498431(ACTG1)
CFA: 403580(ACTB)
AML: 100466132(ACTG1) 100481739
UMR: 103665813(ACTG1)
UAH: 113244519(ACTG1) 113267965(ACTB)
UAR: 123777926(ACTG1) 123802532(ACTB)
MPUF: 101679540(ACTG1) 101686268(ACTB)
ORO: 101375328(ACTB)
EJU: 114197483(ACTB) 114216053(ACTG1)
ZCA: 113932833(ACTB) 113939792(ACTG1)
MLX: 117999316(ACTB) 118024176(ACTG1)
FCA: 100144392(ACTG1) 101098507(ACTB)
PYU: 121017536(ACTB) 121018052(ACTG1)
PBG: 122471245(ACTB) 122485935(ACTG1)
PTG: 102971629(ACTG1)
PPAD: 109276785(ACTG1)
AJU: 106984514(ACTB) 106987399(ACTG1)
HHV: 120228024(ACTB) 120228303(ACTG1)
BTA: 280979(ACTB) 404122(ACTG1)
BOM: 102285564(ACTG1) 102286048(ACTB)
BIU: 109573916(ACTG1)
BBUB: 102393959(ACTG1)
CHX: 100860883(ACTG1) 102179831(ACTB)
OAS: 443052(ACTB) 443340(ACTG1)
ODA: 120856263(ACTB) 120866873(ACTG1) 120873725
CCAD: 122432952(ACTB) 122438358(ACTG1)
SSC: 397653(ACTG1) 414396(ACTB)
CFR: 102514032(ACTB) 116660822
CDK: 105104247(ACTB) 105105716
BACU: 103005004(ACTG1) 103015338(ACTB)
LVE: 103077223(ACTB) 103086383(ACTG1)
OOR: 101271282(ACTG1) 101277826(ACTB)
DLE: 111170344(ACTB) 111182710(ACTG1)
PCAD: 102988048(ACTG1) 102988905
PSIU: 116739532(ACTB) 116745324(ACTG1)
ECB: 100033878(ACTB) 100050139(ACTG1)
EPZ: 103551082(ACTG1)
EAI: 106845778(ACTG1)
MYB: 102251030 102263592(ACTG1)
MYD: 102772396(ACTB)
MMYO: 118659361(ACTB) 118671408(ACTG1) 118674776
MNA: 107537600(ACTB) 107539076(ACTG1)
PKL: 118704529(ACTG1) 118710780(ACTB)
HAI: 109380220(ACTB) 109393048(ACTG1)
DRO: 112298712(ACTG1) 112319437(ACTB)
SHON: 118995015(ACTB) 119002891(ACTG1)
AJM: 119041512(ACTB) 119046540 119058560(ACTG1)
PDIC: 114504029(ACTG1) 114509151(ACTB)
PHAS: 123807437(ACTB) 123816905(ACTG1)
MMF: 118616016(ACTB) 118635031(ACTG1)
RFQ: 117013189(ACTG1) 117016810(ACTB)
PALE: 102884158(ACTG1) 102884469(ACTB)
PGIG: 120599974(ACTG1) 120608145 120615525(ACTB)
PVP: 105294565(ACTB) 105301152(ACTG1)
RAY: 107515934(ACTB) 107520262(ACTG1)
MJV: 108399416(ACTB)
TOD: 119230923(ACTG1) 119241647(ACTB)
LAV: 100654618(ACTB) 100670743(ACTG1)
TMU: 101344372
SHR: 100919051(ACTB) 100928302(ACTG1)
PCW: 110218220(ACTG1) 110223114(ACTB)
OAA: 100078865(ACTB) 100085078(ACTG1)
GGA: 396526(ACTB) 415296(ACTG1) 776816
PCOC: 116232509(ACTG1) 116237546(ACTB) 116244547
MGP: 100303677(ACTB) 100542800
CJO: 107320606(ACTB) 107322234(ACTG1)
NMEL: 110403650 110406159(ACTB) 110407139(ACTG1)
APLA: 101800437(ACTB)
ACYG: 106032077(ACTB)
TGU: 115496608 115497627(ACTG1) 751978(ACTB)
LSR: 110472460(ACTG1) 110481083(ACTB)
SCAN: 103817621(ACTB)
PMOA: 120504844 120505418(ACTG1) 120513236(ACTB)
OTC: 121334393(ACTB) 121338266(ACTG1) 121343627
PRUF: 121350746(ACTB) 121363408(ACTG1) 121365545
GFR: 102041442(ACTB)
FAB: 101813373(ACTB)
PHI: 102106742(ACTB)
PMAJ: 107211173(ACTB) 107212453(ACTG1)
CCAE: 111936114(ACTB)
CCW: 104684799(ACTB) 120410965(ACTG1)
ETL: 114060184(ACTB) 114068207(ACTG1)
ZAB: 102067189(ACTB)
FPG: 101912716(ACTB) 101924846
FCH: 102050787(ACTB) 102056825
CLV: 102086906(ACTB)
EGZ: 104130834 104132602(ACTB)
NNI: 104016716
ACUN: 113483859 113485595(ACTB)
TALA: 104356423 104367006(ACTB) 104367721(ACTG1)
PADL: 103913542(ACTB)
ACHC: 115336033(ACTB) 115340949(ACTG1) 115341775
AROW: 112966901(ACTG1) 112967343 112974241(ACTB)
NPD: 112945270(ACTG1) 112950999 112959944(ACTB)
ASN: 102386754(ACTB)
AMJ: 102565683(ACTB)
CPOO: 109307935(ACTBL2) 109308866 109309184 109314696(ACTB) 109314911(ACTG1)
CMY: 102930389(ACTG1) 102932311 102934751(ACTBL2) 102937126(ACTB) 102941355(ACTL8)
CPIC: 101940236(ACTG1) 101941176(ACTB) 101948091 101953083(ACTBL2)
TST: 117867995(ACTL8) 117879462(ACTBL2) 117883668 117883704(ACTB) 117884503 117887319(ACTG1)
MRV: 120371790(ACTRT3) 120372849(ACTB) 120373001 120374144 120374473 120383175(ACTG1) 120387832(ACTL8) 120407736(ACTBL2)
ACS: 100337533(actb) 100564373(actg1) 100567488
PVT: 110083726(ACTB)
PBI: 103050159(ACTL8) 103063147(ACTG1)
PMUR: 107286753(ACTG1) 107298106
TSR: 106548496
PGUT: 117662974(ACTG1) 117676791(ACTB)
VKO: 123024932(ACTB) 123025631(ACTRT3) 123033814 123036901(ACTG1)
PMUA: 114584064(ACTB) 114588783(ACTG1)
GJA: 107108307(ACTG1) 107117852
XLA: 100337595(actg1.S) 108703086(actb.S) 398459(actb.L) 734918(actg1.L)
XTR: 394957(actg1) 407952(actb)
NPR: 108796718(ACTG1) 108799803
RTEM: 120919014(ACTG1) 120943679(ACTB)
BBUF: 121003202(ACTG1) 121008493
BGAR: 122939974(ACTG1) 122944482(ACTB)
DRE: 57934(actb1) 57935(actb2)
SRX: 107722944
CCAR: 109051881
IPU: 100526698(actb2) 108258691(actb1)
PHYP: 113535507 113535975(actb)
SMEO: 124375693(actb2) 124377796(actb1)
TFD: 113640465(actb1) 113643994(actb2)
AMEX: 103030443(actb) 103039558
EEE: 113580904 113585569(actb)
TRU: 101073736(actb) 101079312(actbb)
LCO: 104921174 104932075(actb)
NCC: 104951171(actb)
CGOB: 115012743(actb) 115019468
ELY: 117255634(actb1) 117268637(actb2)
PLEP: 121941735(actb1) 121944078 121944669 121957309(actb2)
SLUC: 116042675(actb1) 116065273(actb2)
ECRA: 117952974(actb1) 117957767(actb2)
GAT: 100174883(actb2) 120824906(actb1)
PPUG: 119217665(actb1) 119219914(actb2)
CUD: 121507739(actb1) 121529367(actb2)
MZE: 101470738(actb)
ONL: 100534414(actb)
OLA: 100049433(actb) 101168921
OML: 112137204(actb1) 112146789(actb2)
XMA: 102218394 102222885(actb)
XCO: 114144351 114159761(actb)
XHE: 116719700 116735266(actb)
PRET: 103462148
PFOR: 103136367 103153440(actb)
PLAI: 106948335 106956540(actb)
PMEI: 106908123 106927995(actb)
GAF: 122822212(actb2) 122828983(actb1)
CVG: 107087176(actb)
CTUL: 119771367(actb2) 119782358 119783702(actb1)
NFU: 107389815
KMR: 108236185(actb2)
ALIM: 106519625
NWH: 119421521(actb2) 119422439
AOCE: 111585137
CSEM: 103383494 103393304(actb)
SSEN: 122759849(actb2) 122770925(actb1)
HHIP: 117766264(actb2) 117770449(actb1)
LCF: 108877582(actb)
SDU: 111216734 111230355(actb)
SLAL: 111647584 111673001(actb)
XGL: 120799714(actb1) 120807260(actb2)
HCQ: 109520242
BPEC: 110153521 110162397(actb)
MALB: 109972432(actb) 109973284
SASA: 100136352(actb) 106564005
OTW: 112240902
SFM: 108922540 108926888(actb)
PKI: 111845463
LOC: 102690749(actg1) 102696204(actb)
LCM: 102362654(ACTB)
CMK: 103186865(actb)
RTP: 109920530(actb)
SKO: 100303600(act1)
DME: Dmel_CG4027(Act5C)
DER: 6551195
DSE: 6612339
DSI: Dsimw501_GD16764(Dsim_GD16764)
DYA: Dyak_GE17558(Dyak_Act57B)
DAN: 6504746
DSR: 110189526
DPE: 6599243
DWI: 6641346
DAZ: 108619712
DNV: 115565553
DHE: 111597353
DVI: 6636049
CCAT: 101458512
BOD: 106623778
MDE: 101888968
LCQ: 111678903
AGA: AgaP_AGAP000651(ACT5C_ANOGA)
ACOZ: 120951068
AARA: 120906795
AAG: 5574526
AALB: 109397804
CPII: 120421049
CNS: 116343954
AME: 406122(Arp1)
ACER: 107999330
ALAB: 122716691
BIM: 100748723
BBIF: 117210151
BVK: 117242144
BVAN: 117159407
BTER: 100646910
BPYO: 122568952
CCAL: 108632332
OBB: 114871202
MGEN: 117224629
NMEA: 116428897
CGIG: 122402745
SOC: 105205810
MPHA: 105828314
AEC: 105144390
ACEP: 105625474
PBAR: 105428683
VEM: 105565205
HST: 105183366
DQU: 106749622
CFO: 105251923
FEX: 115239222
LHU: 105667510
PGC: 109859067
OBO: 105278430
PCF: 106790823
PFUC: 122518098
VPS: 122627602
NVI: 100116604(Arp1)
CSOL: 105359224
TPRE: 106650455
MDL: 103573976
CGLO: 123266287
FAS: 105265531
DAM: 107048773
AGIF: 122850281
CCIN: 107268983
TCA: 659219(Arp1)
DPA: 109536631
ATD: 109608430
NVL: 108557032
APLN: 108735253
BMOR: 100145916(A4)
BMAN: 114253301
PPOT: 106107059
ZCE: 119832439
HAW: 110378449
TNL: 113506179
API: 100145822
DNX: 107168325
AGS: 114132557
RMD: 113548295
BTAB: 109032176
CLEC: 106669801
ZNE: 110827707
FCD: 110848783
DPX: DAPPUDRAFT_228751(ACT1B)
PVM: 113813020
HAZT: 108669732
TUT: 107362975
CSCU: 111618030
SDM: 118193407
CEL: CELE_M03F4.2(act-4) CELE_T04C12.4(act-3) CELE_T04C12.5(act-2) CELE_T04C12.6(act-1) CELE_T25C8.2(act-5)
BMY: BM_BM5086(Bm5086) BM_BM5544(Bma-act-5) BM_BM8524(Bm8524) BM_BM9237(Bm9237) BM_BM9238(Bm9238)
TSP: Tsp_08166
PCAN: 112575079
MYI: 110459362
OBI: 106870394
 » show all
Reference
PMID:2795655
  Authors
Krause M, Wild M, Rosenzweig B, Hirsh D
  Title
Wild-type and mutant actin genes in Caenorhabditis elegans.
  Journal
J Mol Biol 208:381-92 (1989)
DOI:10.1016/0022-2836(89)90503-2
  Sequence
Reference
PMID:1734024
  Authors
Ohmori H, Toyama S, Toyama S
  Title
Direct proof that the primary site of action of cytochalasin on cell motility processes is actin.
  Journal
J Cell Biol 116:933-41 (1992)
DOI:10.1083/jcb.116.4.933
  Sequence
[hsa:60]
Reference
PMID:3737401
  Authors
Erba HP, Gunning P, Kedes L
  Title
Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes.
  Journal
Nucleic Acids Res 14:5275-94 (1986)
DOI:10.1093/nar/14.13.5275
  Sequence
[hsa:71]
LinkDB

DBGET integrated database retrieval system