KEGG   PATHWAY: pum03070
Entry
pum03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas umsongensis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
pum03070  Bacterial secretion system
pum03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas umsongensis [GN:pum]
Gene
HGP31_02710  TolC family outer membrane protein [KO:K12340]
HGP31_09065  TolC family outer membrane protein [KO:K12340]
HGP31_22670  sctF; type III secretion system needle filament subunit SctF [KO:K03221]
HGP31_22760  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
HGP31_22735  flagellar motor switch/type III secretory pathway protein [KO:K03225]
HGP31_02340  gspD; type II secretion system secretin GspD [KO:K02453]
HGP31_12405  secretion type II protein [KO:K02453]
HGP31_02335  hypothetical protein [KO:K02452]
HGP31_02350  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
HGP31_12330  type II secretion system F family protein [KO:K02455]
HGP31_02355  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
HGP31_12335  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
HGP31_12410  type II secretion system protein [KO:K02456]
HGP31_12415  type II secretion system protein [KO:K02456]
HGP31_02360  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
HGP31_02365  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
HGP31_02370  gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459]
HGP31_02375  general secretion pathway protein GspK [KO:K02460]
HGP31_02380  type II secretory protein pull [KO:K02461]
HGP31_02385  type II secretion system protein M [KO:K02462]
HGP31_02345  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
HGP31_12380  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
HGP31_29895  tadA; Flp pilus assembly complex ATPase component TadA [KO:K02454] [EC:7.4.2.8]
HGP31_05290  secD; protein translocase subunit SecD [KO:K03072]
HGP31_05295  secF; protein translocase subunit SecF [KO:K03074]
HGP31_28270  secE; preprotein translocase subunit SecE [KO:K03073]
HGP31_04090  secG; preprotein translocase subunit SecG [KO:K03075]
HGP31_28105  secY; preprotein translocase subunit SecY [KO:K03076]
HGP31_05285  yajC; preprotein translocase subunit YajC [KO:K03210]
HGP31_00595  yidC; membrane protein insertase YidC [KO:K03217]
HGP31_25030  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
HGP31_29455  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
HGP31_01955  secB; protein-export chaperone SecB [KO:K03071]
HGP31_05550  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
HGP31_02165  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
HGP31_02160  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
HGP31_02155  tatC; twin-arginine translocase subunit TatC [KO:K03118]
HGP31_03405  type VI secretion protein [KO:K11904]
HGP31_17280  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
HGP31_17640  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
HGP31_20420  tssI; type VI secretion system tip protein VgrG [KO:K11904]
HGP31_17650  Hcp family type VI secretion system effector [KO:K11903]
HGP31_17595  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
HGP31_07305  type VI secretion protein VasK [KO:K11891]
HGP31_17235  type VI secretion protein VasK [KO:K11891]
HGP31_17615  type VI secretion protein VasK [KO:K11891]
HGP31_17660  DotU family type IV/VI secretion system protein [KO:K11892]
HGP31_17645  tssH; type VI secretion system ATPase TssH [KO:K11907]
HGP31_30320  VWA domain-containing protein [KO:K11912] [EC:2.7.11.1]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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