KEGG   PATHWAY: salz03070
Entry
salz03070                   Pathway                                
Name
Bacterial secretion system - Salmonella sp. SSDFZ69
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
salz03070  Bacterial secretion system
salz03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Salmonella sp. SSDFZ69 [GN:salz]
Gene
EOS98_03380  tolC; outer membrane channel protein TolC [KO:K12340]
EOS98_12440  type III secretion system needle protein SsaG [KO:K03221]
EOS98_05135  type III secretion system needle complex protein PrgI [KO:K03221]
EOS98_12500  SPI-2 type III secretion system protein SpiA [KO:K03219]
EOS98_12425  SPI-2 type III secretion system apparatus lipoprotein SsaJ [KO:K03222]
EOS98_12375  SPI-2 type III secretion system export apparatus protein SsaR [KO:K03226]
EOS98_12370  SPI-2 type III secretion system apparatus protein SsaS [KO:K03227]
EOS98_12365  SPI-2 type III secretion system apparatus protein SsaT [KO:K03228]
EOS98_12360  SPI-2 type III secretion system apparatus protein SsaU [KO:K03229]
EOS98_12400  SPI-2 type III secretion system apparatus protein SsaV [KO:K03230]
EOS98_05020  type III secretion system export apparatus protein InvA [KO:K03230]
EOS98_12395  EscN/YscN/HrcN family type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
EOS98_12380  SPI-2 type III secretion system apparatus protein SsaQ [KO:K03225]
EOS98_05045  SPI-1 type III secretion system protein SpaO [KO:K03225]
EOS98_17070  secD; protein translocase subunit SecD [KO:K03072]
EOS98_17065  secF; protein translocase subunit SecF [KO:K03074]
EOS98_21595  secE; preprotein translocase subunit SecE [KO:K03073]
EOS98_02820  secG; preprotein translocase subunit SecG [KO:K03075]
EOS98_02175  secY; preprotein translocase subunit SecY [KO:K03076]
EOS98_17075  yajC; preprotein translocase subunit YajC [KO:K03210]
EOS98_23125  yidC; membrane protein insertase YidC [KO:K03217]
EOS98_18550  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
EOS98_18555  secM; secA regulator SecM [KO:K13301]
EOS98_01450  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
EOS98_00730  secB; protein-export chaperone SecB [KO:K03071]
EOS98_05805  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
EOS98_22460  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
EOS98_22455  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
EOS98_22450  tatC; Sec-independent protein translocase subunit TatC [KO:K03118]
EOS98_15960  tatE; twin-arginine translocase subunit TatE [KO:K03425]
EOS98_24405  transglycosylase [KO:K03194]
EOS98_24410  TriB protein [KO:K03197]
EOS98_24420  type IV secretion system protein VirB5 [KO:K03200]
EOS98_24450  virB9; P-type conjugative transfer protein VirB9 [KO:K03204]
EOS98_24425  TriE protein [KO:K03201]
EOS98_24445  type IV secretion system protein [KO:K03203]
EOS98_24455  TrbI/VirB10 family protein [KO:K03195]
EOS98_24415  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
EOS98_24460  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
EOS98_24465  conjugal transfer protein TraG [KO:K03205] [EC:7.4.2.8]
EOS98_17750  tssI; type VI secretion system tip protein VgrG [KO:K11904]
EOS98_17800  Hcp1 family type VI secretion system effector [KO:K11903]
EOS98_17815  Hcp1 family type VI secretion system effector [KO:K11903]
EOS98_03665  Hcp1 family type VI secretion system effector [KO:K11903]
EOS98_17795  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
EOS98_17770  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
EOS98_17785  tssL; type VI secretion system protein TssL [KO:K11892]
EOS98_17840  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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