KEGG   PATHWAY: slr02010
Entry
slr02010                    Pathway                                
Name
ABC transporters - Salinispira pacifica
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
slr02010  ABC transporters
slr02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Salinispira pacifica [GN:slr]
Gene
L21SP2_0373  Ferric iron ABC transporter, iron-binding protein [KO:K02012]
L21SP2_0743  Ferric iron ABC transporter, iron-binding protein [KO:K02012]
L21SP2_0374  hypothetical protein [KO:K02011]
L21SP2_0744  Ferric iron ABC transporter, permease protein [KO:K02011]
L21SP2_0375  Putrescine transport ATP-binding protein PotA [KO:K02010] [EC:7.2.2.7]
L21SP2_0745  Ferric iron ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
L21SP2_1001  Glycine betaine ABC transport system, glycine betaine-binding protein OpuAC [KO:K02002]
L21SP2_3427  Glycine betaine ABC transport system, glycine betaine-binding protein OpuAC [KO:K02002]
L21SP2_3428  Glycine betaine ABC transport system, permease protein OpuAB [KO:K02001]
L21SP2_3429  Glycine betaine ABC transport system, ATP-binding protein OpuAA [KO:K02000] [EC:7.6.2.9]
L21SP2_2147  Osmoprotectant ABC transporter binding protein YehZ [KO:K05845]
L21SP2_2144  Osmoprotectant ABC transporter inner membrane protein YehW [KO:K05846]
L21SP2_2146  Glycine betaine/carnitine/choline ABC transporter, permease protein [KO:K05846]
L21SP2_2145  L-proline glycine betaine ABC transport system permease protein ProV [KO:K05847] [EC:7.6.2.9]
L21SP2_0211  Multiple sugar ABC transporter, ATP-binding protein [KO:K10112] [EC:7.5.2.-]
L21SP2_2491  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE [KO:K15770]
L21SP2_2191  Maltose/maltodextrin ABC transporter, permease protein MalF [KO:K15771]
L21SP2_2490  Maltose/maltodextrin ABC transporter, permease protein MalF [KO:K15771]
L21SP2_2192  Maltose/maltodextrin ABC transporter, permease protein MalG [KO:K15772]
L21SP2_2489  Maltose/maltodextrin ABC transporter, permease protein MalG [KO:K15772]
L21SP2_3088  extracellular solute-binding protein, family 1 [KO:K10117]
L21SP2_3087  N-Acetyl-D-glucosamine ABC transport system, permease protein [KO:K10118]
L21SP2_3086  sugar ABC transporter (permease) [KO:K10119]
L21SP2_2956  Alpha-glucosides-binding periplasmic protein AglE precursor [KO:K10232]
L21SP2_2955  ABC alpha-glucoside transporter, inner membrane subunit AglF [KO:K10233]
L21SP2_2954  Alpha-glucoside transport system permease protein AglG [KO:K10234]
L21SP2_0764  Polysaccharide ABC transporter substrate-binding protein [KO:K17318]
L21SP2_0761  putative beta-xyloside ABC transporter, permease component [KO:K17319]
L21SP2_0763  Xylose ABC transporter, permease component [KO:K17320]
L21SP2_0756  ABC-type sugar transport system, periplasmic component [KO:K10240]
L21SP2_2522  hypothetical protein [KO:K10240]
L21SP2_0757  sugar ABC transporter, permease protein [KO:K10241]
L21SP2_2521  putative alpha-xyloside ABC transporter, permease component [KO:K10241]
L21SP2_2520  putative chitobiose ABC transport system, permease protein 2 [KO:K10242]
L21SP2_0758  putative alpha-xyloside ABC transporter, permease component [KO:K10242]
L21SP2_0527  hypothetical protein [KO:K17244]
L21SP2_0528  sugar ABC transporter, permease protein [KO:K17245]
L21SP2_0529  ABC-type sugar transport system, permease component [KO:K17246]
L21SP2_1945  Unspecified monosaccharide ABC transport system, substrate-binding component [KO:K07335]
L21SP2_1943  Unspecified monosaccharide ABC transport system, permease component Ia [KO:K23535]
L21SP2_1942  Unspecified monosaccharide ABC transport system, permease component 2 [KO:K23536]
L21SP2_1944  Unspecified monosaccharide ABC transport system, ATP-binding protein [KO:K23537]
L21SP2_1510  Ribose ABC transport system, periplasmic ribose-binding protein RbsB [KO:K10439]
L21SP2_1508  Ribose ABC transport system, permease protein RbsC [KO:K10440]
L21SP2_1511  Ribose ABC transport system, permease protein RbsC [KO:K10440]
L21SP2_1509  Putative ribose/galactose/methyl galactoside import ATP-binding protein 1 [KO:K10441] [EC:7.5.2.7]
L21SP2_1512  Ribose ABC transport system, high affinity permease RbsD [KO:K06726] [EC:5.4.99.62]
L21SP2_2386  Xylose ABC transporter, periplasmic xylose-binding protein XylF [KO:K10543]
L21SP2_2387  Xylose ABC transporter, periplasmic xylose-binding protein XylF [KO:K10543]
L21SP2_2383  L-arabinose transport system permease protein [KO:K10544]
L21SP2_2384  D-xylose transport ATP-binding protein XylG [KO:K10545] [EC:7.5.2.10]
L21SP2_0463  Phosphate ABC transporter, periplasmic phosphate-binding protein PstS [KO:K02040]
L21SP2_0464  Phosphate transport system permease protein PstC [KO:K02037]
L21SP2_0465  Phosphate transport system permease protein PstA [KO:K02038]
L21SP2_0466  Phosphate transport ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
L21SP2_1482  Phosphonate ABC transporter phosphate-binding periplasmic component [KO:K02044]
L21SP2_1528  Phosphonate ABC transporter phosphate-binding periplasmic component [KO:K02044]
L21SP2_1484  Phosphonate ABC transporter permease protein phnE [KO:K02042]
L21SP2_1530  Phosphonate ABC transporter permease protein phnE2 [KO:K02042]
L21SP2_1531  Phosphonate ABC transporter permease protein phnE1 [KO:K02042]
L21SP2_1483  Phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
L21SP2_1529  Phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
L21SP2_2627  Amino acid ABC transporter, amino acid-binding/permease protein [KO:K23059]
L21SP2_2626  Amino acid ABC transporter, amino acid-binding/permease protein [KO:K17077]
L21SP2_2625  Glutamate transport ATP-binding protein [KO:K23060] [EC:7.4.2.1]
L21SP2_1968  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
L21SP2_2405  hypothetical protein [KO:K01999]
L21SP2_3074  Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
L21SP2_0633  Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
L21SP2_0629  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
L21SP2_1969  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
L21SP2_3073  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
L21SP2_0630  Branched-chain amino acid transport system permease protein LivM [KO:K01998]
L21SP2_1970  Branched-chain amino acid transport system permease protein LivM [KO:K01998]
L21SP2_3072  Branched-chain amino acid transport system permease protein LivM [KO:K01998]
L21SP2_0631  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
L21SP2_1971  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
L21SP2_3071  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
L21SP2_0632  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
L21SP2_1972  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
L21SP2_3070  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
L21SP2_0701  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K15580]
L21SP2_0702  Oligopeptide transport system permease protein OppB [KO:K15581]
L21SP2_0705  Oligopeptide transport ATP-binding protein OppD [KO:K15583]
L21SP2_0706  Oligopeptide transport ATP-binding protein OppF [KO:K10823]
L21SP2_2735  ABC-type Fe3+-siderophore transport system, periplasmic iron-binding component [KO:K25286]
L21SP2_0599  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
L21SP2_2734  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
L21SP2_0598  ABC-type Fe3+-siderophore transport system, permease 2 component [KO:K23187]
L21SP2_2733  hypothetical protein [KO:K23187]
L21SP2_0597  ABC-type Fe3+-siderophore transport system, ATPase component [KO:K23188] [EC:7.2.2.17 7.2.2.-]
L21SP2_2732  hypothetical protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
L21SP2_0378  Zinc ABC transporter, periplasmic-binding protein ZnuA [KO:K09815]
L21SP2_0376  Zinc ABC transporter, inner membrane permease protein ZnuB [KO:K09816]
L21SP2_0377  Zinc ABC transporter, ATP-binding protein ZnuC [KO:K09817] [EC:7.2.2.20]
L21SP2_0535  Manganese ABC transporter, periplasmic-binding protein SitA [KO:K11707]
L21SP2_0533  Manganese ABC transporter, inner membrane permease protein SitC [KO:K11708]
L21SP2_0532  Manganese ABC transporter, inner membrane permease protein SitD [KO:K11709]
L21SP2_0534  Manganese ABC transporter, ATP-binding protein SitB [KO:K11710] [EC:7.2.2.5]
L21SP2_1670  Substrate-specific component BioY of biotin ECF transporter [KO:K03523]
L21SP2_1668  hypothetical protein [KO:K16783]
L21SP2_1669  ATPase component of general energizing module of ECF transporter [KO:K16784] [EC:7.6.2.-]
L21SP2_0610  Transmembrane component of energizing module of ECF transporter [KO:K16785]
L21SP2_1716  exported protein (tpn38b) [KO:K23510]
L21SP2_1712  Unspecified monosaccharide ABC transport system, permease component 2 [KO:K23512]
L21SP2_1715  hypothetical protein [KO:K23513]
L21SP2_2582  ABC-type multidrug transporter, permease component [KO:K09694]
L21SP2_2583  ABC transporter protein [KO:K09695]
L21SP2_0831  Lipoprotein releasing system transmembrane protein LolC [KO:K09808]
L21SP2_0833  hypothetical protein [KO:K09808]
L21SP2_0832  Lipoprotein releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
L21SP2_1807  putative membrane protein, YjgP/YjgQ family [KO:K07091]
L21SP2_1806  hypothetical protein [KO:K11720]
L21SP2_3298  Lipopolysaccharide ABC transporter, ATP-binding protein LptB [KO:K06861] [EC:7.5.2.5]
L21SP2_0751  D-alanyl-D-alanine carboxypeptidase [KO:K16905]
L21SP2_1701  ABC transport system, permease component YbhR [KO:K16905]
L21SP2_0638  ABC transporter permease protein [KO:K16905]
L21SP2_0639  ABC transporter protein [KO:K16906]
L21SP2_0750  hypothetical protein [KO:K16906]
L21SP2_1700  ABC-type multidrug transport system, permease component [KO:K16906]
L21SP2_1699  ABC transporter, ATP-binding protein [KO:K16907] [EC:7.6.2.-]
L21SP2_0641  ABC transporter, ATP-binding protein [KO:K16907] [EC:7.6.2.-]
L21SP2_0749  ABC transporter, ATP-binding protein [KO:K16907] [EC:7.6.2.-]
L21SP2_0602  ABC transporter ATP-binding protein [KO:K14698] [EC:7.-.-.-]
L21SP2_0603  Transport ATP-binding protein CydC [KO:K14699] [EC:7.-.-.-]
L21SP2_1371  ABC transporter, ATP-binding protein [KO:K18889]
L21SP2_1370  hypothetical protein [KO:K18890]
L21SP2_2051  hypothetical protein [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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