Entry Name ABC transporters - Strongylocentrotus purpuratus (purple sea urchin)
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Strongylocentrotus purpuratus (purple sea urchin) [GN:
spu ]
Gene 593710 ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
586285 ATP-binding cassette sub-family A member 3 [KO:K05643 ]
373526 ATP-binding cassette transporter subfamily A [KO:K05643 ]
588724 ATP-binding cassette sub-family A member 5 isoform X1 [KO:K05648 ]
594802 ATP-binding cassette sub-family A member 5 isoform X1 [KO:K05648 ]
754756 ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [KO:K05655 ]
575393 ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656 ]
754911 ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
583333 ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [KO:K05661 ]
577121 ATP-binding cassette sub-family B member 7, mitochondrial isoform X4 [KO:K05662 ]
591344 ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [KO:K05667 ]
591982 multidrug resistance-associated protein 4 isoform X1 [KO:K05673 ]
591276 multidrug resistance-associated protein 4 [KO:K05673 ]
755624 multidrug resistance-associated protein 4 [KO:K05673 ]
579421 multidrug resistance-associated protein 4 isoform X1 [KO:K05673 ]
752233 multidrug resistance-associated protein 4 isoform X1 [KO:K05673 ]
590330 multidrug resistance-associated protein 5 [KO:K05668 ]
578391 multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
582468 multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
593868 multidrug resistance-associated protein 5 [KO:K05668 ]
115922775 multidrug resistance-associated protein 5-like isoform X1 [KO:K05668 ]
594398 multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
584425 multidrug resistance-associated protein 5 [KO:K05668 ]
591705 multidrug resistance-associated protein 5 [KO:K05668 ]
594581 multidrug resistance-associated protein 5 [KO:K05668 ]
582918 multidrug resistance-associated protein 5 [KO:K05668 ]
582885 ABCC5a; ATP-binding cassette transporter subfamily C member 5a [KO:K05668 ]
590270 LOW QUALITY PROTEIN: multidrug resistance-associated protein 5 [KO:K05668 ]
590074 multidrug resistance-associated protein 5 [KO:K05668 ]
593157 multidrug resistance-associated protein 7 [KO:K05674 ]
577854 ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
594397 ABCC9a; ATP-binding cassette sub-family C member 9 [KO:K05033 ]
100889760 ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
100891765 ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
115918270 ATP-binding cassette sub-family C member 9-like isoform X1 [KO:K05033 ]
575256 ATP-binding cassette sub-family C member 8 [KO:K05033 ]
585445 ATP-binding cassette sub-family C member 9 [KO:K05033 ]
586814 ATP-binding cassette sub-family C member 9 [KO:K05033 ]
588997 ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
752863 ATP-binding cassette sub-family C member 8 [KO:K05033 ]
589309 LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 2 [KO:K05676 ] [EC:7.6.2.4 ]
754353 ATP-binding cassette sub-family G member 4 [KO:K05679 ]
584842 ATP-binding cassette sub-family G member 2 isoform X1 [KO:K05681 ]
578413 ATP-binding cassette sub-family G member 2 [KO:K05681 ]
578540 ATP-binding cassette, sub-family G (WHITE), member 2 [KO:K05681 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
