KEGG   PATHWAY: sroi00061
Entry
sroi00061                   Pathway                                
Name
Fatty acid biosynthesis - Streptomyces roseirectus
Class
Metabolism; Lipid metabolism
Pathway map
sroi00061  Fatty acid biosynthesis
sroi00061

Module
sroi_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:sroi00061]
Other DBs
GO: 0006633
Organism
Streptomyces roseirectus [GN:sroi]
Gene
IAG44_38025  acetyl-CoA carboxylase biotin carboxyl carrier protein subunit [KO:K02160]
IAG44_38030  acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
IAG44_41415  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
IAG44_14720  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
IAG44_28195  ACP S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
IAG44_35885  acyltransferase domain-containing protein [KO:K00645] [EC:2.3.1.39]
IAG44_37650  peptidyl-prolyl cis-trans isomerase [KO:K00645] [EC:2.3.1.39]
IAG44_20140  beta-ketoacyl-ACP synthase 3 [KO:K00648] [EC:2.3.1.180]
IAG44_28190  ketoacyl-ACP synthase III [KO:K00648] [EC:2.3.1.180]
IAG44_38410  ketoacyl-ACP synthase III [KO:K00648] [EC:2.3.1.180]
IAG44_07125  ketoacyl-ACP synthase III [KO:K00648] [EC:2.3.1.180]
IAG44_20145  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
IAG44_28180  beta-ketoacyl-[acyl-carrier-protein] synthase II [KO:K09458] [EC:2.3.1.179]
IAG44_16720  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
IAG44_31260  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_31345  fabG; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
IAG44_33850  fabG; 3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
IAG44_40285  glucose 1-dehydrogenase [KO:K00059] [EC:1.1.1.100]
IAG44_40525  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_41390  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_41400  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_01205  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_02960  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_03055  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_03515  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_09595  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_09645  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_10400  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
IAG44_11620  3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
IAG44_40835  fabV; enoyl-[acyl-carrier-protein] reductase FabV [KO:K00209] [EC:1.3.1.9 1.3.1.44]
IAG44_34985  acyl-ACP desaturase [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
IAG44_06365  acyl-ACP desaturase [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
IAG44_16710  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
IAG44_26480  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_27365  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
IAG44_29530  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_31935  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
IAG44_01195  acyl--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_02895  acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
IAG44_03020  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_42860  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_07150  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
IAG44_08240  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
IAG44_02480  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
sroi00020  Citrate cycle (TCA cycle)
sroi00071  Fatty acid degradation
sroi00410  beta-Alanine metabolism
sroi00561  Glycerolipid metabolism
sroi00564  Glycerophospholipid metabolism
sroi00620  Pyruvate metabolism
sroi00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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