Entry Name Fatty acid biosynthesis
Class Metabolism; Lipid metabolismBRITE hierarchy
Pathway map Module M00873 Fatty acid biosynthesis in mitochondria, animals [PATH:ko00061 ]
M00874 Fatty acid biosynthesis in mitochondria, fungi [PATH:ko00061 ]
Other DBs Orthology K00059 fabG, OAR1; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100 ]
K00209 fabV, ter; enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44 ]
K00645 fabD, MCAT, MCT1; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39 ]
K00647 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41 ]
K00667 FAS2; fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86 ]
K00668 FAS1; fatty acid synthase subunit beta, fungi type [EC:2.3.1.86 ]
K01071 MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21 ]
K01716 fabA; 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14 ]
K01897 ACSL, fadD; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3 ]
K02160 accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein
K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9 ]
K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59 ]
K03922 desA2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-]
K07512 MECR, NRBF1; mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38 ]
K09458 fabF, OXSM, CEM1; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179 ]
K11263 bccA, pccA, accA3; acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14 ]
K11533 fas; fatty acid synthase, bacteria type [EC:2.3.1.-]
K11539 CBR4; carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]
K13370 HSD17B8; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239 ]
K16363 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59 ]
K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14 ]
K18660 ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-]
K22540 HTD2; 3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541 HTD2; 3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
K28161 fadD13; long-chain-fatty-acid---CoA ligase
Compound C00173 Acyl-[acyl-carrier protein]
C00685 3-Oxoacyl-[acyl-carrier protein]
C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein]
C01203 Oleoyl-[acyl-carrier protein]
C01209 Malonyl-[acyl-carrier protein]
C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C03939 Acetyl-[acyl-carrier protein]
C04088 Octadecanoyl-[acyl-carrier protein]
C04246 But-2-enoyl-[acyl-carrier protein]
C04618 (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633 (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688 (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223 Dodecanoyl-[acyl-carrier protein]
C05747 (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748 trans-Hex-2-enoyl-[acp]
C05751 trans-Oct-2-enoyl-[acp]
C05754 trans-Dec-2-enoyl-[acp]
C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758 trans-Dodec-2-enoyl-[acp]
C05759 3-Oxotetradecanoyl-[acp]
C05760 trans-Tetradec-2-enoyl-[acp]
C05762 3-Oxohexadecanoyl-[acp]
C05763 trans-Hexadec-2-enoyl-[acp]
C16220 (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221 (2E)-Octadecenoyl-[acp]
C16520 Hexadecenoyl-[acyl-carrier protein]
C20683 Long-chain acyl-[acyl-carrier protein]
C20794 n-7 Unsaturated acyl-[acyl-carrier protein]
Reference Authors Salas JJ, Ohlrogge JB.
Title Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
Journal Reference Authors Zhang YM, Marrakchi H, White SW, Rock CO.
Title The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
Journal Reference Authors Voelker T, Kinney AJ.
Title VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
Journal Reference Authors Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
Title Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
Journal Reference Authors Bowman CE, Wolfgang MJ
Title Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
Journal Reference Authors Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
Title Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
Journal Reference Authors Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
Title Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
Journal Reference Authors Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
Title Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
Journal Related ko00564 Glycerophospholipid metabolism
