KEGG   PATHWAY: svl02010
Entry
svl02010                    Pathway                                
Name
ABC transporters - Streptomyces violaceusniger
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
svl02010  ABC transporters
svl02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Streptomyces violaceusniger [GN:svl]
Gene
Strvi_5905  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
Strvi_5301  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
Strvi_5063  ABC transporter substrate-binding protein [KO:K15553]
Strvi_2371  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
Strvi_0788  ABC transporter substrate-binding protein [KO:K15553]
Strvi_5903  ABC-type transporter, integral membrane subunit [KO:K15554]
Strvi_5299  ABC-type transporter, integral membrane subunit [KO:K15554]
Strvi_2369  ABC-type transporter, integral membrane subunit [KO:K15554]
Strvi_5064  ABC-type transporter, integral membrane subunit [KO:K15554]
Strvi_0787  ABC-type transporter, integral membrane subunit [KO:K15554]
Strvi_5904  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Strvi_0786  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Strvi_5300  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Strvi_2370  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Strvi_5065  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
Strvi_0381  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
Strvi_0382  molybdate ABC transporter, inner membrane subunit [KO:K02018]
Strvi_0383  ABC transporter related protein [KO:K02017] [EC:7.3.2.5]
Strvi_1985  ABC transporter, periplasmic binding protein, thiB subfamily [KO:K02064]
Strvi_1986  ABC-type transporter, integral membrane subunit [KO:K02063]
Strvi_1987  ABC transporter related protein [KO:K02062] [EC:7.6.2.15]
Strvi_2003  extracellular solute-binding protein family 1 [KO:K11069]
Strvi_4833  extracellular solute-binding protein family 1 [KO:K11069]
Strvi_2006  ABC-type transporter, integral membrane subunit [KO:K11070]
Strvi_4835  ABC-type transporter, integral membrane subunit [KO:K11070]
Strvi_2005  ABC-type transporter, integral membrane subunit [KO:K11071]
Strvi_4834  ABC-type transporter, integral membrane subunit [KO:K11071]
Strvi_2004  spermidine/putrescine ABC transporter ATPase subunit [KO:K11072] [EC:7.6.2.11]
Strvi_4836  spermidine/putrescine ABC transporter ATPase subunit [KO:K11072] [EC:7.6.2.11]
Strvi_5952  ABC-type transporter, integral membrane subunit [KO:K11081 K11083]
Strvi_8633  ABC-type glycine betaine transport, periplasmic subunit [KO:K02002]
Strvi_6631  ABC-type glycine betaine transport, periplasmic subunit [KO:K02001 K02002]
Strvi_8634  ABC-type transporter, integral membrane subunit [KO:K02001]
Strvi_6632  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
Strvi_8635  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
Strvi_8478  ABC-type glycine betaine transport, periplasmic subunit [KO:K05845]
Strvi_8890  ABC-type glycine betaine transport, periplasmic subunit [KO:K05845]
Strvi_8891  ABC-type transporter, integral membrane subunit [KO:K05846]
Strvi_8892  ABC-type transporter, integral membrane subunit [KO:K05846]
Strvi_8476  ABC-type transporter, integral membrane subunit [KO:K05846]
Strvi_8477  ABC-type transporter, integral membrane subunit [KO:K05846]
Strvi_8893  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K05847] [EC:7.6.2.9]
Strvi_8475  ABC transporter related protein [KO:K05847] [EC:7.6.2.9]
Strvi_8814  ABC transporter related protein [KO:K10112] [EC:7.5.2.-]
Strvi_7308  extracellular solute-binding protein family 1 [KO:K15770]
Strvi_7307  ABC-type transporter, integral membrane subunit [KO:K15771]
Strvi_7306  ABC-type transporter, integral membrane subunit [KO:K15772]
Strvi_8325  extracellular solute-binding protein family 1 [KO:K10117]
Strvi_3693  extracellular solute-binding protein family 1 [KO:K10117]
Strvi_8326  ABC-type transporter, integral membrane subunit [KO:K10118]
Strvi_3694  ABC-type transporter, integral membrane subunit [KO:K10118]
Strvi_8327  ABC-type transporter, integral membrane subunit [KO:K10119]
Strvi_3695  ABC-type transporter, integral membrane subunit [KO:K10119]
Strvi_3688  extracellular solute-binding protein family 1 [KO:K10227]
Strvi_3687  ABC-type transporter, integral membrane subunit [KO:K10228]
Strvi_3686  ABC-type transporter, integral membrane subunit [KO:K10229]
Strvi_1027  extracellular solute-binding protein family 1 [KO:K10232]
Strvi_8357  extracellular solute-binding protein family 1 [KO:K10232]
Strvi_8358  ABC-type transporter, integral membrane subunit [KO:K10233]
Strvi_8359  ABC-type transporter, integral membrane subunit [KO:K10234]
Strvi_2014  extracellular solute-binding protein family 1 [KO:K17318]
Strvi_3413  extracellular solute-binding protein family 1 [KO:K17318]
Strvi_2015  ABC-type transporter, integral membrane subunit [KO:K17319]
Strvi_3411  ABC-type transporter, integral membrane subunit [KO:K17319]
Strvi_2016  ABC-type transporter, integral membrane subunit [KO:K17320]
Strvi_3412  ABC-type transporter, integral membrane subunit [KO:K17320]
Strvi_2284  carbohydrate ABC transporter [KO:K10200]
Strvi_2285  ABC-type transporter, integral membrane subunit [KO:K10201]
Strvi_2286  ABC-type transporter, integral membrane subunit [KO:K10202]
Strvi_4385  extracellular solute-binding protein family 1 [KO:K10240]
Strvi_8134  extracellular solute-binding protein family 1 [KO:K10240]
Strvi_4384  ABC-type transporter, integral membrane subunit [KO:K10241]
Strvi_8135  ABC-type transporter, integral membrane subunit [KO:K10241]
Strvi_8136  ABC-type transporter, integral membrane subunit [KO:K10242]
Strvi_4383  ABC-type transporter, integral membrane subunit [KO:K10242]
Strvi_1558  extracellular solute-binding protein family 1 [KO:K17329]
Strvi_8305  extracellular solute-binding protein family 1 [KO:K17329]
Strvi_8304  ABC-type transporter, integral membrane subunit [KO:K17330]
Strvi_1559  ABC-type transporter, integral membrane subunit [KO:K17330]
Strvi_8303  ABC-type transporter, integral membrane subunit [KO:K17331]
Strvi_1560  ABC-type transporter, integral membrane subunit [KO:K17331]
Strvi_7667  extracellular solute-binding protein family 1 [KO:K17326]
Strvi_7668  ABC-type transporter, integral membrane subunit [KO:K17327]
Strvi_7669  ABC-type transporter, integral membrane subunit [KO:K17328]
Strvi_7556  sugar-binding receptor [KO:K10546]
Strvi_7558  ABC-type transporter, integral membrane subunit [KO:K10547]
Strvi_7557  ABC transporter related protein [KO:K10548] [EC:7.5.2.-]
Strvi_8564  basic membrane lipoprotein [KO:K07335]
Strvi_8562  ABC-type transporter, integral membrane subunit [KO:K23535]
Strvi_8561  ABC-type transporter, integral membrane subunit [KO:K23536]
Strvi_8563  ABC transporter related protein [KO:K23537]
Strvi_2625  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Strvi_1214  hypothetical protein [KO:K10439]
Strvi_6115  sugar ABC transporter periplasmic sugar-binding protein [KO:K10439]
Strvi_6674  hypothetical protein [KO:K10439]
Strvi_8033  ABC-type transporter, integral membrane subunit [KO:K10439 K10440]
Strvi_5563  sugar ABC transporter substrate-binding protein [KO:K10439]
Strvi_2624  ABC-type transporter, integral membrane subunit [KO:K10440]
Strvi_6112  ABC-type transporter, integral membrane subunit [KO:K10440]
Strvi_6113  ABC-type transporter, integral membrane subunit [KO:K10440]
Strvi_6111  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
Strvi_2623  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
Strvi_8032  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
Strvi_8035  D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
Strvi_2561  hypothetical protein [KO:K10543]
Strvi_2288  periplasmic binding protein/LacI transcriptional regulator [KO:K10543]
Strvi_2563  ABC-type transporter, integral membrane subunit [KO:K10544]
Strvi_2290  ABC-type transporter, integral membrane subunit [KO:K10544]
Strvi_2562  ABC transporter related protein [KO:K10545] [EC:7.5.2.10]
Strvi_2289  ABC transporter related protein [KO:K10545] [EC:7.5.2.10]
Strvi_3202  rhamnose ABC transporter, periplasmic rhamnose-binding protein [KO:K10559]
Strvi_3200  ABC-type transporter, integral membrane subunit [KO:K10560]
Strvi_3201  ABC-type transporter, integral membrane subunit [KO:K10561]
Strvi_3199  ABC transporter related protein [KO:K10562] [EC:7.5.2.-]
Strvi_0606  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
Strvi_6495  hypothetical protein [KO:K02040]
Strvi_1774  putative phosphate binding ABC transporter [KO:K02040]
Strvi_0605  phosphate ABC transporter, inner membrane subunit PstC [KO:K02037]
Strvi_0604  phosphate ABC transporter, inner membrane subunit PstA [KO:K02038]
Strvi_0603  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:7.3.2.1]
Strvi_5929  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
Strvi_5927  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
Strvi_5928  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
Strvi_2462  ABC-type transporter, periplasmic subunit family 3 [KO:K10005]
Strvi_2107  ABC-type transporter, periplasmic subunit family 3 [KO:K10005]
Strvi_2463  polar amino acid ABC transporter, inner membrane subunit [KO:K10006]
Strvi_2106  polar amino acid ABC transporter, inner membrane subunit [KO:K10006]
Strvi_2464  polar amino acid ABC transporter, inner membrane subunit [KO:K10007]
Strvi_2105  polar amino acid ABC transporter, inner membrane subunit [KO:K10007]
Strvi_2461  ABC transporter related protein [KO:K10008] [EC:7.4.2.1]
Strvi_2108  ABC transporter related protein [KO:K10008] [EC:7.4.2.1]
Strvi_7079  Extracellular ligand-binding receptor [KO:K01999]
Strvi_8694  lipoprotein [KO:K01999]
Strvi_7080  ABC-type transporter, integral membrane subunit [KO:K01997]
Strvi_7081  ABC-type transporter, integral membrane subunit [KO:K01998]
Strvi_7082  ABC transporter related protein [KO:K01995]
Strvi_7083  ABC transporter related protein [KO:K01996]
Strvi_2975  NLPA lipoprotein [KO:K02073]
Strvi_2974  ABC-type transporter, integral membrane subunit [KO:K02072]
Strvi_2973  ABC transporter related protein [KO:K02071]
Strvi_1416  ABC-type transporter, periplasmic subunit [KO:K15580]
Strvi_1429  ABC-type transporter, periplasmic subunit [KO:K15580]
Strvi_1430  ABC-type transporter, integral membrane subunit [KO:K15581]
Strvi_1417  ABC-type transporter, integral membrane subunit [KO:K15581]
Strvi_1418  ABC-type transporter, integral membrane subunit [KO:K15582]
Strvi_1431  ABC-type transporter, integral membrane subunit [KO:K15582]
Strvi_1419  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583]
Strvi_1432  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583]
Strvi_1433  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823]
Strvi_1420  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823]
Strvi_1071  ABC-type transporter, periplasmic subunit [KO:K25287]
Strvi_3733  ABC-type transporter, periplasmic subunit [KO:K25286]
Strvi_7388  ABC-type transporter, periplasmic subunit [KO:K25286]
Strvi_6871  ABC-type transporter, integral membrane subunit [KO:K23186]
Strvi_8737  ABC-type transporter, integral membrane subunit [KO:K23186]
Strvi_6870  ABC-type transporter, integral membrane subunit [KO:K23187]
Strvi_8738  ABC-type transporter, integral membrane subunit [KO:K23187]
Strvi_6869  ABC transporter related protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
Strvi_8739  ABC transporter related protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
Strvi_7784  ABC-type metal ion transporter, periplasmic subunit [KO:K09815]
Strvi_7786  ABC-type transporter, integral membrane subunit [KO:K09816]
Strvi_7785  ABC transporter related protein [KO:K09817] [EC:7.2.2.20]
Strvi_1119  cobalamin (vitamin B12) biosynthesis CbiM protein [KO:K02007]
Strvi_1120  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
Strvi_1121  cobalt ABC transporter, ATPase subunit [KO:K02006]
Strvi_7928  BioY protein [KO:K03523]
Strvi_7415  ABC-type transporter, integral membrane subunit [KO:K16785]
Strvi_2850  ABC-2 type transporter [KO:K09692]
Strvi_2851  ABC transporter related protein [KO:K09693] [EC:7.5.2.4]
Strvi_7334  ABC-2 type transporter [KO:K18233]
Strvi_3130  ABC-2 type transporter [KO:K18233]
Strvi_7333  daunorubicin resistance ABC transporter ATPase subunit [KO:K18232]
Strvi_3131  daunorubicin resistance ABC transporter ATPase subunit [KO:K18232]
Strvi_8346  protein of unknown function DUF214 [KO:K09811]
Strvi_8347  cell division ATP-binding protein FtsE [KO:K09812]
Strvi_0639  ABC transporter related protein [KO:K18887]
Strvi_0640  ABC transporter related protein [KO:K18888]
Strvi_9174  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16014]
Strvi_2134  ABC transporter related protein [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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