KEGG   PATHWAY: vko00591
Entry
vko00591                    Pathway                                
Name
Linoleic acid metabolism - Varanus komodoensis (Komodo dragon)
Class
Metabolism; Lipid metabolism
Pathway map
vko00591  Linoleic acid metabolism
vko00591

Other DBs
GO: 0043651
Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123032793  acidic phospholipase A2 HTe-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123034721  basic phospholipase A2 sphenotoxin subunit B-like [KO:K01047] [EC:3.1.1.4]
123034725  basic phospholipase A2 Cdr-13-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123034728  basic phospholipase A2 Ceg-N6-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123023193  PLA2G12A; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123018447  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
123025134  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123025419  phospholipase A2, minor isoenzyme-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123030419  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123030949  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
123027870  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123026284  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026285  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026286  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026289  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026290  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026292  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026293  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026366  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123030607  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
123030608  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
123026805  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
123026807  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123026808  cytosolic phospholipase A2 delta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123028039  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
123032561  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032562  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032563  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032564  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123035026  cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
123035029  cytochrome P450 2H2-like [KO:K07413] [EC:1.14.14.1]
123018898  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123019432  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123019440  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123019512  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025295  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025296  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025297  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025298  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025301  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123025019  cytochrome P450 3A24-like isoform X1 [KO:K07424] [EC:1.14.14.1]
123025020  cytochrome P450 3A9-like [KO:K07424] [EC:1.14.14.1]
123025117  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
vko00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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