KEGG   PATHWAY: ko00591
Entry
ko00591                     Pathway                                
Name
Linoleic acid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
ko00591  Linoleic acid metabolism
ko00591

Other DBs
GO: 0043651
Orthology
K00454  LOX2S; lipoxygenase [EC:1.13.11.12]
K00460  ALOX15; arachidonate 15-lipoxygenase [EC:1.13.11.33]
K00508  E1.14.19.3; linoleoyl-CoA desaturase [EC:1.14.19.3]
K01047  PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]
K01058  pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
K07409  CYP1A2; cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07413  CYP2C; cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07415  CYP2E1; cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K07418  CYP2J; cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
K07424  CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K08262  E1.14.19.39; acyl-lipid delta12-acetylenase [EC:1.14.19.39]
K14621  PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]
K14674  TGL4; TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
K15718  LOX1_5; linoleate 9S-lipoxygenase [EC:1.13.11.58]
K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
K16817  PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
K17689  CYP3A4; cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17718  CYP2C8; cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  CYP2C9; cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17721  CYP2C19; cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
K17862  PPOC; linoleate 10R-lipoxygenase [EC:1.13.11.62]
K17863  PPOA; linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase [EC:1.13.11.60 5.4.4.5]
K17864  LDS; linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase [EC:1.13.11.60 5.4.4.6]
K21794  E1.13.11.45; linoleate 11-lipoxygenase [EC:1.13.11.45]
K27599  DES; etheroleic acid synthase
K27600  CYP74M3; etheroleic acid synthase
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
ko00590  Arachidonic acid metabolism

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