KEGG   PATHWAY: xcz03070
Entry
xcz03070                    Pathway                                
Name
Bacterial secretion system - Xanthomonas cucurbitae
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
xcz03070  Bacterial secretion system
xcz03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Xanthomonas cucurbitae [GN:xcz]
Gene
EBN15_15490  hypothetical protein [KO:K12340]
EBN15_15655  HlyD family type I secretion periplasmic adaptor subunit [KO:K11003]
EBN15_15660  type I secretion system permease/ATPase [KO:K11004]
EBN15_16890  EscC/YscC/HrcC family type III secretion system outer membrane ring protein [KO:K03219]
EBN15_16920  EscJ/YscJ/HrcJ family type III secretion inner membrane ring protein [KO:K03222]
EBN15_16955  EscR/YscR/HrcR family type III secretion system export apparatus protein [KO:K03226]
EBN15_16960  EscS/YscS/HrcS family type III secretion system export apparatus protein [KO:K03227]
EBN15_16895  EscT/YscT/HrcT family type III secretion system export apparatus protein [KO:K03228]
EBN15_16935  EscU/YscU/HrcU family type III secretion system export apparatus switch protein [KO:K03229]
EBN15_16940  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
EBN15_16905  EscN/YscN/HrcN family type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
EBN15_16950  YscQ/HrcQ family type III secretion apparatus protein [KO:K03225]
EBN15_16910  HrpE/YscL family type III secretion apparatus protein [KO:K03223]
EBN15_15925  gspD; type II secretion system protein GspD [KO:K02453]
EBN15_02685  gspD; type II secretion system protein GspD [KO:K02453]
EBN15_15930  PDZ domain-containing protein [KO:K02452]
EBN15_15915  gspF; type II secretion system protein GspF [KO:K02455]
EBN15_02640  type II secretion system F family protein [KO:K02455]
EBN15_15910  gspG; type II secretion system protein GspG [KO:K02456]
EBN15_02645  gspG; type II secretion system protein GspG [KO:K02456]
EBN15_15905  gspH; type II secretion system protein GspH [KO:K02457]
EBN15_02650  type II secretion system protein GspH [KO:K02457]
EBN15_15900  gspI; type II secretion system protein GspI [KO:K02458]
EBN15_02655  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02458]
EBN15_15895  gspJ; type II secretion system protein GspJ [KO:K02459]
EBN15_02660  type II secretion system protein J [KO:K02459]
EBN15_15890  general secretion pathway protein GspK [KO:K02460]
EBN15_02665  general secretion pathway protein GspK [KO:K02460]
EBN15_15885  type II secretion system protein GspL [KO:K02461]
EBN15_02670  general secretion pathway protein GspL [KO:K02461]
EBN15_15880  type II secretion system protein M [KO:K02462]
EBN15_02675  general secretion pathway protein GspM [KO:K02462]
EBN15_15920  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
EBN15_19525  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
EBN15_02635  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
EBN15_09770  secD; protein translocase subunit SecD [KO:K03072]
EBN15_09775  secF; protein translocase subunit SecF [KO:K03074]
EBN15_03715  secE; preprotein translocase subunit SecE [KO:K03073]
EBN15_08610  secG; preprotein translocase subunit SecG [KO:K03075]
EBN15_03880  secY; preprotein translocase subunit SecY [KO:K03076]
EBN15_09765  yajC; preprotein translocase subunit YajC [KO:K03210]
EBN15_20005  yidC; membrane protein insertase YidC [KO:K03217]
EBN15_03020  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
EBN15_09560  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
EBN15_19150  secB; protein-export chaperone SecB [KO:K03071]
EBN15_05280  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
EBN15_19555  twin-arginine translocase subunit TatA [KO:K03116]
EBN15_19550  tatB; twin-arginine translocase subunit TatB [KO:K03117]
EBN15_19545  tatC; twin-arginine translocase subunit TatC [KO:K03118]
EBN15_09135  lytic transglycosylase domain-containing protein [KO:K03194]
EBN15_09140  hypothetical protein [KO:K03197]
EBN15_09145  hypothetical protein [KO:K03198]
EBN15_09155  hypothetical protein [KO:K03200]
EBN15_09190  hypothetical protein [KO:K03200]
EBN15_09220  hypothetical protein [KO:K03200]
EBN15_09255  hypothetical protein [KO:K03200]
EBN15_09285  hypothetical protein [KO:K03200]
EBN15_09120  type IV secretion system protein VirB9 [KO:K03204]
EBN15_09160  type IV secretion system protein [KO:K03201]
EBN15_09195  type IV secretion system protein [KO:K03201]
EBN15_09225  type IV secretion system protein [KO:K03201]
EBN15_09260  type IV secretion system protein [KO:K03201]
EBN15_09290  type IV secretion system protein [KO:K03201]
EBN15_12245  type IV secretion system protein [KO:K03201]
EBN15_12305  type IV secretion system protein [KO:K03201]
EBN15_09115  type IV secretion system protein [KO:K03203]
EBN15_09125  TrbI/VirB10 family protein [KO:K03195]
EBN15_09150  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
EBN15_09130  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
EBN15_08300  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
EBN15_08315  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
EBN15_15290  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
EBN15_01130  tssI; type VI secretion system tip protein VgrG [KO:K11904]
EBN15_00805  Hcp1 family type VI secretion system effector [KO:K11903]
EBN15_01155  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
EBN15_01150  type VI secretion system protein TssL [KO:K11892]
EBN15_00830  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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