KEGG   PATHWAY: yma03070
Entry
yma03070                    Pathway                                
Name
Bacterial secretion system - Yersinia massiliensis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
yma03070  Bacterial secretion system
yma03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Yersinia massiliensis [GN:yma]
Gene
DA391_02810  outer membrane channel protein TolC [KO:K12340]
DA391_20870  type III secretion apparatus needle protein [KO:K03221]
DA391_21155  EscF/YscF/HrpA family type III secretion system needle major subunit [KO:K03221]
DA391_21215  EscC/YscC/HrcC family type III secretion system outer membrane ring protein [KO:K03219]
DA391_21140  EscJ/YscJ/HrcJ family type III secretion inner membrane ring protein SsaJ [KO:K03222]
DA391_21090  EscR/YscR/HrcR family type III secretion system export apparatus protein [KO:K03226]
DA391_21085  EscS/YscS/HrcS family type III secretion system export apparatus protein [KO:K03227]
DA391_21080  EscT/YscT/HrcT family type III secretion system export apparatus protein [KO:K03228]
DA391_21075  EscU/YscU/HrcU family type III secretion system export apparatus switch protein [KO:K03229]
DA391_20845  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
DA391_21115  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
DA391_21110  EscN/YscN/HrcN family type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
DA391_20820  type III secretion protein [KO:K03225]
DA391_21095  YscQ/HrcQ family type III secretion apparatus protein [KO:K03225]
DA391_20955  gspD; type II secretion system protein GspD [KO:K02453]
DA391_21010  secretion protein [KO:K02465]
DA391_20950  general secretion pathway protein GspC [KO:K02452]
DA391_20965  gspF; type II secretion system protein GspF [KO:K02455]
DA391_20970  gspG; type II secretion system protein GspG [KO:K02456]
DA391_20975  gspH; type II secretion system protein GspH [KO:K02457]
DA391_20980  gspI; type II secretion system protein GspI [KO:K02458]
DA391_20985  gspJ; type II secretion system protein GspJ [KO:K02459]
DA391_20990  general secretion pathway protein GspK [KO:K02460]
DA391_20995  type II secretion system protein GspL [KO:K02461]
DA391_21000  general secretion pathway protein GspM [KO:K02462]
DA391_20960  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
DA391_23580  hypothetical protein [KO:K02464] [EC:3.4.23.43 2.1.1.-]
DA391_21005  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
DA391_04555  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
DA391_17070  secD; protein translocase subunit SecD [KO:K03072]
DA391_17065  protein translocase subunit SecF [KO:K03074]
DA391_21410  preprotein translocase subunit SecE [KO:K03073]
DA391_19850  preprotein translocase subunit SecG [KO:K03075]
DA391_01330  preprotein translocase subunit SecY [KO:K03076]
DA391_17075  preprotein translocase subunit YajC [KO:K03210]
DA391_23130  membrane protein insertase YidC [KO:K03217]
DA391_18610  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
DA391_18615  secA regulator SecM [KO:K13301]
DA391_21725  signal recognition particle-docking protein FtsY [KO:K03110]
DA391_22455  protein-export protein SecB [KO:K03071]
DA391_17545  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
DA391_21550  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
DA391_21545  twin-arginine translocase subunit TatB [KO:K03117]
DA391_21540  tatC; twin-arginine translocase subunit TatC [KO:K03118]
DA391_16290  twin-arginine translocase subunit TatA [KO:K03425]
DA391_24110  conjugal transfer protein TraG [KO:K03205] [EC:7.4.2.8]
DA391_03465  type VI secretion system tip protein VgrG [KO:K11904]
DA391_03445  type VI secretion system tube protein Hcp [KO:K11903]
DA391_23185  type VI secretion system tube protein Hcp [KO:K11903]
DA391_23835  type VI secretion system tube protein Hcp [KO:K11903]
DA391_03510  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DA391_03490  type VI secretion protein VasK [KO:K11891]
DA391_03435  DotU family type IV/VI secretion system protein [KO:K11892]
DA391_03450  clpV; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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