Plasmodium brasilianum: 92369569
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Entry
92369569 CDS
T10352
Symbol
MKS88_001481
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
KO
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
Organism
pbrs Plasmodium brasilianum
Pathway
pbrs00240
Pyrimidine metabolism
pbrs00670
One carbon pool by folate
pbrs00790
Folate biosynthesis
pbrs01100
Metabolic pathways
pbrs01232
Nucleotide metabolism
pbrs01240
Biosynthesis of cofactors
Module
pbrs_M00841
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
pbrs_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:
pbrs00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
92369569 (MKS88_001481)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
92369569 (MKS88_001481)
00670 One carbon pool by folate
92369569 (MKS88_001481)
Enzymes [BR:
pbrs01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
92369569 (MKS88_001481)
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
92369569 (MKS88_001481)
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Paralog
GFIT
Motif
Pfam:
Thymidylat_synt
DHFR_1
Motif
Other DBs
NCBI-GeneID:
92369569
NCBI-ProteinID:
XP_067074847
UniProt:
A0ACB9YDE3
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Position
5:<1002318..>1004183
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AA seq
621 aa
AA seq
DB search
MEDLADIFDIYAICACCKVPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSV
TTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPK
QYKPLPNRINVVLSRTLKKEDVKEDIFIINNMDQLVLLLKKLNYYKCFIIGGAIVYKECL
ERNLIKQIYFTRINNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALT
QESLPHQSSGSDKGSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDE
EDDLVYFNFNNNKNEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTG
VGVLSKFGYIMKFNLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEAN
GTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDP
TSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSI
FTHMIAQVCNLQPAQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFT
ISDFTIQNYVHHDKISMDMAA
NT seq
1866 nt
NT seq
+upstream
nt +downstream
nt
atggaagacctggctgatattttcgacatatatgccatctgcgcttgctgtaaagtgcca
aatcagggtgaaggtaaaaaaaatgaaatatttagcaccaaaacgtttagaggccttggc
aataaaggatgtctaccatggaaaagtaattcgttagatatgaaatatttcagctcagta
actacatatgttaatgaaatgaaatataaaaaattaaaatataaaagagagaaatattta
gaaaaggaaatatcaaatgaaaacagtagtacagtttttgaaaatatatcactactgtca
tcaagtaaattacaaaatgttgtagtgatggggagaagtagctgggttagtattccaaag
cagtataagcctttgccgaacagaataaatgtagtactatcaagaacacttaaaaaagaa
gatgttaaagaagatatttttataataaataatatggatcaactagttttacttttaaaa
aaattaaattattacaaatgctttattattggtggggcaatagtttacaaggagtgttta
gaaagaaatttaataaaacaaatttattttacgagaataaataatgtctacgaatgtgat
gttttctttccagaaattgatgaaaatgtgtttcaaattacgtctgtgagtgatgtgtat
actagcaactgcacgtcgttagactttgtaattttcagtaaacgcaagaaggcattgacc
caagaatccctcccccatcagagtagtggaagcgacaaaggcagtaacaccagcagtact
atcagcaatggtgctatgagcagtaatactatcaggggtagtactacaagcagcagtggt
aaagggaaaggaggaggcgaatctatttttgagcgggaatataacttcatgggagacgaa
gaagacgatttagtatatttcaactttaataataacaaaaatgaatataaaaatgcagaa
aatgccaatgactttaaaatatacaacagtttaaaatttaaacatcacccagaatatcaa
tatttaagtattatatatgatatcattatgaatggaaataaacaaaatgacagaacaggt
gtaggagtactaagtaaatttgggtatattatgaaatttaatttaaatcaatattttcca
ttattaacaacaaagaaattattccttagaggaataattgaagagttactttggtttata
agaggagaaacaaatggaaatactttgttaaataaaaatgtaagaatatgggaagcaaat
ggaacaagagaatttttggataacagaaaattattccatagagaagttaatgacttagga
cctatatatggttttcaatggaggcatttcggtgctgaatatacaaatatgcatgccaac
tatgaagataaaggagttgatcaattaaaaaatattatccatttaataaaaaatgatcca
actagtagaagaattattttgtgtgcatggaatgttaaagatcttgatcaaatggcacta
cctccttgtcatattttatgccaattttatgtttttgatggaaaattatcatgtattatg
tatcaaaggtcatgtgatttaggtttaggagtcccttttaatattgcctcctattcaata
ttcactcatatgattgcacaagtgtgtaatttacagcctgcacagttcatacatatttta
ggaaatgcacatgtttataataatcatattgacagcttaaaagtacagttaaataggata
ccctaccccttcccaactcttaaattaaatcctgaaataaagaacattgaagactttaca
atatcggattttacaatccaaaattacgtgcaccatgataaaatttctatggacatggcc
gcgtga
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