KEGG   Physeter macrocephalus (sperm whale): 102985160
Entry
102985160         CDS       T06011                                 
Name
(RefSeq) steroid 21-hydroxylase
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00140  Steroid hormone biosynthesis
pcad01100  Metabolic pathways
pcad04925  Aldosterone synthesis and secretion
pcad04927  Cortisol synthesis and secretion
pcad04934  Cushing syndrome
Module
pcad_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    102985160
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    102985160
   04927 Cortisol synthesis and secretion
    102985160
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102985160
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:pcad00199]
    102985160
Enzymes [BR:pcad01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     102985160
Cytochrome P450 [BR:pcad00199]
 Cytochrome P450, animal type
  CYP21 family
   102985160
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 102985160
NCBI-ProteinID: XP_023977630
Ensembl: ENSPCTG00005006933
UniProt: A0A2Y9SMR0
LinkDB
Position
18:complement(84818109..84820749)
AA seq 492 aa
MVLVGLLLLPLLVGTCLLWGRWKLRSLRLPPLVPGFLHLLRPNLPIYLLSLTQKLGPIYR
LRLGLQDVVVLNSKRTIEEALIRKWVDFAGRPQIPSYQLVCQHCQDISLGDYSVLWKAHK
KLTRSALLLGVRSSMEPRVQQLTQEFCERMKAQAGAPVTIQKEFSLLTCSIICYLTFGDK
EDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAMENRDHIVEKQLR
QHKESMVAGQWRDTTDYMLQGLGKQRVEEGPGQLLEGHVHMSVVDLFIGGTETTANTLSW
AVAFLLHHPEIQRRLQEELDRELGPGASGSRIPYKDRARLPLLNATIAEVLRLRPVVPLA
LPHRATRASSIFGYDIPEGTVVIPNLQGAHLDETVWERPHEFRPDRFLDPGANPSALAFG
CGARVCLGEPLARLELFVVLGQLLQAFTLLSPAGALPSLQPHPYCGVNLKIQPFQVRLQP
RGRGGRGVAERQ
NT seq 1479 nt   +upstreamnt  +downstreamnt
atggtactcgtagggctgctgctgctgcccctgctagtcggcacttgcctgctgtggggc
cggtggaagctcaggagcctccgcctcccacctcttgtccccggcttcctgcacctgctg
cggcccaacctccccatctatctgcttagcctgactcagaaactcgggcccatctaccgg
ctccgcctcgggctgcaagatgtggtggtgctgaactccaagaggaccattgaggaggcc
ctgatcaggaagtgggtggactttgccggcagaccccagataccgtcctaccagctggtg
tgtcagcactgccaggacatctcactaggggactactccgtgctctggaaggcccacaag
aaactcacgcgctcagccctgctgctgggcgtccgcagctccatggagccccgggtgcag
cagctgacccaggagttctgtgagcgcatgaaagcccaggctggcgcccccgtgaccatc
cagaaggaattctctctcctcacctgcagcatcatctgttacctcacctttggagacaag
gaggacaccttagtacatgcctttcacgactgtgtccaggacttgatgaaaacctgggac
cactggtccatccaaattttggacatggttccctttctcaggttcttccccaaccccggg
ctctggaggctgaagcaggccatggagaacagggaccacattgtagagaagcagctgagg
cagcacaaggagagcatggtggccggccaatggagggacacgactgactacatgctccag
ggcctggggaagcaaagagtggaagagggccccgggcagctcctcgaagggcacgtgcat
atgtccgtggtggaccttttcatcggtggcactgagaccacggcaaacaccctttcctgg
gctgtggcgttcctgcttcaccaccctgagattcagcggcgactgcaggaggagttggat
cgcgagctgggccccggggcctcgggctcccgaatcccatacaaggaccgcgctcggctg
cccttgctcaacgccaccatcgctgaggtgctgcgcctgcggcccgtcgtgcccctggcc
ttgccgcaccgcgccacgcgggctagcagcatcttcggctacgacatccccgagggcacg
gttgtcatccccaacctccaaggtgcccacctggacgagactgtgtgggagcggccgcac
gagttccggccggaccgcttcctggatccgggcgcgaaccccagcgcgctggcctttggc
tgcggggcgcgcgtgtgcctgggcgagccgctggcgcgcctcgagctcttcgtggtgctg
gggcaactgctgcaggccttcacgctgctgtcgcccgcgggcgccctgccctcgctgcag
ccccatccctactgcggcgtcaacctcaagattcagcctttccaggtgcggctgcagccc
cgggggcgcggagggcggggcgtggccgagcgccaatga

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