Phascolarctos cinereus (koala): 110197189
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Entry
110197189 CDS
T05867
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
pcw
Phascolarctos cinereus (koala)
Pathway
pcw00350
Tyrosine metabolism
pcw00790
Folate biosynthesis
pcw01100
Metabolic pathways
pcw04728
Dopaminergic synapse
pcw04917
Prolactin signaling pathway
pcw05012
Parkinson disease
pcw05030
Cocaine addiction
pcw05031
Amphetamine addiction
pcw05034
Alcoholism
Module
pcw_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
pcw00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
110197189 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
110197189 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
110197189 (TH)
09156 Nervous system
04728 Dopaminergic synapse
110197189 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
110197189 (TH)
09165 Substance dependence
05030 Cocaine addiction
110197189 (TH)
05031 Amphetamine addiction
110197189 (TH)
05034 Alcoholism
110197189 (TH)
Enzymes [BR:
pcw01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
110197189 (TH)
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Ortholog
Paralog
GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
110197189
NCBI-ProteinID:
XP_020826537
UniProt:
A0A6P5IWL1
LinkDB
All DBs
Position
Unknown
AA seq
494 aa
AA seq
DB search
MPTPNISTPPAKGFRRAVSELDSKQAEAIMSPRFIGRRQSLIEDARKEREAAMAAAAAEA
SGDPLDAIVFEEKDGKALLNLFFTLKTAKSTSLSRALKVFETFEAKIHHLETRTNRKPKE
GTSELEYFVRCEVHSSDLGAFLSSVRRVSDEVRSTKEHKIHWFPRKISELDKCHHLVTKF
DPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPRVEYTAEEIATWREVFTTLKSLY
PTHACREHVEAFQLLERSCGYSENNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLSSL
AFRVFQCTQYVRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGATDEEI
EKLSTLYWFTVEFGLCKQNGAVKAYGAGLLSSYGELIHSLSEEPEVREFDPEAAAVQPYQ
DQTYQPVYFVSESFSDAKDKLRNYSTQICRPFSVKFDPYTLGIEVLDSPQKIQRSLQGVQ
DELHLLTHALNAMS
NT seq
1485 nt
NT seq
+upstream
nt +downstream
nt
atgcccactccaaacatctccacgcctccggccaagggcttccgcagggcagtgtccgag
ctggattccaaacaggcggaggccattatgtccccgaggttcattggcaggcggcagagc
ctcattgaagatgctcgcaaggaaagggaggcagccatggcagctgcggcagcggaggcc
tccggggatcccctagacgccattgtctttgaggagaaggatggaaaggccctcctcaac
ctcttcttcactctgaagacagccaagtccacatcactgtcccgggccctgaaagtgttc
gagacgttcgaagccaaaatccaccacctggagaccagaaccaacaggaagccgaaggag
gggacgtcggagctcgaatactttgtccgctgtgaagtccacagcagcgacctgggcgcc
ttcctcagctccgtccggagggtctccgacgaggtgcgcagcaccaaggagcacaaaatt
cactggtttcccagaaagatctccgaactggacaaatgccaccacctggtcaccaaattt
gaccctgatctggacctggaccacccaggattttctgatcaggtctatcgccagcggagg
aagctgatagcagaaatcgctttccaatacaagcatggagagccgatcccccgcgtggag
tatacagcagaggagatcgccacctggagagaggtcttcaccaccctgaagagcctgtac
cctacccatgcttgccgggagcatgtggaggccttccagctgctggaaaggtcctgcggc
tacagcgagaataacatcccccagcttgaagatgtgtcccgctttctgaaggagaggaca
ggcttccagctgaggccagtggccggcctgctctctgcccgagacttcctgtccagcctg
gctttcagggtgttccagtgcacccaatatgtccgccatgcctcctcgcccatgcattcc
ccagagccggactgctgtcatgagctcctggggcacgtgcccatgctggcagacaggact
tttgcccagttctcccaggatattggccttgcctccctcggtgccaccgatgaggagatt
gagaagttatccacgctctactggttcaccgtggagtttgggctctgcaagcagaacgga
gctgtcaaagcctatggagccggcctcctgtcctcctatggggagctcatccactccctg
tccgaggagcccgaggtccgggagtttgaccccgaggccgccgctgtgcagccgtaccag
gaccaaacctaccagcctgtctacttcgtgtcggagagctttagtgatgccaaagacaag
ctcaggaactactcgactcaaatctgccgccccttctctgtgaagtttgacccctacaca
ctgggcatagaggtcctggacagcccccagaagatccagcgctctctgcaaggcgtccag
gatgagcttcacttgttgacccatgcgctcaatgccatgagctaa
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